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Visualizzazione post con etichetta opioids. Mostra tutti i post
Visualizzazione post con etichetta opioids. Mostra tutti i post

mercoledì 30 dicembre 2020

# behav: chaotic (jazz) music generated by songbirds during non-mating seasons for opioid reward

<< when songbirds sing during non-mating seasons, it's because singing releases an opioid naturally produced in their brain —that's right, a compound with the same biological makeup of the highly addictive painkillers. >> 

<< Animals—including birds, including humans—we produce our own endogenous opioids, and they reward behaviors naturally, like sexual behavior or feeding behavior, (..) Studies show that endogenous opioids also make play rewarding. Songbirds learn their songs, and must practice. When we listened to birds practicing in flocks, it almost sounded as if they were playing around with the notes. Darwin even suggested that birds in flocks may be singing for 'their own amusement.' So, we thought if singing is a playful behavior, it should involve opioids. >> Lauren Riters. 

<< in starlings, endogenous opioid-prompted song is evolutionarily advantageous, because singing in flocks allows them an opportunity to practice their song to prepare for the mating season. It might not be the most beautiful to listen to—Riters likened their chaotic song to freeform jazz—but that's okay. To them, it's just a warm-up for when they start looking for a mate. >> 

Songbirds sing, like humans flock, for opioid reward. University of Wisconsin-Madison. Oct 02, 2020. 


Stevenson, S.A., Piepenburg, A., et al. Endogenous opioids facilitate intrinsically-rewarded birdsong. Sci Rep 10, 11083. doi: 10.1038/ s41598-020-67684-1. Jul 6, 2020.




giovedì 21 maggio 2020

# pharma: drawing 'magic strings' for GPCRs

<< Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. >>

<< What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects? >> Ron O.  Dror. 

<< Dror's team describes discoveries that could be used to minimize or eliminate side effects in a broad class of drugs that target G protein-coupled receptors, or GPCRs. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of all prescription drugs, including antihistamines, beta blockers and opioids. So important is this molecular mechanism that Stanford professor Brian Kobilka shared the 2012 Nobel Prize in Chemistry for his role in discovering how GPCRs work. >>

Tom Abate. What if we could design powerful drugs without unwanted side effects? Stanford University.  May 19, 2020.


The << work could provide a framework for the rational design of drugs that are more effective and have fewer side effects. >>

Carl-Mikael Suomivuori, Naomi R. Latorraca, et al. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science. 
Vol. 367, Issue 6480, pp. 881-887
doi: 10.1126/ science.aaz0326. Feb 21, 2020.


Also

keyword 'magic' in FonT


keyword 'GPCR'  in Wikipedia