sabato 13 agosto 2016

# s-brain: growing mini human brains (3D midbrain-like organoids) ...

AA << developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers of neuronal cells expressing characteristic markers of human midbrain. >>

AA << detected electrically active and functionally mature mDA (midbrain dopaminergic) neurons and dopamine production in 3D midbrain-like organoids (MLOs). In contrast to human mDA neurons generated using 2D methods or MLOs generated from mouse embryonic stem cells, (AA) human MLOs produced neuromelanin-like granules that were structurally similar to those isolated from human substantia nigra tissues. >>

AA <<  MLOs bearing features of the human midbrain may provide a tractable in vitro system to study the human midbrain and its related diseases. >>

Junghyun Jo, Yixin Xiao, et al. Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell Stem Cell. Volume 19, Issue 2, p248–257, 4 August 2016. DOI:


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