# brain: waiting for 'magic strings', psilocybin is a 'relatively safe' drug.

<< Psilocybin-containing mushrooms are used for recreational, spiritual, self-development and therapeutic purposes. However, physiologically relatively nontoxic, adverse reactions are occasionally reported. >>

The << study investigated the 12-month prevalence and nature of magic mushroom-related adverse reactions resulting in emergency medical treatment seeking in a global sample of (9.233) people reporting magic mushroom use. >>️

️

️ << The results confirm psilocybin mushrooms are a relatively safe drug, with serious incidents rare and short lasting. Providing harm-reduction information likely plays a key role in preventing adverse effects. More research is needed to examine the detailed circumstances and predictors of adverse reactions including rarer physiological reactions. >>️

Emma I Kopra, Jason A Ferris, et al. Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms. Journal of Psychopharmacology. 1-9. doi: 10.1177/ 02698811221084063. 

Apr 7, 2022.

https://journals.sagepub.com/doi/full/10.1177/02698811221084063

<< Psilocybin is currently being investigated in clinical trials for mental health conditions across the world, including in our department, (..) It is important to draw a distinction between the use of psilocybin in clinical or research settings and recreational magic mushroom use, with partly overlapping yet distinct safety considerations and risk profiles. >> Emma Kopra. 

Beth Ellwood. Large survey suggests psilocybin is a “relatively safe” drug, with serious reactions being rare and short-lived. May 4, 2022. 

https://www.psypost.org/2022/05/large-survey-suggests-psilocybin-is-a-relatively-safe-drug-with-serious-reactions-being-rare-and-short-lived-63075

Also

keyword 'magic string' in FonT

https://flashontrack.blogspot.com/search?q=magic+string

keyword 'psychedelic' in FonT

https://flashontrack.blogspot.com/search?q=psychedelic

Keywords: brain, drugs, magic string, magic mushrooms, psilocybin, psychedelic

# gst: apropos of transitions among granular entities, the behavior of silicone-coated sand mixtures (the 'magic sand')

<< Sand is a fascinating material. It can flow and be poured like a liquid, but retains many of the properties of solids, clogging pipes or forming sand dunes. (..) Grains interact via simple, Newtonian mechanics, but because so many particles are interacting at once, there is an emergent complexity of flow behavior that cannot yet be explained by simple equations. Scientists are thus not only looking for better theoretical models to explain granular behavior, but convenient "model systems" that can be handled and tuned in the lab to give insights into how the microscopic structure of granular materials gives rise to their macroscopic properties. >>️️

<< A team (..) has studied the properties of mixtures of silicone-coated "magic sand," a popular kids' toy, and normal sand. Silicone-coated sand particles were found to interact only with each other and not with other sand particles. The team discovered that adding silicone-coated sand beyond a certain threshold leads to an abrupt change in clustering and rigidity, a potential way to tune the flow of granular materials for industry.>>️

<< Using three independent methods involving sieving, measuring density and forming stable mounds of sand, they found that the mechanical properties of the mixture changes drastically when the fraction of magic sand to normal sand exceeds 20%. This agreed with findings from percolation theory, which governs how connections between particles span space without any breakages, letting the sand mixture behave in a significantly more solid-like way and bear its own weight. This behavior is known for polymer gels, and helps unify theoretical approaches applied to completely different materials. The team's mixtures also exhibits mechanical properties that can be easily modified. Importantly, the method provides a new, convenient, accurate and informative way to explore granular physics, >>️

️

'Magic sand' might help us understand the physics of granular matter. Tokyo Metropolitan University. Mar 08, 2021.

https://phys.org/news/2021-03-magic-sand-physics-granular.html

️

Marie Tani, Honoka Fujio, Rei Kurita. Transition Behavior in Silicone-coated Sand Mixtures. Journal of the Physical Society of Japan. 90 (3): 033801. doi: 10.7566/ JPSJ.90.033801.

https://journals.jps.jp/doi/10.7566/JPSJ.90.033801

Also

keyword 'grain' in FonT

https://flashontrack.blogspot.com/search?q=grain

keyword 'sand' in FonT

https://flashontrack.blogspot.com/search?q=sand

keyword 'sand' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=sand

keyword 'sabbia' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=sabbia

keyword 'grani' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=grani

# life; Hollywood (movies) revisited, you must be aware of the fact that Alien Entities will share our planet with us and, marginally, ...

