To [AA] << knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. >>
Palhano-Fontes F, Barreto D, et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2018 Jun 15:1-9. doi: 10.1017/S0033291718001356.
https://www.ncbi.nlm.nih.gov/pubmed/29903051
<< Ayahuasca is a mixture of herbs, traditionally used for spiritual and therapeutic purposes. The main active ingredients are N,N-DMT, a potent psychedelic, and several molecules that inhibit the enzyme MAO. The MAO inhibitors serve to prevent the N,N-DMT from being broken down by the digestive system, allowing it to enter the bloodstream and cause hallucinations and other alterations of consciousness. >>
Ayahuasca, the Psychedelic Antidepressant? Neuroskeptic. June 17, 2018.
http://blogs.discovermagazine.com/neuroskeptic/2018/06/17/psychedelic-antidepressant-ayahuasca/
John Horgan. Yes, Make Psychedelics Legally Available, but Don't Forget the Risks. SciAm. July 6, 2018.
https://blogs.scientificamerican.com/cross-check/yes-make-psychedelics-legally-available-but-dont-forget-the-risks/
Also:
"magic string"
# pharma: waiting for new 'magic strings': psilocybin to treat depression. Oct 17, 2017.
https://flashontrack.blogspot.com/2017/10/pharma-waiting-for-new-strings.html
# s-brain: 70-years after; Dr. Albert revisited. Aug 22, 2016.
https://flashontrack.blogspot.com/2016/08/s-brain-70-years-after-dr-albert.html
# s-pharma-n-ethnomed: psilocybin. Dec 14, 2015.
https://flashontrack.blogspot.com/2015/12/s-pharma-n-ethnomed-psilocybin.html