# gst: stitch together at both ends to selective formation of classes of bicyclic medium-sized ring compounds

AA << have discovered catalyst-controlled divergent reactions to synthesize three different classes of medium-sized bicyclic compounds from the same starting materials  >>

<< Intermolecular higher-order cycloaddition, in which two starting materials are 'stitched' together at both ends, provides great potential to build complex cyclic compounds from simple building blocks. Unfortunately, such transformations to prepare medium-sized rings are often plagued with competitive reaction pathways and low levels of site- and stereo-selectivity >>

<< The most significant aspect of this chemistry was that not one, but three different classes of bicyclic medium-sized ring compounds were obtained with high efficiency and stereo-selectivity from the same set of starting molecules.  >>

Divergent synthesis of bicyclic medium-sized ring structures. National University of Singapore. Oct 26, 2020.

https://phys.org/news/2020-10-divergent-synthesis-bicyclic-medium-sized.html

Li-Cheng Yang, Ya-Nong Wang, et al. Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions. Nat. Chem. 12, 860–868. doi: 10.1038/ s41557-020-0503-7. July 27, 2020. 

https://www.nature.com/articles/s41557-020-0503-7