giovedì 7 giugno 2018

# drugs: the sweet side of a snake venom (B. jararaca)

AA << report on the sweet side of snake venom toxins >>

<< most proteins in lancehead venom are modified with glycans, which can affect the proteins' folding, stability and binding >>

<< Glycans containing sialic acid may help in venom solubility and increase toxin half-life >>

<< Sialic acid on a toxic enzyme may also bind to host proteins called siglecs [sialic acid-binding Ig superfamily  lectins], pulling the enzyme closer to target cells for greater effect >>

How just drops of viper venom pack a deadly punch. Am Soc for Biochem and Molec Biol. Jun 1, 2018.

Debora Andrade-Silva, David Ashline, et al. Structures of N-Glycans of Bothrops venoms revealed as molecular signatures that contribute to venom phenotype in viperid snakes. Molecular & Cellular Proteomics. doi: 10.1074/mcp.RA118.000748 mcp.RA118.000748. May 1, 2018.

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