Hollywood (movies) revisited, you must be aware of the fact that Alien Entities will share our planet with us and, marginally, will modify our neurobiology with physiological 'magic strings' virus-injected (*) to 'gently' subdue us.  Are you ready for all this, anzicheforse?

(*) virus-injected approach, motivated by the fact that Terrestrials use NOT to attack retroviruses with 'pastroky' vaccines ...

Also

<< David (Leonard David) said that extraterrestrials, however, could be aware of us and be deliberately ignoring our planet, which would represent an equally devastating blow to the human sense of self-importance. >>

️

<< We could be the dolts of the universe. >> Leonard David. 

️

 UFOs ‘Something’s coming’: is America finally ready to take UFOs seriously? Adam Gabbatt in New York

@adamgabbatt Sat 5 Feb 2022 08.00 GMT 

 https://www.theguardian.com/world/2022/feb/05/ufos-america-aliens-government-report

Also

keyword 'alien' | 'ufo' | 'esobio' in FonT

https://flashontrack.blogspot.com/search?q=alien

https://flashontrack.blogspot.com/search?q=ufo

https://flashontrack.blogspot.com/search?q=esobio

keyword 'alieno' | 'ufo' in Notes  (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=alieno

https://inkpi.blogspot.com/search?q=ufo

keyword 'oops' in FonT

https://flashontrack.blogspot.com/search?q=oops

keyword 'magic string' in FonT

https://flashontrack.blogspot.com/search?q=magic+string

Also

Dr. J. Allen Hynek (Astronomer, the scientific consultant of the U.S. Air Force Project Sign (1948), Project Grudge (1949), Blue Book (1952–1969).

https://en.m.wikipedia.org/wiki/J._Allen_Hynek 

PS:  io non sono mai stato testimone di alieni o di manifestazioni di entità aliene. Tuttavia, forse (qui sottolineo forse), potrei averne frequentata una per decenni. Mia madre era per me una incognita; beveva l'essenziale, non fumava, non dormiva, mangiava poco, non si ammalava, era sempre in energico movimento. Passati i novanta anni di età - grondante di sudore, dopo avere trascorso, giusto per passare il tempo, un paio di ore a stirare nel mezzogiorno della calura agostana riminese - qualche volta l'ho sentita pronunciare la frase: "andrò a coricarmi perchè mi sento un po' stanca". Quando lei entrava in una stanza io immaginavo che virus e batteri sarebbero fuggiti terrorizzati per cercare di evitare quello che di lì a poco sarebbe potuto succedere. Lei era impermeabile a qualsivoglia ideologia o argomentazione che non si traducesse in immediata modalità operativa. Quale (apparente) paradosso, per lei era anche normale individuare e ribaltare immediatamente i punti chiave in merito a qualsiasi argomento. Anche se non lo dava a vedere, era una persona sostanzialmente avversa a qualsivoglia autorità imposta. Ricordo bene che le uniche tesi che non aggrediva erano quelle che trattavano la musica blues, il jazz, il rock - forse perchè intuiva che tali approcci fossero per sè stessi fondamentalmente auto-ribaltanti - e la chimica che, anche quando poteva contenere aspetti meramente speculativi, fantasmatici, lei avrebbe potuto comunque scorgere qualche indispensabile componente operativa osservazionale- sperimentale. 

Per questa sua unicità, dall'età di dieci anni fino ai quindici, ho avuto il sospetto che lei potesse essere il prodotto di qualche ignoto esperimento alieno. 

A distanza di decenni penso che mia madre, sebbene da bambina le avessero imposto di conseguire la sola istruzione elementare - come peraltro molte della sua generazione, sarebbe stata (terrestre o aliena) un valido 'naturale' co-addestratore nel team di una scuola Shaolin.

keywords: UFO, UFOs, UAP, EBE ,

AATIP, UAPTF ,OVNI , virus,  magic string, aliens, esobio, exobiology

# pharma: drawing 'magic strings' for GPCRs

<< Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. >>

<< What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects? >> Ron O.  Dror. 

