# life: aproposito di '1or2achoos' (da Wuhan (?)) ...

a proposito di '1or2achoos' (da Wuhan (?)) ... cfr Weekly epidemiological update on COVID-19 - 6 July 2022. Edition 99. Emergency Situational Updates. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---6-july-2022   img   https://cdn.who.int/media/images/default-source/mca/mca-covid-19/coronavirus-2.tmb-768v.jpg?sfvrsn=4dba955c_12 

Qui l'approccio semplice, diretto, efficace che ho usato per la prevenzione ed eventuale gestione personale dell'entità coronavirus /  SARS-COV-2 (SARS: Severe Acute Respiratory Syndrome ) 

In data 20 Marzo 2020 ho pubblicato sul mio blog FonT - e, giusto per intendersi, ho contemporaneamente inviato il testo a una mia mail criptata - un approccio nell'ipotesi di disattivare / spegnere il coronavirus (sars-cov-2) che causa covid-19;   

Qui il link   ('you can get more security by spraying...)'   https://flashontrack.blogspot.com/2020/03/life-funky-immediate-approach-of.html

L'approccio pubblicato consisteva nell'uso di una soluzione di alcool (uso alimentare, 96%), perossido di idrogeno (3%) e acqua da nebulizzare con un generico dosatore spray tascabile (usato per nebulizzare profumi); 

La stechiometria di due dei tre componenti (alcool e perossido di idrogeno) era indicata sul sito del WHO (e consigliata per disinfettare superfici);

Qui il link attuale del doc 

12 WHO-recommended handrub formulations (2009) - Formulation I      

https://www.ncbi.nlm.nih.gov/books/NBK144054  che a quel tempo era presente, e attualmente assente, sul sito WHO al link 

https://www.who.int/infection-prevention/tools/hand-hygiene/handrub-formulations/en  

e scaricabile nella forma di doc.pdf

https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf  

Modificai la soluzione con la sostituzione di glicerolo con acqua per consentire la nebulizzazione del prodotto; 

Da allora ho sempre usato la miscela spray per disinfettare mani e mascherine di cotone (doppia mascherina, di cotone, riusabile, in posizione esterna e quando disponibile ffp2 in posizione interna); 

Tuttavia ho usato la stessa miscela per trattare i tre 'flu' (ipoteticamente covid-19) che ho contratto nei tre anni 2020, 2021 e 2022.  

In particolare, tutte le volte che ho avuto necessità di soffiare il naso (per secrezione mucosa, causa rinorrea) ho successivamente trattato entrambi naso e gola con la miscela spray; direttamente sulla mucosa orale e indirettamente nella mucosa nasale inspirando la soluzione preventivamente nebulizzata sul dorso della mano;

Nei primi due casi (2020 e 2021) ho spento il 'flu' in mezza giornata (in entrambe le situazioni non ero vaccinato); nel terzo caso ho spento il 'flu' in 2 giorni scarsi di trattamento (ero già stato vaccinato con le 2+1 dosi perchè obbligatorie in Italia specialmente per chi era iscritto all'Ordine dei Biologi e comunque per chi aveva raggiunto l'età di 50+ anni  

( OMS - Piano vaccini anti Covid-19

https://www.salute.gov.it/ )

I flu precedenti al 2020 (circa 60 flu nell'arco di 70 anni di età, a ciclicità annuale) mi avevano sempre impegnato in circa tre giorni di pre- crisi, tre giorni di crisi a letto e tre giorni di post- crisi (convalescenza) per un totale di mai meno di quattro-cinque giorni di parziale compromissione dell'autonomia; 

Nelle mie tre individuali esperienze, confrontate con tutte le pregresse, l'immunità sembra essere stata quasi immediata, senza alcuna compromissione dell'autonomia.

Se (beninteso, se e solo se) le future risposte individuali del mio sistema immunitario alle future probabili ondate epidemiche da flu opp sars saranno equivalenti alle tre citate sopra, per quello che mi riguarda questa problematica si è chiusa a far data dal 20 marzo 2020, indipendentemente dalle future disponibilità di vaccini anti-flu anti-sars. 

Qui l'ipotetico meccanismo di azione.

I coronavirus (come i virus flu a causa di orthomyxoviridae) si duplicano nelle mucose orale e nasale; il capside virale ( e.g. Chung-ke Chang et al. Antiviral Res. 2014 Mar. https://pubmed.ncbi.nlm.nih.gov/24418573/ ) in presenza di alcool probabilmente si apre per denaturazione proteica e questo consente a un sistema immunitario fisiologicamente attivo di leggere sia il capside (che dovrebbe comunque conservare la struttura primaria) sia parti della sua metameccanica molecolare interna; 

