# brain: a way to prevent over-firing NMDA receptors ... "it really comes down to chemistry"

<< The ideal drug is one that only affects the exact cells and neurons it is designed to treat, without unwanted side effects. This concept is especially important when treating the delicate and complex human brain. Now, scientists at Cold Spring Harbor  Laboratory have revealed a mechanism that could lead to this kind of long-sought specificity for treatments of strokes and seizures. >>

<< it really comes down to chemistry >> Hiro Furukawa.

Brian Stallard. Targeting 'hidden pocket' for treatment of stroke and seizure. Cold Spring Harbor Laboratory.  Jan 19, 2019.

https://m.phys.org/news/2019-01-hidden-pocket-treatment-seizure.html

Michael C. Regan, Zongjian Zhu, et al. Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nature Comm. 10 (321). Jan 18, 2019 doi: 10.1038/s41467-019-08291-1

https://www.nature.com/articles/s41467-019-08291-1

# behav: outrage does not make revolution

<< If you're angry about the political feud that drove the federal government to partially shut down, or about a golden parachute for a CEO who ran a business into the ground, you aren't alone-but you probably won't do much about it, according to new research by Carnegie Mellon University's Tepper School of Business. >>

Relying on karma: Research explains why outrage doesn't usually result in revolution. Carnegie Mellon University.  Jan 15, 2019

https://m.phys.org/news/2019-01-karma-outrage-doesnt-result-revolution.html

<< Across four experiments, (AA) show that people respond quite differently to correct these two types of injustices. When bad things happen to good people, individuals are eager to compensate a good person’s losses, but only do so to a small degree. In contrast, when a good thing happens to a bad person, because the only perceived appropriate act of punishment is to fully strip the bad actor of all his or her illegitimate gains, few people choose to punish in this costly way. However, when they do, they do so to very large degrees. Moreover, we demonstrate that differential psychological mechanisms drive this asymmetry. >>

Jeff Galak, Rosalind M. Chow. Compensate a little, but punish a lot: Asymmetric routes to restoring justice.   PLoS ONE 14(1): e0210676. Jan 10, 2019. doi:10.1371/journal.pone.0210676

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210676

# gst: it does not seem either completely chaotic, nor completely organized

<< Contrary to prevailing theories, the first results of POLAR reveal that the high energy photons coming from gamma ray bursts are neither completely chaotic, nor completely organized, but a mixture of the two.  Within short time intervals, the photons are found to oscillate in the same direction, but the oscillation direction changes with time. >>

The orderly chaos of black holes. University of Geneva. Jan 14, 2019.

https://m.phys.org/news/2019-01-orderly-chaos-black-holes.html

Shuang-Nan Zhang, Merlin Kole, et al. Detailed polarization measurements of the prompt emission of five gamma-ray bursts. Nature Astronomy (2019) Jan 14 doi: 10.1038/s41550-018-0664-0

https://www.nature.com/articles/s41550-018-0664-0

# evol: nonlinear effects in shaping human evolution, the role of viruses

<< Human evolution used to be depicted as a straight line, gradually progressing from an ape-like ancestor to modern Homo sapiens. But thanks to next-generation sequencing, findings in recent years have shown that it wasn’t quite so orderly. Now, a new study is reporting new details about the role of viruses in shaping evolution, in particular, viral interactions between modern humans and Neanderthals. >>

<< Many Neanderthal sequences have been lost in modern humans, but some stayed and appear to have quickly increased to high frequencies at the time of contact, suggestive of their selective benefits at that time, >> Dmitri Petrov

New study reports the role of viruses in shaping evolution. Oct 5, 2018.

https://thesurg.com/virus-shaping-evolution

AA << hypothesized that interbreeding between Neanderthals and modern humans led to (1) the exposure of each species to novel viruses and (2) the exchange of adaptive alleles that provided resistance against these viruses. >>

David Enard, Dmitri A. Petrov. Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans. Cell. 175 (2) P360-371.E13 Oct 4, 2018.

https://www.cell.com/cell/fulltext/S0092-8674(18)31095-X 

# acad: producing better research from diversity.

<< Improving the participation of under-represented groups is not just fairer - it could produce better research. >>

<< some studies suggest that a team with a good mix of perspectives is associated with increased productivity. >>

Editorial. Science benefits from diversity. Nature 558, 5 (2018). Jun 6. doi: 10.1038/d41586-018-05326-3

https://www.nature.com/articles/d41586-018-05326-3 

Kendall Powell. These labs are remarkably diverse -  here’s why they’re winning at science. Nature 558, 19-22 (2018) Jun 6. doi: 10.1038/d41586-018-05316-5.

https://www.nature.com/articles/d41586-018-05316-5

# gst: how two chaotic systems can synchronize

<< For the first time the researchers were able to measure the fine grain process that leads from disorder to synchrony, discovering a new kind of synchronization between chaotic systems. They call this new phenomenon Topological Synchronization. >>

<< Chaotic systems, although unpredictable, still have a subtle global organization called strange attractor (..) Every chaotic system attracts its own unique strange attractor. By Topological Synchronization we mean that two strange attractors have the same organization and structures. At the beginning of the synchronization process, small areas on one strange attractor have the same structure of the other attractor, meaning that they are already synced to the other attractor. At the end of the process, all the areas of one strange attractor will have the structure of the other and complete Topological Synchronization has been reached. >> Nir Lahav.

Scientists reveal for first time the exact process by which chaotic systems synchronize. Bar-Ilan University. Jan 7, 2019.

https://m.phys.org/news/2019-01-scientists-reveal-exact-chaotic-synchronize.html

Nir Lahav, Irene Sendina-Nadal, et al.
Synchronization of chaotic systems: A microscopic description. Phys. Rev. E 98, 052204. Nov 6, 2018. doi: 10.1103/PhysRevE.98.052204

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.98.052204

# potus: breaking with singularity within the 2020 race, "don'tvoteJohn", absolutely&anzicheforse ...

John McAfee' << campaign platform contains one item: how do we free ourselves from a government that no longer serves us, but instead has become our master - controlling our every action, down to the detail of what we may or may not put into our bodies and minds. >>  Jan 10, 2019 20:00 CET

"don'tvotemcafee"

https://mcafee2020hq.com

Also

<< Hey John, I'm going to an interview at Mcafee tomorrow for an internship. Any tips? >> 15:22 Jan 8, 2019  https://twitter.com/OsrsMarius/status/1082643757273677824

<< Yes. Keep your mouth shut. They will hire you. And don't mention the allegations that the Founder ate those 9 small Children in Cincinnati back in 1994. I was framed. I don't even like small children. Taste too much like pork.>> 15:26 Jan 8, 2019 https://twitter.com/officialmcafee/status/1082644647225094145

Also

"mcafee"

https://flashontrack.blogspot.com/search?q=mcafee

"potus"

https://flashontrack.blogspot.com/search?q=potus