# physio: bioclocks: liver knows what time it is.

Two studies << analyze the network of internal clocks that regulate metabolism. Although researchers had suspected that the body's various circadian clocks could operate independently from the central clock in the hypothalamus of the brain, there was previously no way to test the theory >>

<< The results were quite surprising, (..) No one realized that the liver or skin could be so directly affected by light.>> Paolo Sassone-Corsi.

Body parts respond to day and night independently from brain, studies show.  University of California, Irvine.  May 30, 2019

https://m.medicalxpress.com/news/2019-05-body-day-night-independently-brain.html    

Patrick-Simon Welz, Valentina M. Zinna, et al.  BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis. Cell. Volume 177, Issue 6, P1436-1447.E12. doi: 10.1016/ j.cell.2019.05.009.  May 30, 2019.

https://www.cell.com/cell/fulltext/S0092-8674(19)30507-0

Also

"BMAL1"

https://www.ncbi.nlm.nih.gov/pmc/?term=bmal1