# gst: emergent chirality in active rotation even with spontaneous chiral symmetry breaking.

<< Collective cell dynamics play a crucial role in many developmental and physiological contexts. While two-dimensional (2D) cell migration has been widely studied, how three-dimensional (3D) geometry and topology interplay with collective cell behavior to determine dynamics and functions remains an open question. >>️

<< Using murine pancreas-derived organoids as a model system, (AA) find that epithelial spheres exhibit persistent rotation, rotational axis drift, and rotation arrest. Using a 3D vertex model, (they) demonstrate how the combined action of traction force and polarity alignment can account for these distinct rotational dynamics near a solid to flow transition. Furthermore, (their) analysis shows that the spherical tissue rotates as an active solid occasionally switching to a flowing state and exhibits spontaneous chiral symmetry breaking. >>️

Tzer Han Tan, Aboutaleb Amiri, et al. Emergent chirality in active solid rotation of pancreas spheres. PRX Life 2, 033006. Aug 8, 2024.

https://journals.aps.org/prxlife/abstract/10.1103/PRXLife.2.033006

AA << say their work shows how symmetry-breaking processes in living active matter can be induced by the interplay of geometry, topology, and collective dynamics. >>️

Charles Day. Emergent Chirality in Active Rotation. Physics 17, s102. Aug 8, 2024. 

https://physics.aps.org/synopsis-for/10.1103/PRXLife.2.033006 

Also: chiral, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, transition, chiral, chiral symmetry breaking 

# brain: how the brain says 'Oops!'

AA << have uncovered how signals from a group of neurons in the brain's frontal lobe simultaneously give humans the flexibility to learn new tasks—and the focus to develop highly specific skills. >>

<< The study's key finding is that the brain uses the same group of neurons for performance feedback in many different situations—whether a person is attempting a new task for the first time or working to perfect a specific skill. >>

<< Part of the magic of the human brain is that it is so flexible, (..) We designed our study to decipher how the brain can generalize and specialize at the same time, both of which are critical for helping us pursue a goal. >> Ueli Rutishauser. ️

️

New Study Reveals How the Brain Says 'Oops!'. Cedars-Sinai Medical Center. May 5, 2022. 

https://www.cedars-sinai.org/newsroom/new-study-reveals-how-the-brain-says-oops/

AA << recorded the activity of more than 1000 neurons in the medial frontal cortex of human epilepsy patients while they performed complex cognitive tasks. They found that domain-general and domain-specific performance monitoring neurons were intermixed within this brain region. The population activity gave rise to a geometry that allowed domain-general signals to be read out with more than 90% accuracy on single trials while at the same time retaining the ability to separate different conflict conditions. These results show how the human medial frontal cortex resolves the fundamental trade-off between task generalization and specialization, which is critical for cognitive flexibility. >>

️

Zhongzheng Fu, Danielle Beam, et al. The geometry of domain-general performance monitoring in the human medial frontal cortex. Science. Vol 376, Issue 6593. doi: 10.1126/ science.abm9922. May 6, 2022.

https://www.science.org/doi/10.1126/science.abm9922

Also

keyword 'cervello' | 'brain' in Notes

(quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=cervello

https://inkpi.blogspot.com/search?q=brain

keyword 'brain' in FonT

https://flashontrack.blogspot.com/search?q=brain

keyword 'organoids' in FonT

https://flashontrack.blogspot.com/search?q=organoids

PS: An image of "oops", not completely spanned in the air, could be this:

Keywords: brain, mind, cervello, mente, oops

# ai.bot: a mechanism of analogy could be the master key to achieving an abstract artificial intelligence

<< It’s understanding the essence of a situation by mapping it to another situation that is already understood, (..) If you tell me a story and I say, ‘Oh, the same thing happened to me,’ literally the same thing did not happen to me that happened to you, but I can make a mapping that makes it seem very analogous. It’s something that we humans do all the time without even realizing we’re doing it. We’re swimming in this sea of analogies constantly. >> Melanie Mitchell.

