# s-brain: sirt3: running-wheel against degeneration ...

<< Running wheel exercise increases the expression of Sirt3 in hippocampal neurons, which is mediated by excitatory glutamatergic neurotransmission and is essential for mitochondrial protein acetylation homeostasis and the neuroprotective effects of running. >>

<<  SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration. >>

Aiwu Cheng, Ying Yang,  et al. Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges. Cell Metabolism. In Press. DOI: http://dx.doi.org/10.1016/j.cmet.2015.10.013

http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00529-X