<< Dror's team describes discoveries that could be used to minimize or eliminate side effects in a broad class of drugs that target G protein-coupled receptors, or GPCRs. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of all prescription drugs, including antihistamines, beta blockers and opioids. So important is this molecular mechanism that Stanford professor Brian Kobilka shared the 2012 Nobel Prize in Chemistry for his role in discovering how GPCRs work. >>

Tom Abate. What if we could design powerful drugs without unwanted side effects? Stanford University.  May 19, 2020.

https://phys.org/news/2020-05-powerful-drugs-unwanted-side-effects.html    

The << work could provide a framework for the rational design of drugs that are more effective and have fewer side effects. >>

Carl-Mikael Suomivuori, Naomi R. Latorraca, et al. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science. 

Vol. 367, Issue 6480, pp. 881-887

doi: 10.1126/ science.aaz0326. Feb 21, 2020.

https://science.sciencemag.org/content/367/6480/881   

Also

keyword 'magic' in FonT

https://flashontrack.blogspot.com/search?q=magic

keyword 'GPCR'  in Wikipedia

https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor

# pharma: waiting for new 'magic strings': psilocybin to treat depression

AA << data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients [..] A ‘reset’ therapeutic mechanism is proposed >>

Robin L Carhart-Harris, Leor Roseman, et al. Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep  2017; 7 (13187) doi: 10.1038/s41598-017-13282-7

https://www.nature.com/articles/s41598-017-13282-7

<< Patients taking psilocybin to treat depression show reduced symptoms weeks after treatment following a 'reset' of their brain activity >>

Ryan O'Hare. Magic mushrooms may 'reset' the brains of depressed patients. Oct 13, 2017.

http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_12-10-2017-16-22-36

'Magic mushrooms' may 'reset' the brains of depressed patients, study suggests. Oct 13, 2017

https://www.sciencedaily.com/releases/2017/10/171013091018.htm

to update:

https://www.ncbi.nlm.nih.gov/pubmed/?term=psilocybin

# brain: naturally-occurring psychedelic DMT, a 'magic string' endogenously synthesized

AA << results show for the first time that the rat brain is capable of synthesizing and releasing DMT [N,N-dimethyltryptamine] at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains. >>

Jon G. Dean, Tiecheng Liu, et al.  Biosynthesis and Extracellular Concentrations of N,N- dimethyltryptamine (DMT) in Mammalian Brain. Scientific Reports. volume 9, Article number: 9333 (2019).  Jun 27, 2019.

https://www.nature.com/articles/s41598-019-45812-w

'Mystical' psychedelic compound found in normal brains. University of Michigan. Jun 27, 2019.

https://m.medicalxpress.com/news/2019-06-mystical-psychedelic-compound-brains.html  

Also

'magic strings', in: FonT

https://flashontrack.blogspot.com/search?q=magic+strings

# pharma: an ethno-drug revisited ... Ayahuasca, prelude of a "magic string" in neuropharmacology

To [AA] << knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. >>

Palhano-Fontes F, Barreto D, et al.  Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2018 Jun 15:1-9. doi: 10.1017/S0033291718001356.

https://www.ncbi.nlm.nih.gov/pubmed/29903051

<< Ayahuasca is a mixture of herbs, traditionally used for spiritual and therapeutic purposes. The main active ingredients are N,N-DMT, a potent psychedelic, and several molecules that inhibit the enzyme MAO. The MAO inhibitors serve to prevent the N,N-DMT from being broken down by the digestive system, allowing it to enter the bloodstream and cause hallucinations and other alterations of consciousness. >>

Ayahuasca, the Psychedelic Antidepressant? Neuroskeptic. June 17, 2018.

http://blogs.discovermagazine.com/neuroskeptic/2018/06/17/psychedelic-antidepressant-ayahuasca/

John Horgan. Yes, Make Psychedelics Legally Available, but Don't Forget the Risks. SciAm. July 6, 2018.

https://blogs.scientificamerican.com/cross-check/yes-make-psychedelics-legally-available-but-dont-forget-the-risks/

Also:

"magic string"

