<< Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. >>
<< What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects? >> Ron O. Dror.
<< Dror's team describes discoveries that could be used to minimize or eliminate side effects in a broad class of drugs that target G protein-coupled receptors, or GPCRs. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of all prescription drugs, including antihistamines, beta blockers and opioids. So important is this molecular mechanism that Stanford professor Brian Kobilka shared the 2012 Nobel Prize in Chemistry for his role in discovering how GPCRs work. >>
Tom Abate. What if we could design powerful drugs without unwanted side effects? Stanford University. May 19, 2020.
The << work could provide a framework for the rational design of drugs that are more effective and have fewer side effects. >>
Carl-Mikael Suomivuori, Naomi R. Latorraca, et al. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science.
Vol. 367, Issue 6480, pp. 881-887
doi: 10.1126/ science.aaz0326. Feb 21, 2020.
Also
keyword 'magic' in FonT
keyword 'GPCR' in Wikipedia
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