# evol: flip of the script when an entity invert code sequences

<< Jekyll and Hyde flip of the script when bacteria invert gene sequences. If a cell can diversify its own genome, this can be advantageous in the face of changing environmental conditions. Bacteria have been found that can alter encoded proteins by using the trick of sequence inversion inside genes. >>️

Chia-Chi Chang, Robert R. Jenq. Jekyll and Hyde flip of the script when bacteria invert gene sequences. Nature 634, 42-43. Sep 25, 2024. 

https://www.nature.com/articles/d41586-024-02807-6

Chia-Chi Chang, Robert R. Jenq. Bacteria invert gene sequences to flip the script. Nature. Vol 634. Oct 3, 2024 (pdf)  https://media.nature.com/original/magazine-assets/d41586-024-02807-6/d41586-024-02807-6.pdf

Chanin RB, West PT, et al. Intragenic DNA inversions expand bacterial coding capacity. Nature. 2024 Oct; 634 (8032): 234-242. doi: 10.1038/s41586-024-07970-4. Sep 25, 2024. 

https://pubmed.ncbi.nlm.nih.gov/39322669/

Also: evolution,  in https://www.inkgmr.net/kwrds.html 

Also: 

DNA https://flashontrack.blogspot.com/search?q=dna 

RNA https://flashontrack.blogspot.com/search?q=rna 

CODES https://flashontrack.blogspot.com/search?q=codes

Also (quasi-stochastic poetry): 

DNA  https://inkpi.blogspot.com/search?q=dna 

RNA https://inkpi.blogspot.com/search?q=rna 

CODICE https://inkpi.blogspot.com/search?q=codice

Keywords: evolution, codes, DNA, RNA

# gst: apropos of 'normal' (jazzy?) codes, bacteria encode hidden, free-floating genes outside their genome.

AA << show that bacteria break that rule and can create free-floating and ephemeral genes, raising the possibility that similar genes exist outside of our own genome. >>️

<< What this discovery upends is the notion that the chromosome has the complete set of instructions that cells use to produce proteins, (..) We now know that, at least in bacteria, there can be other instructions not preserved in the genome that are nonetheless essential for cell survival. (..) The DNA molecule is a fully functioning, free-floating, transient gene. >> Samuel Sternberg. 

Bacteria Encode Hidden Genes Outside Their Genome—Do We? Columbia University Irving Medical Center. Aug 8, 2024. 

https://www.cuimc.columbia.edu/news/bacteria-encode-hidden-genes-outside-their-genome-do-we   

Stephen Tang, Valentin Conte, et al. De novo gene synthesis by an antiviral reverse transcriptase. Science. doi: 10.1126/ science.adq0876. Aug 8, 2024. 

https://www.science.org/doi/10.1126/science.adq0876

Also: 

codes https://flashontrack.blogspot.com/search?q=codes

DNA  https://flashontrack.blogspot.com/search?q=dna

RNA  https://flashontrack.blogspot.com/search?q=rna

CRISPR  https://flashontrack.blogspot.com/search?q=crispr

normal, jazz, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, codes, dna, rna, crispr, normal, jazz

# evol: the hypothesis of quasi-stochastic 'jazzy' metamechanics of biological evolution (in Arabidopsis thaliana)

<< Mutations occur when DNA is damaged and left unrepaired, creating a new variation. The scientists wanted to know if mutation was purely random or something deeper. What they found was unexpected. >>️

<< We always thought of mutation as basically random across the genome, (..) It turns out that mutation is very non-random and it's non-random in a way that benefits the plant. It's a totally new way of thinking about mutation. >> Grey Monroe. ️

Study challenges evolutionary theory that DNA mutations are random. UC Davis. Jan 12, 2022.

https://phys.org/news/2022-01-evolutionary-theory-dna-mutations-random.html

Monroe JG, Srikant T, et al. Mutation bias reflects natural selection in Arabidopsis thaliana. Nature. doi: 10.1038/ s41586-021-04269-6. Jan 12, 2022.

https://www.nature.com/articles/s41586-021-04269-6

FonT 

for a long time I have developed the suspicion that the small plant cared for by grandmother on the windowsill could be a not trivial image of (r)evolution ... 

The three ways of the plastoquinone inside the photosystem II complex. May 23, 2017.

https://flashontrack.blogspot.com/2017/05/s-phyto-three-ways-of-plastoquinone.html

Also

keyword 'evolution'  in FonT

https://flashontrack.blogspot.com/search?q=evolution

keyword 'evolution' | 'evoluzione'  in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=evolution

https://inkpi.blogspot.com/search?q=evoluzione

keyword 'jazz' in FonT

https://flashontrack.blogspot.com/search?q=jazz

keyword 'jazz' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=jazz

keywords: evol, dna, mutations, randomness, quasi-stochasticity, jazz

# gene: stuttering, syncopated (but not junk) codes

<< All organisms have DNA, the genetic material that provides a blueprint for life. The long double-helix-shaped DNA molecules in the body's cells are first translated into RNA molecules and then translated into proteins that ensure the functioning of the cell and the entire organism. But there are large parts of the DNA that are not used for making proteins. This is called 'junk DNA', because its function remained unclear for a long time. However, a certain type of junk DNA that is found in mosquitoes and which repeats itself dozens of times, known as 'satellite DNA', has now been shown to play an essential role in the early development of mosquito embryos. >>

Stuttering DNA orchestrates the start of the mosquito's life. Radboud University Medical Center. Apr 9, 2020.

https://www.sciencedaily.com/releases/2020/04/200409100332.htm 

AA << results reveal a mechanism by which satellite repeats regulate global gene expression in trans via piRNA-mediated gene silencing that is essential for embryonic development. >>

Rebecca Halbach, Pascal Miesen, et al. A satellite repeat-derived piRNA controls embryonic development of Aedes. Nature 580, 274–277. doi: 10.1038/s41586-020-2159-2. 

Apr 1, 2020.

https://www.nature.com/articles/s41586-020-2159-2

Also

keyword 'piRNA' in ncbi pubmed

"piRNA"[all] AND (Review[ptyp]) AND ("last 3 years"[PDat])

http://www.ncbi.nlm.nih.gov/pubmed

# gst: apropos of weak bonds, hydrophobic cohesion to stabilize the double helix of DNA

<< The main stabilizer of the DNA double helix is not the base-pair hydrogen bonds but coin-pile stacking of base pairs, whose hydrophobic cohesion, requiring abundant water, indirectly makes the DNA interior dry so that hydrogen bonds can exert full recognition power. (..) (AA) speculate that hydrophobic catalysis is a general phenomenon in DNA enzymes. >>

<< The forces that stabilize the DNA double helix are a prerequisite for the secure storage of genetic information but their modest strength is also necessary for the efficient processes of replication, transcription, recombination, and repair systems-wherein thermal fluctuations, or "breathing," play an important role >>

Bobo Feng, Robert P. Sosa, et al. Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects. PNAS.  116 (35) 17169-17174; Aug 27, 2019.  doi: 10.1073/ pnas.1909122116.    https://www.pnas.org/content/116/35/17169

DNA is held together by hydrophobic forces. Chalmers University of Technology. Sep 23, 2019.     https://m.phys.org/news/2019-09-dna-held-hydrophobic.html