# s-cells: disassembling to create undifferentiated (stem) entities

AA << have  published a study demonstrating how specialized proteins are  able to  change  the identity, or cellular  characteristics,  of skin cells and  create induced  pluripotent  stem cells, which have  the ability to turn into  any cell type  in  the  body. >>

Mirabai Vogt-James. Study pinpoints how skin cells' identity can be disassembled to create stem cells. Jan 20, 2017.

https://m.phys.org/news/2017-01-skin-cells-identity-disassembled-stem.html

<< Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. >>

Constantinos Chronis, Petko Fiziev, Bernadett Papp et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming. Cell (2017). DOI: 10.1016/j.cell.2016.12.016 Publ. Jan.19, 2017

http://www.cell.com/cell/abstract/S0092-8674(16)31730-5

# s-acad: null results also to be published

<< Translational Behavioral Medicine, a major scientific behavioral medicine journal, now publishes research studies that have null results. >>

<< Some in the scientific community view null results research as a failure because, by its very definition, a null result means what you expected would happen in your study did not happen. >>

<< But Translational Behavioral Medicine (TBM) Editor-in-Chief Suzanne Miller-Halegoua, PhD, disagrees with that assessment. >>

Lindsay Bullock. Null results research now published by major behavioral medicine journal. Jan 3, 2017

https://scienmag.com/null-results-research-now-published-by-major-behavioral-medicine-journal/

http://www.springer.com/medicine/journal/13142

# s-evol: an ancient marine subtle cracking: the retroviral lineage from early Paleozoic

AA << phylogenetic  analyses  suggest  that  this  major  retroviral  lineage, and  therefore  retroviruses  as  a  whole,  have  an  ancient  marine origin  and  originated  together  with,  if  not  before,  their  jawed vertebrate  hosts  >450  million  years  ago  in  the  Ordovician  period, early  Palaeozoic  Era. >>

Pakorn  Aiewsakun,  Aris  Katzourakis. Marine  origin  of  retroviruses  in  the early  Palaeozoic  Era. Nature  Communications 8 , Article  number:  13954  (2017) doi :10.1038/ncomms13954. 10  Jan. 2017.

http://www.nature.com/articles/ncomms13954

# s-ageing: epigenetic regulation of ageing

<< In  vitro  cellular reprogramming through the expression of the four transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) has been shown to ameliorate age-associated cellular phenotypes, including gene  expression  profiles,  telomere length and oxidative stress >>

Kim Baumann. Forever young. Nature Reviews Molecular Cell Biology. Publ online 5 Jan 2017; doi:10.1038/nrm.2016.176

http://www.nature.com/nrm/journal/vaop/ncurrent/full/nrm.2016.176.html

# n-trade: 'free' global trade (with gov central command) does not hurt; do not worry, west ...

Jane Cai, Wendy Wu. Don't blame globalisation for world's ills, Xi Jinping tells Davos. Publ. 17 Jan., 2017 5:23pm

http://m.scmp.com/news/china/economy/article/2062840/watch-xi-jinping-live-davos

# s-evol: just three traits to explain, by Tereza & John

AA << found that just three traits explained most variation in diversification and species numbers among phyla: the most successful phyla have a skeleton (either internal or external), live on land (instead of in the ocean), and parasitize other organisms. >>

<< Other traits, including those that might seem more dramatic, had surprisingly little impact on diversification and species numbers: evolutionary accomplishments such as having a head, limbs, and complex organ systems for circulation and digestion don't seem to be primary accessories in the evolutionary "dress for success."  >>

<< "Parasitism isn't correlated with any of the other traits, so it seems to have a strong effect on its own," said Wiens [John Wiens]. >>

How to be winner in the game of evolution. Jan. 13, 2017

https://m.phys.org/news/2017-01-winner-game-evolution.html

Tereza Jezkova, John J. Wiens. What Explains Patterns of Diversification and Richness among Animal Phyla? The American Naturalist (2017). DOI: 10.1086/690194

http://www.journals.uchicago.edu/doi/10.1086/690194

# n-trade: they are wasting time and money to save, by Albert

<<  Italy is in the midst of a serious banking crisis, but the government is wasting both time and money trying to save the country's struggling lenders >>

<< the sector's mountains of bad loans are only a symptom , not the cause of Italy's problems >>

<< Italy is totally moribund >>

Société Générale strategist Albert Edwards.

Sara Sjolin. Permabear Edwards: 'Waste of time' to save Italian banks. Publ. Jan 13, 2017 2:45 am

http://www.marketwatch.com/story/permabear-edwards-waste-of-time-to-save-italian-banks-2017-01-12

More:

<< le banche italiane sono rischiose come quelle di Turchia, Thailandia, Irlanda e Brasile e (..)  il loro livello di rischio è superiore a quello delle banche polacche e spagnole >>

<< stiamo parlando di uno stock intorno ai 260 miliardi >> Mirko Sanna, S&P.

Laura Naka Antonelli. Banche italiane, S&P: “rischiose come quelle di Brasile e Turchia”. 13 Gen 2017

http://www.wallstreetitalia.com/banche-italiane-sp-rischiose-come-quelle-di-brasile-e-turchia/