<< Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising results in clinical trials for the treatment of addiction, depression, and post-traumatic stress disorder. >>
AA << present the development of a modular biosynthetic production platform in the model microbe, Escherichia coli. (..) This is the highest psilocybin titer achieved to date from a recombinant organism and a significant step towards demonstrating the feasibility of industrial production of biologically-derived psilocybin. >>
Alexandra M.Adams, Nicholas A.Kaplan, et al. In vivo production of psilocybin in E. coli. Metabolic Engineering. Volume 56, pages 111-9. doi: 10.1016/j.ymben.2019.09.009. Sep 21, 2019.
https://www.sciencedirect.com/science/article/pii/S109671761930309X
Tanya Lewis. E. coli Could Produce a Popular Psychedelic for Therapeutic Use. Scientists engineered the bacterium to produce psilocybin. SCIAM. 322, 1, 16. Jan 2020.
https://www.scientificamerican.com/article/e-coli-could-produce-a-popular-psychedelic-for-therapeutic-use/
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