# game: cooperation and trust; cooperative behaviors (mediated by MDMA) without gullibility

<< Social decision-making is fundamental for successful functioning, and can be affected in psychiatric illness and by serotoninergic modulation. The Prisoner's Dilemma (PD) is the archetypal paradigm to model cooperation and trust. However, the effect of serotonergic enhancement is poorly characterised, and its influence on the effect of variations in opponent behaviour unknown. >>

<< MDMA [3,4-Methyl​ene dioxy​ methamphetamine ] increased cooperative behaviour when playing trustworthy opponents. Underlying this was a change in brain activity of regions linked to social cognition. [AA]  findings highlight the context-specific nature of MDMA's effect on social decision-making. >>

Anthony S Gabay, Matthew J Kempton, et al. MDMA increases cooperation and recruitment of social brain areas when playing trustworthy players in an iterated Prisoner's Dilemma. Journal of Neuroscience.  Nov 19,  2018, 1276-18. doi: 10.1523/JNEUROSCI.1276-18.2018.

http://www.jneurosci.org/content/early/2018/11/16/JNEUROSCI.1276-18.2018

MDMA makes people cooperative, but not gullible.  King's College London. Nov 19, 2018.

https://m.medicalxpress.com/news/2018-11-mdma-people-cooperative-gullible.html

MDMA  [3,4-Methyl​ene dioxy​ methamphetamine ]

https://en.m.wikipedia.org/wiki/MDMA