# gst: apropos how to manage misfolding (proteins)

<< Proteins are made up of chains of amino acids and during their formation they must fold to acquire an appropriate shape enabling them to perform their functions. However, when cells are subjected to stress or harm, such as high temperatures, some of the proteins may not fold properly. >>

<< There are three ways to solve the problem. The first option is to try to fix the folding in order to regain function, but this can be tricky because if stress conditions continue, the proteins continue unfolding. A second way is to destroy proteins that have not properly folded by way of machinery called proteasomes. But, in this study we reveal that the dominant route in yeast is a third option consisting of the formation of aggregates to protect misfolded proteins from degradation, >> Elena Hidalgo.

The strategy of cells to deal with the accumulation of misfolded proteins is identified. Universitat Pompeu Fabra. 

 Barcelona.  Feb 21, 2020.

https://m.phys.org/news/2020-02-strategy-cells-accumulation-misfolded-proteins.html

Margarita Cabrera, Susanna Boronat, et al. Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress. Cell Reports. Vol 30, Issue 7, P2430-2443.E4. Feb 18, 2020. 

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30102-9