# brain: waiting for 'magic strings', psilocybin is a 'relatively safe' drug.

<< Psilocybin-containing mushrooms are used for recreational, spiritual, self-development and therapeutic purposes. However, physiologically relatively nontoxic, adverse reactions are occasionally reported. >>

The << study investigated the 12-month prevalence and nature of magic mushroom-related adverse reactions resulting in emergency medical treatment seeking in a global sample of (9.233) people reporting magic mushroom use. >>️

️

️ << The results confirm psilocybin mushrooms are a relatively safe drug, with serious incidents rare and short lasting. Providing harm-reduction information likely plays a key role in preventing adverse effects. More research is needed to examine the detailed circumstances and predictors of adverse reactions including rarer physiological reactions. >>️

Emma I Kopra, Jason A Ferris, et al. Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms. Journal of Psychopharmacology. 1-9. doi: 10.1177/ 02698811221084063. 

Apr 7, 2022.

https://journals.sagepub.com/doi/full/10.1177/02698811221084063

<< Psilocybin is currently being investigated in clinical trials for mental health conditions across the world, including in our department, (..) It is important to draw a distinction between the use of psilocybin in clinical or research settings and recreational magic mushroom use, with partly overlapping yet distinct safety considerations and risk profiles. >> Emma Kopra. 

Beth Ellwood. Large survey suggests psilocybin is a “relatively safe” drug, with serious reactions being rare and short-lived. May 4, 2022. 

https://www.psypost.org/2022/05/large-survey-suggests-psilocybin-is-a-relatively-safe-drug-with-serious-reactions-being-rare-and-short-lived-63075

Also

keyword 'magic string' in FonT

https://flashontrack.blogspot.com/search?q=magic+string

keyword 'psychedelic' in FonT

https://flashontrack.blogspot.com/search?q=psychedelic

Keywords: brain, drugs, magic string, magic mushrooms, psilocybin, psychedelic

# brain: naturally-occurring psychedelic DMT, a 'magic string' endogenously synthesized

AA << results show for the first time that the rat brain is capable of synthesizing and releasing DMT [N,N-dimethyltryptamine] at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains. >>

Jon G. Dean, Tiecheng Liu, et al.  Biosynthesis and Extracellular Concentrations of N,N- dimethyltryptamine (DMT) in Mammalian Brain. Scientific Reports. volume 9, Article number: 9333 (2019).  Jun 27, 2019.

https://www.nature.com/articles/s41598-019-45812-w

'Mystical' psychedelic compound found in normal brains. University of Michigan. Jun 27, 2019.

https://m.medicalxpress.com/news/2019-06-mystical-psychedelic-compound-brains.html  

Also

'magic strings', in: FonT

https://flashontrack.blogspot.com/search?q=magic+strings

# life; Hollywood (movies) revisited, you must be aware of the fact that Alien Entities will share our planet with us and, marginally, ...

Hollywood (movies) revisited, you must be aware of the fact that Alien Entities will share our planet with us and, marginally, will modify our neurobiology with physiological 'magic strings' virus-injected (*) to 'gently' subdue us.  Are you ready for all this, anzicheforse?

(*) virus-injected approach, motivated by the fact that Terrestrials use NOT to attack retroviruses with 'pastroky' vaccines ...

Also

<< David (Leonard David) said that extraterrestrials, however, could be aware of us and be deliberately ignoring our planet, which would represent an equally devastating blow to the human sense of self-importance. >>

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<< We could be the dolts of the universe. >> Leonard David. 

️

 UFOs ‘Something’s coming’: is America finally ready to take UFOs seriously? Adam Gabbatt in New York

@adamgabbatt Sat 5 Feb 2022 08.00 GMT 

 https://www.theguardian.com/world/2022/feb/05/ufos-america-aliens-government-report

Also

keyword 'alien' | 'ufo' | 'esobio' in FonT

https://flashontrack.blogspot.com/search?q=alien

https://flashontrack.blogspot.com/search?q=ufo

https://flashontrack.blogspot.com/search?q=esobio

keyword 'alieno' | 'ufo' in Notes  (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=alieno

https://inkpi.blogspot.com/search?q=ufo

keyword 'oops' in FonT

https://flashontrack.blogspot.com/search?q=oops

keyword 'magic string' in FonT

https://flashontrack.blogspot.com/search?q=magic+string

Also

Dr. J. Allen Hynek (Astronomer, the scientific consultant of the U.S. Air Force Project Sign (1948), Project Grudge (1949), Blue Book (1952–1969).

