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venerdì 24 novembre 2017

# gst-chem: cascade reactions to generate complexity by triggering new chemical bonds from simple parent substances

<< organic chemists can synthesize substances of almost any complexity — vitamins, proteins, terpenes, etc. To do this, they often use cascade reactions, sequences of several chemical transformations in the course of which new chemical bonds are formed >>

<< cascade reactions are a powerful tool for rapidly increasing molecular complexity, that is, for obtaining complex compounds from simple parent substances >>

AA << have developed a new chemical reaction to synthesize a whole class of yet unexplored substances – diazabicyclo [3.2.1] octanes. These compounds are used in drug development >>

Scientists report a new cascade reaction. Nov 15, 2017

https://m.phys.org/news/2017-11-scientists-cascade-reaction.html

Dmitry V. Osipov, Irina V. Melnikova, et al. Synthesis of 8-substituted 1,5-diazabicyclo[3.2.1]octane derivatives via double aza-Michael addition of homopiperazine to 3-trifluoroacetyl-4H-chromenes.  Journal of Fluorine Chemistry. 2017; 202: 71-5.  doi: 10.1016/ j.jfluchem.2017.09.006  Sep 14, 2017.

http://www.sciencedirect.com/science/article/pii/S0022113917303676

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