️

John Pavlus. The Computer Scientist Training AI to Think With Analogies. QuantaMag. Jul 14, 2021.

https://www.quantamagazine.org/melanie-mitchell-trains-ai-to-think-with-analogies-20210714/

https://twitter.com/QuantaMagazine/status/1416798420669509635

Also

here a fuzzy example:  "qui non e' impossibile immaginare ..." (here it is not impossible to imagine ... )

in: Notes. Dec 31, 2015 (quasi-stochastic poetry)

https://flashontrack.blogspot.com/2015/12/rmx-s-gst-anomalous-formation-of.html

keyword 'gst' (general system theory) in FonT 

https://flashontrack.blogspot.com/search?q=gst

keyword 'organoids' in FonT

https://flashontrack.blogspot.com/search?q=organoids

keyword 'ai' | 'bot' in FonT

https://flashontrack.blogspot.com/search?q=ai

https://flashontrack.blogspot.com/search?q=bot

keyword 'ia' | 'ai' | 'robota' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=ia

https://inkpi.blogspot.com/search?q=ai

https://inkpi.blogspot.com/search?q=robota

# brain: the hypothesis that a brain organoid (a lab-grown brain) can reach consciousness.

<< In Alysson Muotri’s laboratory, hundreds of miniature human brains, the size of sesame seeds, float in Petri dishes, sparking with electrical activity. 

These tiny structures, known as brain organoids, are grown from human stem cells and have become a familiar fixture in many labs that study the properties of the brain. Muotri, a neuroscientist at the University of California, San Diego (UCSD), has found some unusual ways to deploy his. He has connected organoids to walking robots, modified their genomes with Neanderthal genes, launched them into orbit aboard the International Space Station, and used them as models to develop more human-like artificial-intelligence (AI) systems. (..) But one experiment has drawn more scrutiny than the others. In August 2019, Muotri’s group published a paper in Cell Stem Cell (*) reporting the creation of human brain organoids that produced coordinated waves of activity, resembling those seen in premature babies. The waves continued for months before the team shut the experiment down. This type of brain-wide, coordinated electrical activity is one of the properties of a conscious brain. >> 

Sara Reardon. Can lab-grown brains become conscious? Nature 586, 658-661. doi: 10.1038/ d41586-020-02986-y. Oct 27, 2020. Correction Nov 4, 2020.

https://www.nature.com/articles/d41586-020-02986-y     

(*)  Trujillo CA, Gao R, et al. Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development. Cell Stem Cell. 2019 Oct 3;25(4):558-569.e7. doi: 10.1016/ j.stem.2019.08.002. Aug 29, 2019. 

https://pubmed.ncbi.nlm.nih.gov/31474560/

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30337-6

# s-brain: growing mini human brains (3D midbrain-like organoids) ...

AA << developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers of neuronal cells expressing characteristic markers of human midbrain. >>

AA << detected electrically active and functionally mature mDA (midbrain dopaminergic) neurons and dopamine production in 3D midbrain-like organoids (MLOs). In contrast to human mDA neurons generated using 2D methods or MLOs generated from mouse embryonic stem cells, (AA) human MLOs produced neuromelanin-like granules that were structurally similar to those isolated from human substantia nigra tissues. >>

AA <<  MLOs bearing features of the human midbrain may provide a tractable in vitro system to study the human midbrain and its related diseases. >>

Junghyun Jo, Yixin Xiao, et al. Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell Stem Cell. Volume 19, Issue 2, p248–257, 4 August 2016. DOI: http://dx.doi.org/10.1016/j.stem.2016.07.005

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(16)30200-4

also:

https://www.sciencedaily.com/releases/2016/07/160730154504.htm

http://www.straitstimes.com/singapore/singapore-scientists-grow-mini-brains