<< An interdisciplinary team of researchers (..) has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. Based on their research, the team said these viruses appear to cripple their own genome replication machinery. >>
<< Nonstructural Protein 3 - or NS3 - in flaviviruses, (..) cause a number of diseases in humans. NS3 is a key enzyme that these viruses use to copy their genomes. >>
<< Most vaccines are developed by finding random mutations that slow down virus growth, (..) By understanding how viral enzymes like NS3 work in great detail, we can use that information to rationally design new mutant viruses that replicate less well and act better as a vaccine, without having to rely on chance to make the vaccine. This can help develop vaccines more rapidly and precisely. >> Brian Geiss.
New details on how a viral protein puts the brakes on virus replication. Colorado State University. Feb 7, 2020.
https://m.phys.org/news/2020-02-viral-protein-virus-replication.html
Kelly E. Du Pont, Russell B. Davidson, et al. Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleft. The Journal of Biological Chemistry 295, 1551-1564. Feb 7, 2020.
http://m.jbc.org/content/295/6/1551
Also
keyword 'NS3 enzyme' in ncbi
https://www.ncbi.nlm.nih.gov/m/pubmed/?term=NS3+enzyme
