<< The most aggressive form of pancreatic cancer -- often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." >>
<< Our findings are the first to show that cancer cell death via necroptosis [programmed necrosis] can actually promote tumor growth, as this process results in suppression of the body's immune response against the cancer, (..) what is equally significant is that these findings might also be relevant to other tumor types. >>
<< This study exemplifies the importance of examining cancer within the actual context in which it grows (..) In our initial studies, inhibiting necroptosis in PDAC [pancreatic ductal adenocarcinoma] cells increased their ability to grow in tissue culture. However, when we began to study the same process in mice, we were surprised to see just the opposite effect, and this was mainly due to the immune response of the cells surrounding the tumor. >>
NYU LANGONE MEDICAL CENTER / NEW YORK UNIVERSITY SCHOOL OF MEDICINE. Cell death mechanism may - paradoxically - enable aggressive pancreatic cells to live on. 22-Apr-2016
Lena Seifert , Gregor Werba, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature 532, 245–249 (14 April 2016) doi:10.1038/nature17403.