mercoledì 26 luglio 2017

# s-pnei: brain-like activities; syntesis and release of dopamine by T-cells

<< a proportion of human TFH  [follicular helper T] cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine.  TFH cells produce high amounts of dopamine and release it upon cognate interaction with B cells >>

<< faster dopamine-induced T–B-cell interactions increase total germinal centre output and accelerate it by days >>

Ilenia Papa, David Saliba, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature 547, 318–323 (July 20, 2017) doi: 10.1038/nature23013

Kate Prestt. Discovery of brain-like activity in immune system promises better disease treatments. July 13, 2017

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