Anche

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes 

(quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

Keywords: virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

PS: certo è che i colleghi biomedici (qualunque cosa si intenda per  'colleghi' ), con l'epifanie SARS (Nov 2002, Guangdong, China; MERS,  Nov 2012, Gedda, Saudi Arabia, SARS-COV-2, 2019-2020, Wuhan, China) non sembra abbiano mostrato il consueto brillamento delle proprie loro medesime - senz'alcun dubbio elevatissime - potenzialità.  Per modo di dire ed anzicheforse ... Forse, talvolta, si tende a sottovalutare la lezione del Maestro, indimenticato, indimenticabile Jelly Roll:  "Amico, qualunque cosa suonerai ..."   https://flashontrack.blogspot.com/search?q=jelly+roll

# life; apropos of #1or2achoos from Wuhan ...

Messrs. A, B, C & D state - between the lines, undertrack, at least a year late -

Commissione DuPre (Dubbio e Precauzione ) live streaming 8/12/2021 

https://youtu.be/_ZLFlY7y_2w

that the official anti covid19 apparatus it appears to be a big, very big mess (i.e. 'un grande pastrokkio') ...

probably Messrs. A, B, C & D could be accused of being thieves, sexual maniacs, they could block their career and make their spouses do twenty years of precariousness ...

their future pensioners' allowance could be taken away or reduced ... 

as well as more ... 

I suppose & anzicheforse ...

luckily for everyone, the 'bushman  variant' of sarscov-2 (Covid-19 B.1.1.529 Omicron) 

Republic of Botswana - new covid 19 variant detected in Botswana -  Presidential covid-19 task force.

https://pbs.twimg.com/media/FFC53NUXIAEqae5?format=jpg&name=large 

could save in short-term, perhaps, the world from this big trouble (i.e.  'grande impiccio').

Here there are three simple questions: 

(a) Why in anticipation of the 'great tea trolley disaster' (after SARS appearance in Nov 2002, Guangdong, China; after MERS in Nov 2012, Gedda, Saudi Arabia) spray forms of antiviral drugs (e.g. remdesivir,  remdesivir like) have not been prepared?

e.g.  https://pubmed.ncbi.nlm.nih.gov/?term=antiviral+drugs+sars-cov-2

(b) Why in the meantime, hitech reusable anti-viral anti-bacterial fabrics not been studied and tested?

(c) Does it seem serious to propose a vaccine - to treat every six/eight months eight billion people inside a window of 15/30 days - to confine (sic) a mutant virus (one mutation every week) that is transmitted by air? 

Also 

the unmentionable GTTD - Great Tea Trolley Disaster, by Bristow

https://flashontrack.blogspot.com/search?q=Great+Tea+Trolley+Disaster

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes 

(quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

keyword 'bosciman*' | 'nomad*' in Notes

(quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=boscimane

https://inkpi.blogspot.com/search?q=boscimani

https://inkpi.blogspot.com/search?q=nomade

https://inkpi.blogspot.com/search?q=nomadi

keyword 'bushmen' | 'nomads' in FonT 

https://flashontrack.blogspot.com/search?q=bushmen

https://flashontrack.blogspot.com/search?q=nomads

keywords: virus, coronavirus, sars, mers, sars-cov-2, covid-19, 2019ncov, bushman  variant, B.1.1.529, Omicron, 1or2achoos, mask

# life: apropos of '1or2achoos' (from Wuhan), 'Shame on us', by Jay.

<< The year 2003 was an ominous one for emerging infectious diseases. A pair of deadly influenza strains had leapt from birds to humans in Hong Kong and the Netherlands. And a new coronavirus was spreading around the world causing a mysterious illness that became known as severe acute respiratory syndrome, or SARS. Many experts feared they were watching the start of a global pandemic. Fortunately, the worst-case scenario never materialized. But it was a close-enough call for Robert Webster, a leading authority on avian influenza, to start urging scientists and policymakers to prepare for the next outbreak. One of his top recommendations: develop and stockpile drugs that target a wide range of viral pathogens. Drug researchers did not heed his call. After the SARS threat subsided, interest evaporated — and the world paid the price. “The scientific community really should have developed universal antivirals against SARS,” says Webster, now an emeritus member of St Jude Children’s Research Hospital in Memphis, Tennessee. “Then we would have had something in the stockpile for the emergence of COVID,” which is a caused by SARS-CoV-2, a close relative of the virus responsible for SARS. Another warning shot came in 2012, when Middle East respiratory syndrome (MERS) — caused by another relative of SARS-CoV-2 — started spreading through a handful of countries. Still, the drug shelves remained largely bare — a fact that Jay Bradner, president of the Novartis Institutes for BioMedical Research in Cambridge, Massachusetts, regards as “regrettable”. >>️

<< Shame on us, (..) We can be better prepared. >> Jay Bradner.️

<< We need an arsenal, >> Kara Carter.

<< It’s hard to convince a company to make a drug against something that doesn’t exist. >>️  Timothy Sheahan.

