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Visualizzazione post con etichetta avoidance. Mostra tutti i post
Visualizzazione post con etichetta avoidance. Mostra tutti i post

giovedì 16 maggio 2024

# gst: apropos of avoidance, packing of stiff rods on ellipsoids; the effects of self-avoidance

AA << study the effects of geometry and self-avoidance on the ordering of slender filaments inside nonisotropic containers, considering cortical microtubules in plant cells, and packing of genetic material inside viral capsids as concrete examples. >>

<< Within a mean-field approximation, (AA) show analytically how the shape of the container, together with self-avoidance, affects the ordering of the stiff rods. (They)  find that the strength of the self-avoiding interaction plays a significant role in the preferred packing orientation, leading to a first-order transition for oblate cells, where the preferred orientation changes from azimuthal, along the equator, to a polar one, when self-avoidance is strong enough. >>

<< While for prolate spheroids the ground state is always a polar-like order, strong self-avoidance results with a deep metastable state along the equator. >>

<< the critical behavior of this system is in fact related to the butterfly catastrophe model. >>

Doron Grossman, Eytan Katzav. Effects of self-avoidance on the packing of stiff rods on ellipsoids. Phys. Rev. E 109, 054111. May 9, 2024. 

Also: spheroids, self-assembly, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, ellipsoids, spheroids,  oblate- prolate spheroids, avoidance, self-avoidance


giovedì 1 febbraio 2024

# life: a new exception within the FDA Cures Act Informed Consent, the intriguing concept of 'Minimal Risk Clinical Investigations'.

<< The Food and Drug Administration (FDA, the Agency, or we) is issuing a final rule to amend its regulations to implement a provision of the 21st Century Cures Act (Cures Act). This final rule allows an exception from the requirement to obtain informed consent when a clinical investigation poses no more than minimal risk to the human subject and includes appropriate safeguards to protect the rights, safety, and welfare of human subjects. The final rule permits an institutional review board (IRB) to waive or alter certain informed consent elements or to waive the requirement to obtain informed consent, under limited conditions, for certain FDA-regulated minimal risk clinical investigations. >>️

Institutional Review Board Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations. A Rule by the Food and Drug Administration on 12/21/2023. federalregister.gov 

FonT:  'Minimal Risk Clinical Investigations (MRCI)': here are intriguing both (i) the scientific formalization of the operational methods decided (case by case) by the FDA about MRCI and (ii) the possible strategies - if at least one exists - for avoiding the 'multitude of unaware' from this type of interception.

Also: Are you ready for all this?, in https://www.inkgmr.net/kwrds.html

Also: evitare (avoid), in Notes (quasi-stochastic poetry)  https://inkpi.blogspot.com/search?q=evitare


Also: Robert F. Kennedy's opinion on the issue https://twitter.com/RobertKennedyJr/status/1752126207821271080  

Keywords: life, FDA, informed consent, risk, minimal risk, minimal risk clinical investigations, avoidance, 1or2achoos, are you ready