# life: apropos of saliva healers, herd immunity revisited and now hypothetically approachable even within NIH

<< President-elect Donald Trump is tapping Dr. Jay Bhattacharya, a Stanford University health researcher, to be the next director of the National Institutes of Health (NIH). >>

️

<< Bhattacharya was one of three authors of the document (#1). The declaration called for speeding herd immunity by allowing people at low risk to get infected while protecting those most vulnerable, like the elderly. >>

Rob Stein. Trump turns to critic of COVID mandates to run NIH. npr.org. 

Nov 26, 2024. 

https://www.npr.org/sections/shots-health-news/2024/11/26/nx-s1-5195168/nih-bhattacharya-trump-election-2024

<< The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk. We call this Focused Protection. >>

️

(#1) - Martin Kulldorff, Sunetra Gupta, Jay Bhattacharya. Great Barrington Declaration. Oct 4, 2020. https://gbdeclaration.org/

FonT

From my point of view 'herd immunity'  can be engineered if and only if, even in the case of sars-covid-19 or flu, simultaneous protection is used with an effective, easy available, antiviral drug.

In this regard, a non-compassionate but logical easy approach could be the indirect inhalation of alcohol ~70% already at the first signs of rhinorrhea, as follows:

(-) start self-treatment (spray plus cotton mask):

Mar 20, 2020  https://flashontrack.blogspot.com/2020/03/life-funky-immediate-approach-of.html  

(-) outcomes

Jul 13, 2022  https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html  

Oct 4, 2023 https://flashontrack.blogspot.com/2023/10/life-proposito-di-1or2achoos-da-wuhan.html  

Ultimately, here it could hypothesize a case of historic, singular checkmate of 'one against all'. Anzicheforse?

Also: drop, saliva, sars* covid* (aka 1or2achoos), virus, ethno, Mr. Donald, POTUS, tit-for-tat, game, in https://www.inkgmr.net/kwrds.html 

Keywords: life, drop, saliva, saliva healers, herd immunity, sars, mers, 2019ncov, sarscov2, covid19, coronavirus, 1or2achoos, virus, ethno, ethnomedicine, Donald, POTUS, tit-for-tat, game

PS: I couldn't say why, but in certain contexts, the incipit of an answer that the physicist Enrico Fermi https://it.m.wikipedia.org/wiki/Enrico_Fermi  gave to a journalist always comes back to my mind: 'the physics that is done in our laboratory ...' . 

An example of exceptional, clear, even poetic analysis and synthesis skills (in only 8 words).

# life: simnotrelvir, a Chinese pill anti covid-19

<< A drug called simnotrelvir speeds up recovery from mild to moderate COVID-19 by about 1.5 days, relieving symptoms such as fever, cough and runny nose.  >>

<< Whether it can help people who are at high risk of hospitalization and death from COVID-19 is still unclear. >>️️

Saima Sidik. Potent new pill provides COVID relief for the masses. Nature. doi: 10.1038/d41586-024-00117-5. Jan 17,  2024. 

https://www.nature.com/articles/d41586-024-00117-5

Bin Cao, Yeming Wang, et al. Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. N Engl J Med 2024; 390:230-241. doi: 10.1056/NEJMoa2301425. Jan 18, 2024.

https://www.nejm.org/doi/10.1056/NEJMoa2301425

FonT: if it is (another) 'pastroky', you can redirect yourself towards an alcohol plus peroxide solution... just to put the classic patch on it. 

Also:  a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia. FonT. Oct 4, 2023. 

https://flashontrack.blogspot.com/2023/10/life-proposito-di-1or2achoos-da-wuhan.html

Also: 1or2achoos, sars, covid, virus, pastroky, in:   https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life: a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia

a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia di inizio dei 6 flu|covid che ho contratto dal gen2020 ad oggi con i relativi tempi di 'smorzamento' dell'infezione, trattati nebulizzando una miscela di alcool e H2O2 ( https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html )

(1) 2020.04.11-16:04 ~12h (non vaccinato)

(2) 2021.09.01-07:40 ~12h (non vaccinato)

(3) 2022.06.11-08:26 18-36h (+1mese post vaccino, 3dosi)

(4) 2022.12.24-07:52 ~24h 

(5) 2023.02.28-12:09 ~24h 

(6) 2023.04.08-09:32 24-36h 

I tempi necessari per 'spegnere' questi  flu|covid sono tutti notevolmente inferiori (~80%) rispetto alle pregresse forme di flu che ho contratto delle quali ho memoria.

