# s-pnei: how social status alters immune function in macaques

<< Americans differ in life expectancy by more than a decade. Glaring health inequalities across the socioeconomic spectrum are often attributed to access to medical care and differences in habits such as smoking, exercise and diet. But a new study in rhesus monkeys shows that the chronic stress of life at the bottom can alter the immune system even in the absence of other risk factors. The research confirms previous animal studies suggesting that social status affects the way genes turn on and off within immune cells >>

Upward mobility boosts immunity in monkeys. Nov. 24, 2016

http://m.phys.org/news/2016-11-upward-mobility-boosts-immunity-monkeys.html

AA << combined genomics with a social status manipulation in female rhesus macaques to investigate how status alters immune function >>

AA << identify specific transcription factor signaling pathways that explain these differences, including low-status–associated polarization of the Toll-like receptor 4 signaling pathway toward a proinflammatory response >>

Noah Snyder-Mackler, Joaquin Sanz et al. Social status alters immune regulation and response to infection in macaques. Science  25 Nov 2016: Vol. 354, Issue 6315, pp. 1041-1045 DOI: 10.1126/science.aah3580

http://science.sciencemag.org/content/354/6315/1041