# pharma: waiting for new 'magic strings': psilocybin to treat depression. Oct 17, 2017.

https://flashontrack.blogspot.com/2017/10/pharma-waiting-for-new-strings.html

# s-brain: 70-years after; Dr. Albert revisited. Aug 22, 2016.

https://flashontrack.blogspot.com/2016/08/s-brain-70-years-after-dr-albert.html

# s-pharma-n-ethnomed: psilocybin. Dec 14, 2015.

https://flashontrack.blogspot.com/2015/12/s-pharma-n-ethnomed-psilocybin.html

# n-behav: sometimes, mess is better

<< Sometimes, mess is better than order and precision >>

<< By breaking the rigidity of rules, we expose ourselves to unexpected twists and turns which push us to come up with creative, innovative and improvised ideas and answers >> Tim Harford

Pooja  Singh. The  magic  in  mess.  In this  volatile business world, can a  little messiness help spur creativity? Sun,  Jan  22  2017.  04  15  PM

http://www.livemint.com/Leisure/qo2FKT6SQzkl5onbbtqEML/The-magic-in-mess.html

# ai: perpetual nirvana among 'self-addicted', 'self-cracked', 'playful' machines, the wireheading effect.

<< In 1953, a Harvard psychologist thought he discovered pleasure – accidentally – within the cranium of a rat. With an electrode inserted into a specific area of its brain, the rat was allowed to pulse the implant by pulling a lever. It kept returning for more: insatiably, incessantly, lever-pulling. In fact, the rat didn’t seem to want to do anything else. Seemingly, the reward centre of the brain had been located. >>️

<< More than 60 years later, in 2016, a pair of artificial intelligence (AI) researchers were training an AI to play video games. The goal of one game – Coastrunner – was to complete a racetrack. But the AI player was rewarded for picking up collectable items along the track. When the program was run, they witnessed something strange. The AI found a way to skid in an unending circle, picking up an unlimited cycle of collectables. It did this, incessantly, instead of completing the course. >>️

<< What links these seemingly unconnected events is something strangely akin to addiction in humans. Some AI researchers call the phenomenon "wireheading". >>️

Thomas Moynihan, Anders Sandberg. Drugs, robots and the pursuit of pleasure – why experts are worried about AIs becoming addicts. The Conversation. Sep 14, 2021. 

https://theconversation.com/drugs-robots-and-the-pursuit-of-pleasure-why-experts-are-worried-about-ais-becoming-addicts-163376

Rock'n Roll Monkey/Unsplash, FAL (img)  

https://images.theconversation.com/files/411932/original/file-20210719-23-1fx0vl0.jpg

FonT: so one could hypothesize a suitable 'magic string' that mitigates hypothetical autocatalytic pulsatile wireheading effects, even for artificial, bio-artificial entities.

An ethno-drug revisited ... Ayahuasca, prelude of a "magic string" in neuropharmacology. FonT.  July 8, 2018.

https://flashontrack.blogspot.com/2018/07/pharma-ethno-drug-revisited-ayahuasca.html

Also

"senza finalita' ideologiche, solo per curiosita',  giusto per giocare ..." in: 

Anomalous formation of molecules after vapor deposition. FonT.  Dec 31, 2015. 

https://flashontrack.blogspot.com/2015/12/rmx-s-gst-anomalous-formation-of.html

A mechanism of analogy could be the master key to achieving an abstract artificial intelligence. FonT. Aug 10, 2021. 

https://flashontrack.blogspot.com/2021/08/aibot-mechanism-of-analogy-could-be.html

keyword 'ia' | 'ai' in Notes (quasi- stochastic poetry)

https://inkpi.blogspot.com/search?q=ia

https://inkpi.blogspot.com/search?q=ai

keywords: ai, bots, artificial intelligence, wireheading effect, addiction

# gene: parental 'memory' could be inherited across generations (2); the happiness project.

<< In public talks and interviews, Mansuy (Isabelle Mansuy) says she's careful not to promise too much. As confident as she is in her mouse model, she says, there's lots more work to be done. "I don't think the field is moving too fast,"  Mansuy says. "I think it's moving too slow." >>

Andrew Curry. Parents’ emotional trauma may change their children’s biology. Studies in mice show how. Science. doi: 10.1126/science.aay7690. Jul. 18, 2019.    https://www.sciencemag.org/news/2019/07/parents-emotional-trauma-may-change-their-children-s-biology-studies-mice-show-how  