https://en.m.wikipedia.org/wiki/J._Allen_Hynek 

PS:  io non sono mai stato testimone di alieni o di manifestazioni di entità aliene. Tuttavia, forse (qui sottolineo forse), potrei averne frequentata una per decenni. Mia madre era per me una incognita; beveva l'essenziale, non fumava, non dormiva, mangiava poco, non si ammalava, era sempre in energico movimento. Passati i novanta anni di età - grondante di sudore, dopo avere trascorso, giusto per passare il tempo, un paio di ore a stirare nel mezzogiorno della calura agostana riminese - qualche volta l'ho sentita pronunciare la frase: "andrò a coricarmi perchè mi sento un po' stanca". Quando lei entrava in una stanza io immaginavo che virus e batteri sarebbero fuggiti terrorizzati per cercare di evitare quello che di lì a poco sarebbe potuto succedere. Lei era impermeabile a qualsivoglia ideologia o argomentazione che non si traducesse in immediata modalità operativa. Quale (apparente) paradosso, per lei era anche normale individuare e ribaltare immediatamente i punti chiave in merito a qualsiasi argomento. Anche se non lo dava a vedere, era una persona sostanzialmente avversa a qualsivoglia autorità imposta. Ricordo bene che le uniche tesi che non aggrediva erano quelle che trattavano la musica blues, il jazz, il rock - forse perchè intuiva che tali approcci fossero per sè stessi fondamentalmente auto-ribaltanti - e la chimica che, anche quando poteva contenere aspetti meramente speculativi, fantasmatici, lei avrebbe potuto comunque scorgere qualche indispensabile componente operativa osservazionale- sperimentale. 

Per questa sua unicità, dall'età di dieci anni fino ai quindici, ho avuto il sospetto che lei potesse essere il prodotto di qualche ignoto esperimento alieno. 

A distanza di decenni penso che mia madre, sebbene da bambina le avessero imposto di conseguire la sola istruzione elementare - come peraltro molte della sua generazione, sarebbe stata (terrestre o aliena) un valido 'naturale' co-addestratore nel team di una scuola Shaolin.

keywords: UFO, UFOs, UAP, EBE ,

AATIP, UAPTF ,OVNI , virus,  magic string, aliens, esobio, exobiology

# pharma: drawing 'magic strings' for GPCRs

<< Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. >>

<< What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects? >> Ron O.  Dror. 

<< Dror's team describes discoveries that could be used to minimize or eliminate side effects in a broad class of drugs that target G protein-coupled receptors, or GPCRs. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of all prescription drugs, including antihistamines, beta blockers and opioids. So important is this molecular mechanism that Stanford professor Brian Kobilka shared the 2012 Nobel Prize in Chemistry for his role in discovering how GPCRs work. >>

Tom Abate. What if we could design powerful drugs without unwanted side effects? Stanford University.  May 19, 2020.

https://phys.org/news/2020-05-powerful-drugs-unwanted-side-effects.html    

The << work could provide a framework for the rational design of drugs that are more effective and have fewer side effects. >>

Carl-Mikael Suomivuori, Naomi R. Latorraca, et al. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science. 

Vol. 367, Issue 6480, pp. 881-887

doi: 10.1126/ science.aaz0326. Feb 21, 2020.

https://science.sciencemag.org/content/367/6480/881   

Also

keyword 'magic' in FonT

https://flashontrack.blogspot.com/search?q=magic

keyword 'GPCR'  in Wikipedia

https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor

# pharma: an ethno-drug revisited ... Ayahuasca, prelude of a "magic string" in neuropharmacology

To [AA] << knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. >>

Palhano-Fontes F, Barreto D, et al.  Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2018 Jun 15:1-9. doi: 10.1017/S0033291718001356.

https://www.ncbi.nlm.nih.gov/pubmed/29903051

<< Ayahuasca is a mixture of herbs, traditionally used for spiritual and therapeutic purposes. The main active ingredients are N,N-DMT, a potent psychedelic, and several molecules that inhibit the enzyme MAO. The MAO inhibitors serve to prevent the N,N-DMT from being broken down by the digestive system, allowing it to enter the bloodstream and cause hallucinations and other alterations of consciousness. >>

Ayahuasca, the Psychedelic Antidepressant? Neuroskeptic. June 17, 2018.

http://blogs.discovermagazine.com/neuroskeptic/2018/06/17/psychedelic-antidepressant-ayahuasca/

John Horgan. Yes, Make Psychedelics Legally Available, but Don't Forget the Risks. SciAm. July 6, 2018.

https://blogs.scientificamerican.com/cross-check/yes-make-psychedelics-legally-available-but-dont-forget-the-risks/

Also:

"magic string"

# pharma: waiting for new 'magic strings': psilocybin to treat depression. Oct 17, 2017.

https://flashontrack.blogspot.com/2017/10/pharma-waiting-for-new-strings.html

# s-brain: 70-years after; Dr. Albert revisited. Aug 22, 2016.

https://flashontrack.blogspot.com/2016/08/s-brain-70-years-after-dr-albert.html

# s-pharma-n-ethnomed: psilocybin. Dec 14, 2015.

https://flashontrack.blogspot.com/2015/12/s-pharma-n-ethnomed-psilocybin.html

# pharma: waiting for new 'magic strings': psilocybin to treat depression

AA << data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients [..] A ‘reset’ therapeutic mechanism is proposed >>

Robin L Carhart-Harris, Leor Roseman, et al. Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep  2017; 7 (13187) doi: 10.1038/s41598-017-13282-7

https://www.nature.com/articles/s41598-017-13282-7

<< Patients taking psilocybin to treat depression show reduced symptoms weeks after treatment following a 'reset' of their brain activity >>

Ryan O'Hare. Magic mushrooms may 'reset' the brains of depressed patients. Oct 13, 2017.

http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_12-10-2017-16-22-36

'Magic mushrooms' may 'reset' the brains of depressed patients, study suggests. Oct 13, 2017

https://www.sciencedaily.com/releases/2017/10/171013091018.htm

to update:

https://www.ncbi.nlm.nih.gov/pubmed/?term=psilocybin