# brain: a way to prevent over-firing NMDA receptors ... "it really comes down to chemistry"

<< The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects. This concept is especially important when treating the delicate and complex human brain. Now, scientists at Cold Spring Harbor  Laboratory have revealed a mechanism that could lead to this kind of long-sought specificity for treatments of strokes and seizures. >>

<< it really comes down to chemistry >> Hiro Furukawa.

Brian Stallard. Targeting 'hidden pocket' for treatment of stroke and seizure. Cold Spring Harbor Laboratory.  Jan 19, 2019.

https://m.phys.org/news/2019-01-hidden-pocket-treatment-seizure.html

Michael C. Regan, Zongjian Zhu, et al. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Comm. 10 (321). Jan 18, 2019 doi: 10.1038/s41467-019-08291-1

https://www.nature.com/articles/s41467-019-08291-1