Andrew Curry. A painful legacy. Science. Vol. 365, Issue 6450, pp. 212-215. doi: 10.1126/science.365.6450.212. Jul 19, 2019.     https://science.sciencemag.org/content/365/6450/212

Jocelyn Kaiser. The Epigenetics Heretic. Science  Vol. 343, Issue 6169, pp. 361-363. doi: 10.1126/science.343.6169.361.  Jan 24, 2014.    https://science.sciencemag.org/content/343/6169/361   

David Grimm. The happiness project. Science. Vol. 359, Issue 6376, pp. 624-627. doi: 10.1126/science.359.6376.624. Feb 09, 2018.    https://science.sciencemag.org/content/359/6376/624  

Also

parental 'memory' could be inherited across generations. FonT. Jul 22, 2019.  http://flashontrack.blogspot.com/2019/07/gene-parental-could-be-inherited-across.html

'magic string'.  In: FonT.    https://flashontrack.blogspot.com/search?q=magic+string

# pharma: a 'magical' (engineered) Escherichia coli to produce psychedelic psilocybin

<< Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising results in clinical trials for the treatment of addiction, depression, and post-traumatic stress disorder.  >>

AA << present the development of a modular biosynthetic production platform in the model microbe, Escherichia coli. (..) This is the highest psilocybin titer achieved to date from a recombinant organism and a significant step towards demonstrating the feasibility of industrial production of biologically-derived psilocybin. >>

Alexandra M.Adams, Nicholas A.Kaplan, et al. In vivo production of psilocybin in E. coli. Metabolic Engineering. Volume 56, pages 111-9. doi: 10.1016/j.ymben.2019.09.009. Sep 21, 2019.

https://www.sciencedirect.com/science/article/pii/S109671761930309X

Tanya Lewis. E. coli Could Produce a Popular Psychedelic for Therapeutic Use. Scientists engineered the bacterium to produce psilocybin. SCIAM. 322, 1, 16. Jan 2020.

https://www.scientificamerican.com/article/e-coli-could-produce-a-popular-psychedelic-for-therapeutic-use/

Also

keyword 'magic' in FonT

https://flashontrack.blogspot.com/search?q=magic

# s-brain: 70-years after; Dr. Albert revisited

<< Treating an addiction to a mind-altering substance with another mind-altering substance might seem counterintuitive, but more and more, researchers are finding ways that psychedelic drugs like psilocybin mushrooms and party drugs like ketamine could actually help people get over alcohol and drug addictions. >>

Kevin Loria. Science Doctors are talking about using psychedelic drugs to treat alcoholics. 21 Aug 2016.

http://www.businessinsider.com/doctors-using-ketamine-lsd-and-mushrooms-to-treat-mental-illness-2016-8

Zoe  Cormier. Magic-mushroom  drug  lifts  depression  in  first  human trial. Researchers'  long  fight  to  test  psilocybin's  safety  finally  yields  fruit.  Nature.  17  May  2016. doi:10.1038/nature.2016.19919.

http://www.nature.com/news/magic-mushroom-drug-lifts-depression-in-first-human-trial-1.19919

Dr. Albert (Albert Hofmann) in: Lysergic acid diethylamide. 21 Aug 2016.

https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide

# s-brain-behav: the skill to synchronize eye-blinks

<< Magicians  use  several  techniques  to  deceive  their  audiences,  including,  for  example,  the misdirection  of  attention  and  verbal  suggestion.  We  explored  another  potential  stratagem, namely  the  relaxation  of  attention.  Participants  watched  a  video  of  a  highly  skilled  magician whilst  having  their  eye-blinks  recorded.  The  timing  of  spontaneous  eye-blinks  was  highly synchronized  across  participants.  In  addition,  the  synchronized  blinks  frequency  occurred immediately  after  a  seemingly  impossible  feat,  and  often  coincided  with  actions  that  the  magician wanted  to  conceal  from  the  audience.  Given  that  blinking  is  associated  with  the  relaxation  of attention,  these  findings  suggest  that  blinking  plays  an  important  role  in  the  perception  of  magic, and  that  magicians  may  utilize  blinking  and  the  relaxation  of  attention  to  hide  certain  secret actions. >>

