# gst: apropos how to manage misfolding (proteins)

<< Proteins are made up of chains of amino acids and during their formation they must fold to acquire an appropriate shape enabling them to perform their functions. However, when cells are subjected to stress or harm, such as high temperatures, some of the proteins may not fold properly. >>

<< There are three ways to solve the problem. The first option is to try to fix the folding in order to regain function, but this can be tricky because if stress conditions continue, the proteins continue unfolding. A second way is to destroy proteins that have not properly folded by way of machinery called proteasomes. But, in this study we reveal that the dominant route in yeast is a third option consisting of the formation of aggregates to protect misfolded proteins from degradation, >> Elena Hidalgo.

The strategy of cells to deal with the accumulation of misfolded proteins is identified. Universitat Pompeu Fabra. 

 Barcelona.  Feb 21, 2020.

https://m.phys.org/news/2020-02-strategy-cells-accumulation-misfolded-proteins.html

Margarita Cabrera, Susanna Boronat, et al. Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress. Cell Reports. Vol 30, Issue 7, P2430-2443.E4. Feb 18, 2020. 

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30102-9

# gst: monkeyflower Mimulus code, with a simple spot generator inside

<< Many organisms exhibit visually striking spotted or striped pigmentation patterns. Developmental models predict that such spatial patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop interact. At its simplest, this self-organizing network only requires one self-activating activator that also activates a repressor, which inhibits the activator and diffuses to neighboring cells. >>

Baoqing Ding, Erin L. Patterson, et al. 

Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns. Current Biology.  Vol 30, Issue 5, P802-814.E8.  Mar 9, 2020.

https://www.cell.com/current-biology/fulltext/S0960-9822(19)31700-2

<< Patterns are everywhere in nature, not just color patterns but even how leaves are arranged on a stem, really anything with periodicity. Explaining these patterns could be similar in principle and that is what we're hoping to do, >> Yaowu Yuan

More clues for how the monkeyflower got its spots. University of Connecticut. Feb 20, 2020. 

https://m.phys.org/news/2020-02-clues-monkeyflower.html

# life: a funky, immediate approach of the sneezing from Wuhan (a relative safe barrier - this device is NOT a filter)

if (of course, if and only if) the problem is to save Western civilization from autocatalytic noise (and subsequent psychic, behavioral, political, economical, cultural catapulting collapse) caused by 1,2 sneezing of Wuhan, here a funky, immediate approach;

you have to get it: 

(1) thiny film (e.g. one piece of a thin film roll, made by polyethylene, used to wrap food);

(2) pocket cotton handkerchief  (like the ones used by cowboys, like those popping out of the pocket of the jackets that italian Prime Minister wears, perhaps wider);

(3) scotch tape (transparent adhesive tape);

below the assembly (1-3 minutes to compose it, two or 'n' times a day); 

This device is relatively safe even if your interlocutor spits in your mouth (in that  case, to protect the eyes you remember that you also need protective glasses and any earplugs, disposable gloves ...);

you can get more security by spraying - on the outside of the handkerchief - a mixture of alcohol, hydrogen peroxide (H2O2) and distilled water (the composition indicated by the WHO,  without glycerol);  cfr Guide to Local Production:  WHO-recommended Handrub Formulations  (reagents for formulation 1) Revised April 2010  

https://www.who.int/infection-prevention/tools/hand-hygiene/handrub-formulations/en

doc.pdf

https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf

With this device you can travel around the city, on buses, on trains, ... in relative safety, yours and your neighbors; 

instead of film roll for food you could use a waterproofing spray but the cost is high and the chemical one is probably toxic for human

Also

keyword 'virus' in FonT

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi- stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

keyword 'snake' in FonT

https://flashontrack.blogspot.com/search?q=snake

keyword 'bat' in FonT

https://flashontrack.blogspot.com/search?q=bat

# gst: global dust storms from waves in thin air.

<< Mars has a very thin atmosphere, with nearly one hundredth the density of ours on Earth, and gravity pulls with little more than one third of the strength we feel on our planet. As a result, dust storms can go global. >>

