<< In the many scientific endeavors that are driven by organic chemistry, unambiguous identification of small molecules is of paramount importance (..) the unambiguous determination of a small molecule’s structure requires X-ray and/or neutron diffraction studies. In practice, however, X-ray crystallography is rarely applied in routine organic chemistry due to intrinsic limitations of both the analytes and the technique. >>
AA << report the use of the CryoEM (cryo-electron microscopy) method MicroED (micro-electron diffraction) to provide routine and unambiguous structural determination of small organic molecules. >>
Christopher G. Jones, Michael W. Martynowycz, et al. The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination. ChemRxiv Oct 17, 2018 doi: 10.26434/chemrxiv.7215332.v1
https://chemrxiv.org/articles/The_CryoEM_Method_MicroED_as_a_Powerful_Tool_for_Small_Molecule_Structure_Determination/7215332
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