Wiseman  RJ,  Nakano  T. Blink  and  you’ll  miss  it:  the  role  of  blinking  in  the perception  of  magic  tricks. PeerJ4:e1873 https://doi.org/10.7717/peerj.1873

https://peerj.com/articles/1873/

# life: apropos of transitions (in visual perceptions), 'when the reasoning mind melts away, only shapes remain'.

<< Those who drink the hallucinogenic ayahuasca report seeing two-dimensional patterns or throbbing, three-dimensional hexahedral cells. When the reasoning mind melts away, only shapes remain. >>

<< Geometry gives us a world unclad. "Euclid alone has looked on Beauty bare," wrote Edna St. Vincent Millay. That feeling of mystical revelation — of a shimmering, underlying order that we can apprehend if we purify our perception — might explain the mutual affinity between poets and geometers.  (..) Many of the mathematicians cited in Ellenberg’s book (Jordan Ellenberg,  'Shape' ) wrote verse. >>

<< “I prove a theorem,” the poet Rita Dove wrote, “and the house expands.” >>️

️

Parul Sehgal. ‘Shape’ Makes Geometry Entertaining. Really, It Does. NYT. May 20, 2021.

https://www.nytimes.com/2021/05/18/books/review-shape-geometry-jordan-ellenberg.html

Jordan Ellenberg. Shape. The Hidden Geometry of Information, Biology, Strategy, Democracy, and Everything Else. 463 pages. Penguin Press.

https://www.nytimes.com/column/books-of-the-times

Also

keyword 'ayahuasca'  | 'magic string' in FonT

https://flashontrack.blogspot.com/search?q=ayahuasca

https://flashontrack.blogspot.com/search?q=magic+string

keyword 'transition' in FonT

https://flashontrack.blogspot.com/search?q=transition

keyword 'transition' | 'transizion*' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=transition

https://inkpi.blogspot.com/search?q=transizione

https://inkpi.blogspot.com/search?q=transizioni

# brain: immagini #CTZ, cicliche fantasmatiche pervasive visioni ricorrenti

<< Vladimir Putin has trumpeted the growth of national populist movements in Europe and America, crowing that liberalism is spent as an ideological force.

In an FT interview in the Kremlin on the eve of the G20 summit in Osaka, Japan, the Russian president said “the liberal idea” had “outlived its purpose” as the public turned against immigration, open borders and multiculturalism. >>

Lionel Barber and Henry Foy in Moscow,  and Alex Barker in Osaka. Vladimir Putin says liberalism has 'become obsolete'. FT. Jun 27, 2019

https://www.ft.com/content/670039ec-98f3-11e9-9573-ee5cbb98ed36 

FonT

i giochi fisiologici che si giocano su questo pianeta (forse anche altrove) sono giochi 'aperti', all'interno dei due vincoli del gioco 'legale' (sostanzialmente i due vincoli del casino' [#1,#2]); al di fuori dei due vincoli non c'e' auto-struttura, auto-funzione, auto- manutenzione, e dove non c'e' auto- manutenzione la speranza di sopravvivenza - in funzione del tempo - di qualsivoglia sistema vivente cala, smorza, scema, declina; questa sembra la realta' funzionale di un sistema complesso dove le interne sub-unita' sono in continua interazione (non lineare); la propensione di entita' CTZ sensibili, specialmente quando costrette a fronteggiare bi/ multi- forcazioni, di ricondurre i punti di riferimento decisionali alle classiche, storiche, rituali  tre 'immagini'  (CTZ,  appunto) - il 'Campanile', la 'Terra', la 'Zappa' (da li' l'anagramma: 'ne Campa il ZappaTerra') - e' sostanzialmente illusoria perche' i tre punti di riferimento CTZ non permettono all'entita' transeunte di risolvere / reimpostare in modo soddisfacente i suoi problemi, veri o presunti tali; talvolta si ha l'illusione di una risoluzione, che sara' tuttavia irreversibilmente instabile rispetto al tempo; il Campanile e' una immagine che per sua intima natura e' relativa, le teoretiche che lo giustificano, lo sostengono, hanno contorni s-fumati, che scricchiolano (evaporano) dalle troppe contraddizioni interne; la Terra 'trema', anch'essa per sua intima natura, e' transitoria, si incendia, congela, sbricciola, frana, si allaga, viene spazzata periodicamente da vortici d'aria, e' sensibile a imponenti  forze esterne, cosmologiche, percio' partecipa attivamente alla  compromissione della stabilita' di qualsivoglia Campanile (Totem, Lampione ...); la Zappa e' per sua intima natura un oggetto 'techno', dipende dallo stato dell'arte tecno-scientifica, e attualmente e' in mutazione verso le graziose forme del 'robota', oggetto prospetticamente autonomo,  fisicamente, neuralmente (culturalmente?) ...

