# age: autophagy inactivation (e.g. in neurons) to reverse the effects of age (50% extension of life) in the whole old body (post-reproductive C. elegans)

AA << identified that the inactivation of genes governing the early stages of autophagy up until the stage of vesicle nucleation, such as bec-1, strongly extend both life span and health span >>

AA << demonstrate that the improvements in health and longevity are mediated through the neurons, resulting in reduced neurodegeneration and sarcopenia >>

AA << propose that autophagy switches from advantageous to harmful in the context of an age-associated dysfunction >>

Thomas Wilhelm, Jonathan Byrne, et al.  Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans. Genes & Dev. Sep 7, 2017 doi: 10.1101/gad.301648

http://m.genesdev.cshlp.org/content/31/15/1561

<< By inactivating autophagy in the neurons of old worms they were not only able to prolong the worms life but they increased the total health of the worms dramatically >>

Why we did not evolve to live forever: Unveiling the mystery of  why we age.  Breakthrough in  understanding the origin of the  ageing process. Sep 07,  2017

http://www.uni-mainz.de/presse/aktuell/2595_ENG_HTML.php

Why we did not evolve to live forever: Unveiling the mystery of why we age. Sep 15, 2017.

https://www.sciencedaily.com/releases/2017/09/170915144151.htm