Invece non ho altre parole da aggiungere per commentare i diversi argomenti associabili a '1or2achoos' dal febbraio 2020 ad oggi.

Potrei (e.g. expectedepidemic, lockdown, greenpass, indicatori, statistiche, accademieacucciabili, sadichepredazioni, bucodibilancio, pastroky, ...) nelle bizzarre forme della poetica quasistocastica ( https://inkpi.blogspot.com/ ), ma mi astengo.

Anche: "Ricordo che quando si era ragazzi". in: "il pino di takata matsubara". Notes. Apr 1, 2011. https://inkpi.blogspot.com/2011/04/2157-il-pino-di-takata-matsubara.html

Anche: "e Da-Li' si sparse pell'aere". in: "cracker tendenziali". Notes. Apr 4, 2008. https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

Anche: "in attesa del beffardo tsunami". in: "onda di carambola". Notes. Nov 29, 2004. 

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

Anche: "aproposito di '1or2achoos' (da Wuhan (?)) ...". FonT. Jul 13, 2022. https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Anche: 1or2achoos, sars, covid, virus, pastroky, in: 

https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life; the hypothesis of early treatment (at home) of the virus sars-cov-2

Figure 1 - Proposed maladaptive hyperinflammatory response to SARS-CoV-2 infection (Perico N, Cortinovis M, Suter F, Remuzzi G. (2022))

<< A few observational studies have tested NSAIDs [non-steroidal anti-inflammatory drugs] (especially  relatively selective COX-2 inhibitors), often as part of multipharmacological protocols, for early outpatient treatment of COVID-19. The findings from these studies are promising and point to a crucial role of NSAIDs for the at-home management of people with initial COVID-19 symptoms. >>

<< Celecoxib, ibuprofen, and nimesulide should be avoided in children younger than 12 years, whereas aspirin should be taken only under prescription and at the dose recommended by the family doctor. >>️

️

Norberto Perico, Monica Cortinovis, Fredy Suter, Giuseppe Remuzzi. Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents. The Lancet Infectious Diseases. doi: 10.1016/ S1473-3099(22)00433-9. Aug 25, 2022. 

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00433-9/fulltext

FonT

therefore the deadly infection by sars-cov-2 that has generated so much suffering,  pain, and dead everywhere it is recently hypothesized that it could easily be treated at home (an early treatment) with some success.

Also

keywords 'covid-19' and 'NSAIDs' in PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=covid-19+NSAIDs&filter=datesearch.y_1

Also

aproposito di '1or2achoos' (da Wuhan (?)) ... FonT. Jul 13  2022.

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Keywords: virus, coronavirus,  sarscov2, 2019ncov, covid19, 1or2achoos

# life: aproposito di '1or2achoos' (da Wuhan (?)) ...

a proposito di '1or2achoos' (da Wuhan (?)) ... cfr Weekly epidemiological update on COVID-19 - 6 July 2022. Edition 99. Emergency Situational Updates. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---6-july-2022   img   https://cdn.who.int/media/images/default-source/mca/mca-covid-19/coronavirus-2.tmb-768v.jpg?sfvrsn=4dba955c_12 

Qui l'approccio semplice, diretto, efficace che ho usato per la prevenzione ed eventuale gestione personale dell'entità coronavirus /  SARS-COV-2 (SARS: Severe Acute Respiratory Syndrome ) 

In data 20 Marzo 2020 ho pubblicato sul mio blog FonT - e, giusto per intendersi, ho contemporaneamente inviato il testo a una mia mail criptata - un approccio nell'ipotesi di disattivare / spegnere il coronavirus (sars-cov-2) che causa covid-19;   

Qui il link   ('you can get more security by spraying...)'   https://flashontrack.blogspot.com/2020/03/life-funky-immediate-approach-of.html

L'approccio pubblicato consisteva nell'uso di una soluzione di alcool (uso alimentare, 96%), perossido di idrogeno (3%) e acqua da nebulizzare con un generico dosatore spray tascabile (usato per nebulizzare profumi); 

La stechiometria di due dei tre componenti (alcool e perossido di idrogeno) era indicata sul sito del WHO (e consigliata per disinfettare superfici);

