<< MPST gene expression (which leads to hydrogen sulphide production) was higher in postmortem brains from people with schizophrenia than in those from unaffected people. MPST protein levels in these brains also correlated well with the severity of premortem symptoms. >>
AA << examined hair follicles from more than 150 people with schizophrenia and found that expression of MPST mRNA was much higher than people without schizophrenia. Even though the results were not perfect-indicating that sulfide stress does not account for all cases of schizophrenia-MPST levels in hair could be a good biomarker for schizophrenia before other symptoms appear. >>
<< Nobody has ever thought about a causal link between hydrogen sulfide and schizophrenia, (..) Once we discovered this, we had to figure out how it happens and if these findings in mice would hold true for people with schizophrenia. >> Takeo Toshikawa.
Biomarker for schizophrenia can be detected in human hair. Riken. Oct 28, 2019.
https://medicalxpress.com/news/2019-10-biomarker-schizophrenia-human-hair.html
Masayuki Ide, Tetsuo Ohnishi, et al.
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO Mol Med (2019) e10695. doi: 10.15252/emmm.201910695. Oct 28, 2019.
https://www.embopress.org/doi/full/10.15252/emmm.201910695