Il bravo (e fortunato) dr. Albert - Albert Hofmann, chimico con il pallino dell'azzardo sperimentale, un classico ... - aveva forse trovato il giusto approccio, la giusta 'medicina' per offrire 'respiro' anche a lungo termine alle moltitudini entita' CTZ-dipendenti (neuralmente, geneticamente dipendenti?), specialmente se e quando  coinvolte in contesti di accidentale modalita' accelerativa transeunte; e' davvero disdicevole che la molecola di Hofmann (LSD [#3]) presenti effetti collaterali non insignificanti; se gli effetti 'epigenetici' sono fisiologicamente troppo lenti per fronteggiare una realta' mutaforma dirompente e pervasiva, allora forse servirebbe una nuova 'magica stringa' [#4] farmacologica o di natura genetica, farmaco-epigenetica, allo scopo di alleviare almeno quegli stati confusionali, depressivi e i comportamenti a-priori lesivi- autolesivi tipici dell'entita' CTZ-dipendenti; anche e senz'altro per quell'altre entita', ben mimetizzate, a loro dire solo apparentemente illusoriamente insensibili a visioni / vincoli CTZ.

Davvero disdicevole accadimento (per i non pochi) lo storico 'salto' dallo 'standard' entita' nomade esploratrice erratica verso il qualcos'altro, ...  non e' vero?

[#1] - Notes. 1809 - strutturanti decisioni. Nov 26, 2004. 

https://inkpi.blogspot.com/2004/11/1809-strutturanti-decisioni.html

[#2] - Notes. 1821 - i due beffardi vincoli. Nov 26, 2004. 

https://inkpi.blogspot.com/2004/11/1821-i-due-beffardi-vincoli.html

[#3] - 'LSD' in: FonT.

https://flashontrack.blogspot.com/search?q=lsd

[#4] - 'magic string' in: FonT. An ethno-drug revisited ... Ayahuasca, prelude of a "magic string" in neuropharmacology. Jul 8, 2018.

https://flashontrack.blogspot.com/2018/07/pharma-ethno-drug-revisited-ayahuasca.html

Also

FonT. JARexit: the ironic probabilistic upshot of the itinerant, escaping IR77, Promobot. Jun 25, 2016.

https://flashontrack.blogspot.com/2016/06/s-bot-jarexit-ironic-probabilistic.html

FonT. The next step of a "liquid society": Jia Jia, they will love "her" ...  Jan 10, 2017.

https://flashontrack.blogspot.com/2017/01/n-soc-next-step-of-society-jia-jia-they.html

# trade: job career quick transitions, from Silicon Valley to the Cannabis Marketplace

<< For decades, those looking to change the world arrived in Silicon Valley seeking the latest frontier: social media companies, gadget makers, delivery and transportation apps, e-commerce platforms. >>

<< But as the emerging markets of yesterday become today's stalwarts, a growing number of technology workers are migrating to an even newer sector-so new that it isn't legal at the federal level. >>

<<  The U.S. cannabis market is expected to grow to $75 billion in sales by 2030 from $10 billion, said Troy Dayton, chief executive of cannabis investment and market research firm Arcview. >>

<< Eaze, which aspires to be something of an Amazon for pot, has raised more than $50 million from tech investors such as DCM and Fresh VC. PAX Labs, whose cannabis vaporizers resemble Apple gadgets, has raised more than $100 million from Silicon Valley and institutional investors. And Baker Technologies, which is essentially a Salesforce for dispensaries, made it into 500 Startups' prestigious accelerator program in 2015. >>

Tracey Lien. They worked at Apple, Amazon and Lyft. Now they're working to get you stoned.  Los Angeles Times. July 17, 2018.

https://m.phys.org/news/2018-07-apple-amazon-lyft-theyre-stoned.html

FonT

quando uno scientist di talento (anche  fortunato) oppure una pulsiva AI oppure entrambi disegneranno la/una "magica stringa" fisiologica, priva di effetti collaterali di rilievo, anche questi lucrosi mercati a iniziativa piu' o meno individuale evaporeranno, io penso ...

