# behav: cry / not cry, babe ... POMC neurons modulate the crying behavior of pups (among mice)

<< Infants cry when separated from their mothers. Here, (AA) show that POMC (pro-opiomelanocortin) neurons in the arcuate nucleus of the hypothalamus—via ß-endorphin production and signaling—modulate the crying behavior of mouse pups. The effect of POMC neurons on vocal behavior depends on the expression of µ-opioid receptors, the main receptor for ß-endorphin. Thus, POMC neurons in the hypothalamus modulate infant cry through opioid signaling. >>️

Gabriela M. Bosque Ortiz, Marcelo O. Dietrich. POMC neurons modulate infant vocalizations through opioid signaling. bioRxiv 2022.08.15.504046. 

doi: 10.1101/ 2022.08.15.504046. Aug 15, 2022. 

https://www.biorxiv.org/content/10.1101/2022.08.15.504046v1

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Keywords: behav, brain, pnei, opioid signaling