# game: low-cooperativity feedbacks in burst size could be preferable for noisy proteins

AA << consider a specific kind of negative feedback, which makes bursts smaller in the excess of protein >>

<< Increasing the strength of the feedback may lead to dramatically different outcomes depending on a key parameter, the noise load >>

<< for noise loads smaller than critical, the coefficient of variation remains bounded with increasing feedback strength; contrastingly, if the noise load is larger than critical, the coefficient of variation diverges to infinity in the limit of ever greater feedback strengths >>

<< Interestingly, high-cooperativity feedbacks have lower critical noise loads, implying that low-cooperativity feedbacks in burst size can be preferable for noisy proteins >>

Pavol Bokes, Abhyudai Singh, Yen Ting Lin. High Cooperativity In Negative Feedback Can Amplify Noisy Gene Expression. biorxiv sysbio. doi: 10.1101/125914  April 10, 2017.

http://www.biorxiv.org/content/early/2017/04/10/125914