lunedì 27 agosto 2018

# drugs: proteins found in tick saliva (Rhipicephalus and Amblyomma) to treat a potentially fatal form of heart disease

<< Tick saliva contains proteins [evasins] that suppress chemokine-driven inflammation by binding and neutralizing multiple chemokines simultaneously, helping them to suck blood for several weeks without eliciting inflammation. >>

Kamayani Singh, Graham Davies, et al.  Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine - binding activities. Scientific Reports. Jun 27, 2017; 7 (4267).

https://www.nature.com/articles/s41598-017-04378-1

AA << has identified several new tick evasins and shown that one of them, P991_AMBCA, from the cayenne tick found in the Americas, can bind to and block the effect of chemokines which cause inflammation in myocarditis, heart attack and stroke. >>

From bug to drug - tick saliva could be key to treating heart disease. University of Oxford. Jun 27, 2017.

https://m.phys.org/news/2017-06-bug-drugtick-saliva-key-heart.html

Also: "saliva" in:

https://flashontrack.blogspot.com/search?q=saliva

https://inkpi.blogspot.com/search?q=saliva

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