Qui il link attuale del doc 

12 WHO-recommended handrub formulations (2009) - Formulation I      

https://www.ncbi.nlm.nih.gov/books/NBK144054  che a quel tempo era presente, e attualmente assente, sul sito WHO al link 

https://www.who.int/infection-prevention/tools/hand-hygiene/handrub-formulations/en  

e scaricabile nella forma di doc.pdf

https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf  

Modificai la soluzione con la sostituzione di glicerolo con acqua per consentire la nebulizzazione del prodotto; 

Da allora ho sempre usato la miscela spray per disinfettare mani e mascherine di cotone (doppia mascherina, di cotone, riusabile, in posizione esterna e quando disponibile ffp2 in posizione interna); 

Tuttavia ho usato la stessa miscela per trattare i tre 'flu' (ipoteticamente covid-19) che ho contratto nei tre anni 2020, 2021 e 2022.  

In particolare, tutte le volte che ho avuto necessità di soffiare il naso (per secrezione mucosa, causa rinorrea) ho successivamente trattato entrambi naso e gola con la miscela spray; direttamente sulla mucosa orale e indirettamente nella mucosa nasale inspirando la soluzione preventivamente nebulizzata sul dorso della mano;

Nei primi due casi (2020 e 2021) ho spento il 'flu' in mezza giornata (in entrambe le situazioni non ero vaccinato); nel terzo caso ho spento il 'flu' in 2 giorni scarsi di trattamento (ero già stato vaccinato con le 2+1 dosi perchè obbligatorie in Italia specialmente per chi era iscritto all'Ordine dei Biologi e comunque per chi aveva raggiunto l'età di 50+ anni  

( OMS - Piano vaccini anti Covid-19

https://www.salute.gov.it/ )

I flu precedenti al 2020 (circa 60 flu nell'arco di 70 anni di età, a ciclicità annuale) mi avevano sempre impegnato in circa tre giorni di pre- crisi, tre giorni di crisi a letto e tre giorni di post- crisi (convalescenza) per un totale di mai meno di quattro-cinque giorni di parziale compromissione dell'autonomia; 

Nelle mie tre individuali esperienze, confrontate con tutte le pregresse, l'immunità sembra essere stata quasi immediata, senza alcuna compromissione dell'autonomia.

Se (beninteso, se e solo se) le future risposte individuali del mio sistema immunitario alle future probabili ondate epidemiche da flu opp sars saranno equivalenti alle tre citate sopra, per quello che mi riguarda questa problematica si è chiusa a far data dal 20 marzo 2020, indipendentemente dalle future disponibilità di vaccini anti-flu anti-sars. 

Qui l'ipotetico meccanismo di azione.

I coronavirus (come i virus flu a causa di orthomyxoviridae) si duplicano nelle mucose orale e nasale; il capside virale ( e.g. Chung-ke Chang et al. Antiviral Res. 2014 Mar. https://pubmed.ncbi.nlm.nih.gov/24418573/ ) in presenza di alcool probabilmente si apre per denaturazione proteica e questo consente a un sistema immunitario fisiologicamente attivo di leggere sia il capside (che dovrebbe comunque conservare la struttura primaria) sia parti della sua metameccanica molecolare interna; 

Anche

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes 

(quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

Keywords: virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

PS: certo è che i colleghi biomedici (qualunque cosa si intenda per  'colleghi' ), con l'epifanie SARS (Nov 2002, Guangdong, China; MERS,  Nov 2012, Gedda, Saudi Arabia, SARS-COV-2, 2019-2020, Wuhan, China) non sembra abbiano mostrato il consueto brillamento delle proprie loro medesime - senz'alcun dubbio elevatissime - potenzialità.  Per modo di dire ed anzicheforse ... Forse, talvolta, si tende a sottovalutare la lezione del Maestro, indimenticato, indimenticabile Jelly Roll:  "Amico, qualunque cosa suonerai ..."   https://flashontrack.blogspot.com/search?q=jelly+roll

# life: a weird revisited from ethnomedicine inside an approach in epidemiology, the 'saliva healers' vs. 'herd immunity'.

