# biophys: to sense 'fever' in tiny bio-entities (worms C. elegans)

<< a reliable, precise, microscope-based thermometer using quantum technology (..) measures the temperature for microscopic animals. The technology detects temperature-dependent properties of quantum spins in fluorescent nanodiamonds. >>

<< Quantum sensing is a technology that exploits the ultimate sensitivity of fragile quantum systems to the surrounding environment. High-contrast MRIs (Magnetic Resonance Imaging) are examples of quantum spins in fluorescent diamonds and are some of the most advanced quantum systems working at the forefront of real-world applications. Applications of this technique to thermal biology were introduced seven years ago to quantify temperatures inside cultured cells. However, they had yet to be applied to dynamic biological systems where heat and temperature are more actively involved in biological processes. >>

Get diamonds, take temperature: Quantum thermometer using nanodiamonds senses a 'fever' in tiny worms C. elegans. Osaka City University. Sep 11, 2020. 

https://phys.org/news/2020-09-diamonds-temperature-quantum-thermometer-nanodiamonds.html  

The technique << demonstrates the submicrometer localization of temperature information in living animals and direct identification of their pharmacological thermogenesis, which may allow for quantification of their biological activities based on temperature. >>

Masazumi Fujiwara, Simo Sun, et al. Real-time nanodiamond thermometry probing in vivo thermogenic responses. Science Advances. Vol. 6, no. 37, eaba9636. doi: 10.1126/ sciadv.aba9636. Sep 11, 2020.

https://advances.sciencemag.org/content/6/37/eaba9636