# age: senolytics, to stay young kill zombie cells

<< Killing off cells that refuse to die on their own has proved a powerful anti-ageing strategy in mice. Now it's about to be tested in humans >>

<< Surprisingly, senescent cells turn out to be slightly different in each tissue. They secrete different cytokines, express different extracellular proteins and use different tactics to avoid death. That incredible variety has made it a challenge for labs to detect and visualize senescent cells >> Judith Campisi.

<<  In young mice, no more than 1% of cells in any given organ were senescent. In two-year-old mice, however, up to 20% of cells were senescent in some organs.  But there's a silver lining to these elusive twilight cells: they might be hard to find, but they're easy to kill >> Valery Krizhanovsky.

<< I think senolytics are drugs that could come soon and be effective in the elderly now, even in the next few years >> Nir Barzilai.

To stay young, kill zombie cells. Nature 2017; 550: 448 – 50. doi:10.1038/550448a Oct 26, 2017

https://www.nature.com/news/to-stay-young-kill-zombie-cells-1.22872