(A) 

<< chiamati 'dottori della saliva' >>

️

A pain-suppressive effect. Notes (quasi-stochastic poetry). Nov 14, 2006.    

https://inkpi.blogspot.com/2006/11/2086-pain-suppressive-effect.html

(B) 

Apropos of "herd immunity" ... FonT. Mar 16, 2020. 

https://flashontrack.blogspot.com/2020/03/life-apropos-of-herd-immunity.html

(C) 

<< During 2020, most schools were never pro-actively closed to hinder virus spreading (with compulsory physical attendance required by law in Sweden and no option for distance or home learning)  >> 

<< Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives. >>️

<< The Swedish Strategy was also influential abroad, and became an argument in other countries including, among others, the United States (US), United Kingdom (UK) and Australia, to loosen restrictions >>️ 

<< Supporters of the natural herd-immunity strategy promoted a widespread “controlled” spread in society, to obtain herd-immunity without vaccination >>️ 

<< Email conversations and statements from the State Epidemiologist and others show that they at least speculated on the use of children to acquire herd-immunity, while at the same time publicly claiming children played a negligible role in transmission and did not become ill >> 

<< During 2020, however, Sweden had ten times higher COVID-19 death rates compared with neighbouring Norway. >>️️

️

Nele Brusselaers, David Steadson, et al. Evaluation of science advice during the COVID-19 pandemic in Sweden. Humanit Soc Sci Commun 9, 91. doi: 10.1057/ s41599-022-01097-5. Mar 22, 2022.  

https://www.nature.com/articles/s41599-022-01097-5

Also

keyword 'saliva' in Notes  (quasi-stochastic poetry)   

https://inkpi.blogspot.com/search?q=saliva

keyword 'saliva' in FonT   

https://flashontrack.blogspot.com/search?q=saliva

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT   

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

Also

(here a homemade mask with a pre  antiviral spray mixture)

A funky, immediate approach of the sneezing from Wuhan (a relative safe barrier - this device is NOT a filter). FonT. Mar 20, 2020. 

https://flashontrack.blogspot.com/2020/03/life-funky-immediate-approach-of.html

keywords: ethnomedicine, saliva, saliva healers, herd immunity, virus, coronavirus, sars, mers, 2019ncov, sarscov2, covid19, 1or2achoos 

# life: apropos of fuzzy cooperation, Ralph fuzzy mixture vs. world fuzzy dance ...

<< In 2013, the American virologist Ralph Baric approached Zhengli Shi at a meeting. Baric was a top expert in coronaviruses, with hundreds of papers to his credit, and Shi, along with her team at the Wuhan Institute of Virology, had been discovering them by the fistful in bat caves. In one sample of bat guano, Shi had detected the genome of a new virus, called SHC014, that was one of the two closest relatives to the original SARS virus, but her team had not been able to culture it in the lab. >>️

<< Baric had developed a way around that problem—a technique for “reverse genetics” in coronaviruses. Not only did it allow him to bring an actual virus to life from its genetic code, but he could mix and match parts of multiple viruses. He wanted to take the “spike” gene from SHC014 and move it into a genetic copy of the SARS virus he already had in his lab. The spike molecule is what lets a coronavirus open a cell and get inside it. The resulting chimera would demonstrate whether the spike of SHC014 would attach to human cells. >>️

<< Just as when you trade in part of a poker hand for fresh cards, there was no way of knowing whether the final chimeras would be stronger or weaker. >>

<< If you study a hundred different bat viruses, your luck may run out. >> Ralph Baric. 

<< In 2014, the NIH awarded a five-year, $3.75 million grant to EcoHealth Alliance to study the risk that more bat-borne coronaviruses would emerge in China, using the same kind of techniques Baric had pioneered. Some of that work was to be subcontracted to the Wuhan Institute of Virology. >>

<< Consider this hypothetical scenario, (..) An important gain-of-function experiment involving a virus with serious pandemic potential is performed in a well-regulated, world-class laboratory by experienced investigators, but the information from the experiment is then used by another scientist who does not have the same training and facilities and is not subject to the same regulations. In an unlikely but conceivable turn of events, what if that scientist becomes infected with the virus, which leads to an outbreak and ultimately triggers a pandemic >>  Anthony Fauci (director of the NIH’s National Institute of Allergy and Infectious Diseases) (2012).

