# chem: to explore the structure of small molecules

<< In the many scientific endeavors that  are driven by organic chemistry, unambiguous identification of small molecules is of paramount importance (..) the  unambiguous determination of a small molecule’s structure  requires  X-ray  and/or neutron  diffraction  studies.  In practice, however,  X-ray crystallography is rarely applied in routine organic chemistry due to  intrinsic limitations  of both  the analytes and the technique. >>

AA << report the use of the CryoEM (cryo-electron microscopy) method MicroED (micro-electron diffraction) to provide routine and unambiguous structural determination of small organic molecules. >>

Christopher G. Jones, Michael W. Martynowycz, et al. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination. ChemRxiv Oct 17, 2018 doi: 10.26434/chemrxiv.7215332.v1

https://chemrxiv.org/articles/The_CryoEM_Method_MicroED_as_a_Powerful_Tool_for_Small_Molecule_Structure_Determination/7215332

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