"magic string" in:
https://flashontrack.blogspot.com/2018/07/pharma-ethno-drug-revisited-ayahuasca.html

# brain: how the brain says 'Oops!'

AA << have uncovered how signals from a group of neurons in the brain's frontal lobe simultaneously give humans the flexibility to learn new tasks—and the focus to develop highly specific skills. >>

<< The study's key finding is that the brain uses the same group of neurons for performance feedback in many different situations—whether a person is attempting a new task for the first time or working to perfect a specific skill. >>

<< Part of the magic of the human brain is that it is so flexible, (..) We designed our study to decipher how the brain can generalize and specialize at the same time, both of which are critical for helping us pursue a goal. >> Ueli Rutishauser. ️

️

New Study Reveals How the Brain Says 'Oops!'. Cedars-Sinai Medical Center. May 5, 2022. 

https://www.cedars-sinai.org/newsroom/new-study-reveals-how-the-brain-says-oops/

AA << recorded the activity of more than 1000 neurons in the medial frontal cortex of human epilepsy patients while they performed complex cognitive tasks. They found that domain-general and domain-specific performance monitoring neurons were intermixed within this brain region. The population activity gave rise to a geometry that allowed domain-general signals to be read out with more than 90% accuracy on single trials while at the same time retaining the ability to separate different conflict conditions. These results show how the human medial frontal cortex resolves the fundamental trade-off between task generalization and specialization, which is critical for cognitive flexibility. >>

️

Zhongzheng Fu, Danielle Beam, et al. The geometry of domain-general performance monitoring in the human medial frontal cortex. Science. Vol 376, Issue 6593. doi: 10.1126/ science.abm9922. May 6, 2022.

https://www.science.org/doi/10.1126/science.abm9922

Also

keyword 'cervello' | 'brain' in Notes

(quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=cervello

https://inkpi.blogspot.com/search?q=brain

keyword 'brain' in FonT

https://flashontrack.blogspot.com/search?q=brain

keyword 'organoids' in FonT

https://flashontrack.blogspot.com/search?q=organoids

PS: An image of "oops", not completely spanned in the air, could be this:

Keywords: brain, mind, cervello, mente, oops

# s-pharma-n-ethnomed: psilocybin

<< A single dose of psilocybin, the major hallucinogenic component in magic mushrooms, induces long-lasting decreases in anxiety and depression >>

http://www.eurekalert.org/pub_releases/2015-12/acon-aii121015.php

Roland Griffiths, American College of Neuropsychopharmacology.  54^ Annual Meeting 2015, December 6-10.

http://www.acnp.org/annualmeeting/default.aspx

# life: it’s time to admit that ...

<< For too long, scientists have been content in espousing the lazy metaphor of living systems operating simply like machines, (..) Yet, it’s important to be open about the complexity of biology — including what we don’t know — because public understanding affects policy, health care and trust in science.  “So long as we insist that cells are computers and genes are their code,” writes Ball, life might as well be “sprinkled with invisible magic”. But, reality “is far more interesting and wonderful”, as he explains in this must-read user’s guide for biologists and non-biologists alike. >>️

Denis Noble. It’s time to admit that genes are not the blueprint for life. Nature. 626, 254-255 (2024). Feb 5,  2024. 

https://www.nature.com/articles/d41586-024-00327-x

Philip Ball. How Life Works: A User’s Guide to the New Biology. Pan Macmillan (2024). 

https://www.panmacmillan.com/authors/philip-ball/42387

Also: disorder, disorder & fluctuation, in https://www.inkgmr.net/kwrds.html  

Keywords: life, disorder, fluctuations

FonT: this point of view, published in the 70s-80s, would have made a damned impression.