<< a developmental signaling pattern can be erased and replaced with a synthetic, patterned stimulus. (..) unlike pharmacological or genetic perturbations, light can be applied and removed quickly, focused with high spatial precision, or shaped into arbitrary spatial patterns. (AA) found that a simple all-or-none blue light stimulus, delivered to the embryonic termini, is sufficient to convert a lethal loss-of-function phenotype to rescue the full Drosophila life cycle: embryogenesis; larval development; pupation; adulthood; and fecundity. >>
<< Such optical control over development could be used to probe cell and tissue-level regulation, engineer tissue organization, and correct developmental defects. >>
Heath E. Johnson, Nareg J.V. Djabrayan, et al. Optogenetic Rescue of a Patterning Mutant. Current Biology. 30, 1-11. doi: 10.1016/ j.cub.2020.06.059. Jul 23, 2020.
Complex developmental patterns are under the control of surprisingly simple signals. Princeton University. Jul 23, 2020.
Also
keyword 'signal' in FonT
keyword 'signal' in Notes (quasi-stochastic poetry)
