# pharma: drawing 'magic strings' for GPCRs

<< Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. >>

<< What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects? >> Ron O.  Dror. 

<< Dror's team describes discoveries that could be used to minimize or eliminate side effects in a broad class of drugs that target G protein-coupled receptors, or GPCRs. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of all prescription drugs, including antihistamines, beta blockers and opioids. So important is this molecular mechanism that Stanford professor Brian Kobilka shared the 2012 Nobel Prize in Chemistry for his role in discovering how GPCRs work. >>

Tom Abate. What if we could design powerful drugs without unwanted side effects? Stanford University.  May 19, 2020.

https://phys.org/news/2020-05-powerful-drugs-unwanted-side-effects.html    

The << work could provide a framework for the rational design of drugs that are more effective and have fewer side effects. >>

Carl-Mikael Suomivuori, Naomi R. Latorraca, et al. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science. 

Vol. 367, Issue 6480, pp. 881-887

doi: 10.1126/ science.aaz0326. Feb 21, 2020.

https://science.sciencemag.org/content/367/6480/881   

Also

keyword 'magic' in FonT

https://flashontrack.blogspot.com/search?q=magic

keyword 'GPCR'  in Wikipedia

https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor

# gene: parental 'memory' could be inherited across generations (2); the happiness project.

<< In public talks and interviews, Mansuy (Isabelle Mansuy) says she's careful not to promise too much. As confident as she is in her mouse model, she says, there's lots more work to be done. "I don't think the field is moving too fast,"  Mansuy says. "I think it's moving too slow." >>

Andrew Curry. Parents’ emotional trauma may change their children’s biology. Studies in mice show how. Science. doi: 10.1126/science.aay7690. Jul. 18, 2019.    https://www.sciencemag.org/news/2019/07/parents-emotional-trauma-may-change-their-children-s-biology-studies-mice-show-how  

Andrew Curry. A painful legacy. Science. Vol. 365, Issue 6450, pp. 212-215. doi: 10.1126/science.365.6450.212. Jul 19, 2019.     https://science.sciencemag.org/content/365/6450/212

Jocelyn Kaiser. The Epigenetics Heretic. Science  Vol. 343, Issue 6169, pp. 361-363. doi: 10.1126/science.343.6169.361.  Jan 24, 2014.    https://science.sciencemag.org/content/343/6169/361   

David Grimm. The happiness project. Science. Vol. 359, Issue 6376, pp. 624-627. doi: 10.1126/science.359.6376.624. Feb 09, 2018.    https://science.sciencemag.org/content/359/6376/624  

Also

parental 'memory' could be inherited across generations. FonT. Jul 22, 2019.  http://flashontrack.blogspot.com/2019/07/gene-parental-could-be-inherited-across.html

'magic string'.  In: FonT.    https://flashontrack.blogspot.com/search?q=magic+string