Waves in thin air with broad effects. Instituto de Astrofísica e Ciencias do Espaco. Mar 17, 2020.

https://m.phys.org/news/2020-03-thin-air-broad-effects.html

G.Gilli,  F.Forget, et al. Impact of Gravity Waves on the Middle Atmosphere of Mars: A Non‐Orographic Gravity Wave Parameterization Based on Global Climate Modeling and MCS Observations. Journal of Geophysical Research: Planets. Volume 125, Issue 3.  doi: 10.1029/2018JE005873. Feb 7, 2020.

https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/2018JE005873

# life: Snake Plissken movies revisited, the chaotic escape from Milan, Paris, ...

 "Call me Snake",  the furious chaotic escape of probably conscious "guests",  'cause of 1,2 initial long-range Wuhan sneezing.

<< Everyone we know in Paris who was able to leave the city have done so. >>  

Henry Samuel. Parisian mother on 

escaping the coronavirus lockdown.  Mar 17, 2020

https://www.telegraph.co.uk/news/2020/03/17/dont-know-would-have-done-parisian-mother-escaping-coronavirus/

Also 

"Call me Snake", by Snake Plissken

https://en.m.wikipedia.org/wiki/Snake_Plissken

Also

keyword 'snake' in FonT

https://flashontrack.blogspot.com/search?q=snake

keyword 'snake' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=snake

# life: apropos of "herd immunity" ... ,

Apropos of  "herd immunities" ..., 

here a subtle, bizarre convergence with a specific traditional medical behavior, clearly annotaded in the field of ethnomedicine: the "saliva healers"

keyword "saliva" in Notes  (quasistochastic-poetry)

https://inkpi.blogspot.com/search?q=saliva

keyword "saliva" in FonT

https://flashontrack.blogspot.com/search?q=saliva

keyword "herd | flock immunity" in NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/?term=%22Herd+immunity%22

https://www.ncbi.nlm.nih.gov/m/pubmed/30273325/?i=2&from=%22flock%20immunity%22

Also:  "pruneto di sputo" in  "aqa (any question answered)". May 21, 2005

(quasistochastic-poetry)

https://inkpi.blogspot.com/2005/05/1781-aqa-any-question-answered.html

Also: "dall'orli frangiati di sopratoniche".   in "a pain-suppressive effect".  Nov 14, 2006. (quasistochastic-poetry).

https://inkpi.blogspot.com/2006/11/2086-pain-suppressive-effect.html

# gst: apropos of 'reprogrammed by a virus' (2), the case of 'virocells'

<< If it looks like a duck and quacks like a duck, so the adage goes, it must be a duck. But if the duck gets infected by a virus so that it no longer looks or quacks like one, is it still a duck? >>

Viruses reprogram cells into different virocells. DOE/Joint Genome Institute. 

 Feb 11, 2020.

https://m.phys.org/news/2020-02-viruses-reprogram-cells-virocells.html

<< Ocean viruses are abundant and infect 20–40% of surface microbes. Infected cells, termed virocells, are thus a predominant microbial state. Yet, virocells and their ecosystem impacts are understudied, thus precluding their incorporation into ecosystem models. >>

AA << investigated how unrelated bacterial viruses (phages) reprogram one host into contrasting virocells with different potential ecosystem footprints. >>

<< Ecologically, this work suggests that one cell, infected versus uninfected, can have immensely different metabolisms that affect the ecosystem differently. >>

Howard-Varona C, Lindback MM, et al. Phage-specific metabolic reprogramming of virocells. ISME J. doi: 10.1038/s41396-019-0580-z. Jan 2, 2020.

https://www.nature.com/articles/s41396-019-0580-z

Also

keyword 'virus' in FonT

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi- stochastic poetry)

https://inkpi.blogspot.com/search?q=virus