giovedì 25 maggio 2017

# s-chem: a strange allosteric regulation by volume fluctuations

<< a typical globular protein [the synaptic protein PSD-95] is able to undergo significant changes in volume under native conditions while exhibiting no additional changes in protein structure.These native state volume fluctuations were found to correlate with changes in internal motions that were previously recognized as a source of allosteric entropy. This finding offers a novel mechanistic basis for allostery in the absence of canonical structural change. >>

Anthony B. Law, Paul J. Sapienza, et al. Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery. J. Am. Chem. Soc. 2017, 139 (10), pp 3599–3602 doi: 10.1021/jacs.6b12058

Jeff  Hansen. 'Rosetta Stone' protein offers new mechanism  of allostery.  May 24, 2017

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