<< Collective cell dynamics play a crucial role in many developmental and physiological contexts. While two-dimensional (2D) cell migration has been widely studied, how three-dimensional (3D) geometry and topology interplay with collective cell behavior to determine dynamics and functions remains an open question. >>️
<< Using murine pancreas-derived organoids as a model system, (AA) find that epithelial spheres exhibit persistent rotation, rotational axis drift, and rotation arrest. Using a 3D vertex model, (they) demonstrate how the combined action of traction force and polarity alignment can account for these distinct rotational dynamics near a solid to flow transition. Furthermore, (their) analysis shows that the spherical tissue rotates as an active solid occasionally switching to a flowing state and exhibits spontaneous chiral symmetry breaking. >>️
Tzer Han Tan, Aboutaleb Amiri, et al. Emergent chirality in active solid rotation of pancreas spheres. PRX Life 2, 033006. Aug 8, 2024.
AA << say their work shows how symmetry-breaking processes in living active matter can be induced by the interplay of geometry, topology, and collective dynamics. >>️
Charles Day. Emergent Chirality in Active Rotation. Physics 17, s102. Aug 8, 2024.
Also: chiral, transition, in https://www.inkgmr.net/kwrds.html
Keywords: gst, transition, chiral, chiral symmetry breaking