️

<< Paul’s grilling of Fauci brought new scrutiny to the relationship between Ralph Baric’s lab at UNC and Zhengli Shi’s at WIV, with some narratives painting Baric as the Sith master of SARS and Shi as his ascendant apprentice. They did share resources—for example, Baric sent the transgenic mice with human lung receptors to Wuhan.  >>

️

<< During a hearing on May 11, 2021, Senator Rand Paul confronted Anthony Fauci over funding of bat-virus research by the National Institutes of Health. >>️

<< The NIH has still not fully explained its decision-making and did not reply to questions. Citing a pending investigation, it has declined to release copies of the grant that sent the Wuhan institute about $600,000 between 2014 and 2019. It has also revealed little about its new system for assessing gain-of-function risks, which is carried out by an anonymous review panel whose deliberations are not made public. >>️

️

Rowan Jacobsen. Inside the risky bat-virus engineering that links America to Wuhan. China emulated US techniques to construct novel coronaviruses in unsafe conditions. MIT TechRev. Jun 29, 2021. 

https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan

Also

<< " ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 4, 2008. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

<< in attesa del beffardo tsunami. >> in: 1619 - onda di carambola. Notes. Nov 29, 2004. (quasi-stochastic poetry).

️

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

keyword 'virus' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

keyword 'virus' in FonT 

https://flashontrack.blogspot.com/search?q=virus

keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=caos

https://inkpi.blogspot.com/search?q=caotico

FonT

no surprise, no amazement here, I know chickens behaviors. 

<< Ricordo che quando si era ragazzi, negli anni sessanta, ... >> in: 2157 - il pino di takata matsubara. Apr 1, 2011. Notes. 

https://inkpi.blogspot.com/2011/04/2157-il-pino-di-takata-matsubara.html

# life: they ( NIH, Ralph Baric’s Univ.of North Carolina lab, Wuhan Instit.of Virology ) never created a supervirus, anzicheforse ...

<< 

In May, the coronavirus researcher Ralph Baric found himself at the center of the debate over gain-of-function research ( https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan ), in which scientists engineer new properties into existing viruses. And during a congressional hearing, Senator Rand Paul implied that the National Institutes of Health had been funding such research at both the Wuhan Institute of Virology and Baric’s University of North Carolina lab, and that the two labs had been collaborating to make “superviruses”. Baric released a statement clarifying the research in question did not qualify as gain-of-function, and none of the SARS-like coronaviruses he’d used in the experiments were closely related to SARS-CoV-2, yet that did little to quell questions about the role his research may have played in furthering scientists’ ability to modify coronaviruses in potentially dangerous ways. Baric believes such research is essential to the development of vaccines and other countermeasures against emerging viruses, a project he has been engaged in for more than 20 years. His research laid the groundwork for the first approved anti-covid drug and helped speed the development of the mRNA vaccines that have proved so pivotal. 

MIT Technology Review recently asked Baric to explain what constitutes a gain-of-function experiment, why such research exists, and whether it could have played any role in the pandemic. Read the full interview. ( https://www.technologyreview.com/2021/07/26/1030043/gain-of-function-research-coronavirus-ralph-baric-vaccines )

>>️

Rowan Jacobsen. Why researchers need to tinker with viruses. The Download from MIT Technology Review newsletters@technologyreview.com  

The Download from MIT (mail). Jun 26, 2021 14:12

Also

<< ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 04, 2008. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

keyword 'virus' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

keyword 'virus' in FonT 

https://flashontrack.blogspot.com/search?q=virus

# life: apropos of "herd immunity" ... ,

Apropos of  "herd immunities" ..., 

here a subtle, bizarre convergence with a specific traditional medical behavior, clearly annotaded in the field of ethnomedicine: the "saliva healers"

keyword "saliva" in Notes  (quasistochastic-poetry)

https://inkpi.blogspot.com/search?q=saliva

keyword "saliva" in FonT

https://flashontrack.blogspot.com/search?q=saliva

keyword "herd | flock immunity" in NCBI

https://www.ncbi.nlm.nih.gov/m/pubmed/?term=%22Herd+immunity%22

https://www.ncbi.nlm.nih.gov/m/pubmed/30273325/?i=2&from=%22flock%20immunity%22

Also:  "pruneto di sputo" in  "aqa (any question answered)". May 21, 2005

(quasistochastic-poetry)

https://inkpi.blogspot.com/2005/05/1781-aqa-any-question-answered.html

Also: "dall'orli frangiati di sopratoniche".   in "a pain-suppressive effect".  Nov 14, 2006. (quasistochastic-poetry).

https://inkpi.blogspot.com/2006/11/2086-pain-suppressive-effect.html