<< Consider the yeti ... >>
Kathryn Schulz. Fantastic Beasts and How to Rank Them. The relative plausibility of impossible beings tells you a lot about how the mind works. Oct 30, 2017.
https://www.newyorker.com/magazine/2017/11/06/is-bigfoot-likelier-than-the-loch-ness-monster/
<< A Hug Before The Battle! These 2 large Malayan Water Monitor Lizards (Varanus Salvator) sizes each other up before the epic struggle for territory began. These lizards can grow up to 3m long >>
2017 National Geographic Nature Photographer of the Year.
<< Killing off cells that refuse to die on their own has proved a powerful anti-ageing strategy in mice. Now it's about to be tested in humans >>
<< Surprisingly, senescent cells turn out to be slightly different in each tissue. They secrete different cytokines, express different extracellular proteins and use different tactics to avoid death. That incredible variety has made it a challenge for labs to detect and visualize senescent cells >> Judith Campisi.
<< In young mice, no more than 1% of cells in any given organ were senescent. In two-year-old mice, however, up to 20% of cells were senescent in some organs. But there's a silver lining to these elusive twilight cells: they might be hard to find, but they're easy to kill >> Valery Krizhanovsky.
<< I think senolytics are drugs that could come soon and be effective in the elderly now, even in the next few years >> Nir Barzilai.
To stay young, kill zombie cells. Nature 2017; 550: 448 – 50. doi:10.1038/550448a Oct 26, 2017
https://www.nature.com/news/to-stay-young-kill-zombie-cells-1.22872
MozFest. The world's leading festival for the open Internet movement. Oct 27-29, 2017 Ravensbourne College, London
Decentralization. Who controls the Internet?
https://internethealthreport.org/v01/decentralization/
Building a better blockchain. A new generation of software developers are expanding the scope for an Internet powered by users.
https://internethealthreport.org/v01/stories/building-a-better-blockchain/
Giving artists control of their music.
https://internethealthreport.org/v01/stories/giving-artists-control-of-their-music/
<< Interbreeding between Neanderthals and early modern humans has been shown to have contributed about 2% Neanderthal DNA to the genomes of present-day non-Africans >>
AA << found two archaic haplotypes that contribute significantly to differences in sleep patterns >>
Archaic alleles near ASB1 and EXOC6 << are associated with a preference for being an "evening person" and an increased tendency for daytime napping and narcolepsy, respectively >>
Michael Dannemann, Janet Kelso. The Contribution of Neanderthals to Phenotypic Variation in Modern Humans. The American Journal of Human Genetics. 2017; 101 (4): 578 - 89. doi: 10.1016/j.ajhg.2017.09.010 Oct 5, 2017
http://www.cell.com/ajhg/fulltext/S0002-9297(17)30379-8
Darren Curnoe. Neanderthals didn't give us red hair but they certainly changed the way we sleep. Oct 6, 2017.
https://m.phys.org/news/2017-10-neanderthals-didnt-red-hair.html
DNA cracking machine
<< The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. The ability to efficiently convert target A•T base pairs to G•C could therefore advance the study and treatment of genetic diseases >>
AA << report adenine base editors (ABEs) that mediate conversion of A•T to G•C in genomic DNA >>
<< ABEs advance genome editing by enabling the direct, programmable introduction of all four transition mutations without double-stranded DNA cleavage >>
Nicole M. Gaudelli, Alexis C. Komor, et al. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature 2017 doi: 10.1038/nature24644 Oct 25, 2017
https://www.nature.com/nature/journal/vaap/ncurrent/full/nature24644.html
<< there are virtually no detectable byproducts such as random insertions, deletions, translocations, or other base-to-base conversions >>
Researchers extend power of gene editing by developing a new class of DNA base editors. Oct 25, 2017
https://m.phys.org/news/2017-10-enzyme-rewrites-genome.html
RNA cracking machine
<< RNA Editing for Programmable A to I Replacement (REPAIR), which has no strict sequence constraints, can be used to edit full-length transcripts containing pathogenic mutations >>
David B. T. Cox, Jonathan S. Gootenberg, et al. RNA editing with CRISPR-Cas13. Science. Oct 25, 2017:eaaq0180 doi: 10.1126/science.aaq0180
http://science.sciencemag.org/content/early/2017/10/24/science.aaq0180
Researchers engineer CRISPR to edit single RNA letters in human cells. Oct 25, 2017
https://m.phys.org/news/2017-10-crispr-rna-letters-human-cells.html
Lauran Neergaard. Scientists working toward reversible kind of gene editing. Oct. 25, 2017
https://m.phys.org/news/2017-10-scientists-reversible-kind-gene.html
also:
<< Exploded drawing of an archetypal ethoscope. The machine is composed of ... >>
<< The ethoscope could be customised for a range of different scenarios >>
<< Another possible use of ethoscopes is the adaptation of the platform to detect behavior of other animals >>
Studying insect behavior? Make yourself an ethoscope. Oct 19, 2017.
https://m.phys.org/news/2017-10-insect-behavior-ethoscope.html
Quentin Geissmann, Luis Garcia Rodriguez, et al. Ethoscopes: An open platform for high-throughput ethomics. PLOS Biol 15 (10): e2003026. doi: 10.1371/journal.pbio.2003026
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003026