<< There’s a lot of work that needs to be done, (..) We don’t want to have another year like 2020, (..) and we don’t have to, if we do the work in advance. >> Nat Moorman.️

️

Elie Dolgin. The race for antiviral drugs to beat COVID — and the next pandemic. Despite dire warnings, a stockpile of ready compounds to fight viral pandemics was sorely lacking. Can drugmakers finally do the right thing? Nature 592, 340-343. doi: 10.1038/ d41586-021-00958-4. Apr 14, 2021. 

https://www.nature.com/articles/d41586-021-00958-4

Also

keyword 'virus' | 'sars-cov-2' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

apropos of "herd immunity" ... , FonT,  Mar 16, 2020.

https://flashontrack.blogspot.com/2020/03/life-apropos-of-herd-immunity.html

# life: apropos of 1or2achoos (from Wuhan (?)) ; CD8+ T cell and early mucosal IgA responses seem strongly associated with viral (SARS-CoV-2) control.

<< the earliest stages of SARS-CoV-2 infection remain poorly characterized. Wagstaffe et al. conducted a human SARS-CoV-2 infection challenge study, enabling analysis of the innate and adaptive immune responses during the early postexposure period. (..) Modeling of the immune response identified CD8+ T cell and early mucosal IgA responses as strongly associated with viral control, >> Claire Olingy.  ️

Helen R. Wagstaffe, Ryan S. Thwaites, et al. Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults. Sci Immunol. Vol 9, Issue 92. doi: 10.1126/ sciimmunol.adj9285. Feb 9, 2024. 

https://www.science.org/doi/10.1126/sciimmunol.adj9285   

Also: aproposito di '1or2achoos' (da Wuhan (?)). FonT.  jul 13, 2022. 

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html 

Also: sars, covid, 1or2achoos, virus, in  https://www.inkgmr.net/kwrds.html

Keywords:  sars, covid, 1or2achoos, virus, mucosa, early viral control 

# gst: apropos of 1or2achoos (e.g. from Wuhan), the dynamics of turbulence in a fluid puff

<< Turbulence is everywhere -- in the movement of the wind, the ocean waves and even magnetic fields in space. It can also be seen in more transient phenomena, like smoke billowing from a chimney, or a cough. (..) Understanding this latter type of turbulence -- called puff turbulence -- is important not only for the advancement of fundamental science, but also for practical health and environmental measures, >>️

<< The very nature of turbulence is chaotic, so it's hard to predict, (..) Puff turbulence, which occurs when the ejection of a gas or liquid into the environment is disrupted, rather than continuous, has more complicated characteristics, so it's even more challenging to study. But it's of vital importance -- especially right now for understanding airborne transmission of viruses like SARS-CoV-2. >>️ Marco Edoardo Rosti. 

<< The new model, (..) includes how minute fluctuations within the puff behave, and how both large-scale and small-scale dynamics are impacted by changes in temperature and humidity. (..) at cooler temperatures (15°C or lower), (AA) model deviated from the classical model for turbulence. >>️

<< In the classical model, turbulence reigns supreme -- determining how all the little swirls and eddies within the flow behave. But once temperatures dipped, buoyancy started to have a greater impact. >>

<< The effect of buoyancy was initially very unexpected. It's a completely new addition to the theory of turbulent puffs,>> Marco Edoardo Rosti. ️

Secrets of COVID-19 transmission revealed in turbulent puffs. Okinawa Institute of Science and Technology (OIST). Aug 26, 2021. 

https://www.sciencedaily.com/releases/2021/08/210826111729.htm

Andrea Mazzino, Marco Edoardo Rosti. Unraveling the Secrets of Turbulence in a Fluid Puff. Phys. Rev. Lett. 127, 094501. Aug 25, 2021. 

https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.127.094501

Also

keyword 'drop' | 'droplet' in FonT:

https://flashontrack.blogspot.com/search?q=drop

https://flashontrack.blogspot.com/search?q=droplet

keyword 'turbulence' in FonT:

https://flashontrack.blogspot.com/search?q=turbulence

keyword 'turbolento' | 'turbolenza' in Notes (quasi-stochastic poetry): 

https://inkpi.blogspot.com/search?q=turbolento

https://inkpi.blogspot.com/search?q=turbolenza

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

# life: oops! IT entity (i.e. 1or2 'achoo!' from Wuhan) seems to be alive ... here a review of candidate drugs against SARS-CoV-2 and COVID-19.

<< Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. >>

McKee DL, Sternberg A, et al. Candidate drugs against SARS-CoV-2 and COVID-19. Pharmacol Res. 2020;157:104859. doi: 10.1016/ j.phrs.2020.104859

https://pubmed.ncbi.nlm.nih.gov/32360480

Also: 

(this is a keyword list, copy & paste in Search Pubmed)

("antiviral drugs"[all] AND "SARS-CoV-2"  AND  "last 1 years"[PDat])

http://www.ncbi.nlm.nih.gov/pubmed/

Also: 

keyword 'virus' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

# life: a weird revisited from ethnomedicine inside an approach in epidemiology, the 'saliva healers' vs. 'herd immunity'.

(A) 

<< chiamati 'dottori della saliva' >>

️

A pain-suppressive effect. Notes (quasi-stochastic poetry). Nov 14, 2006.    

https://inkpi.blogspot.com/2006/11/2086-pain-suppressive-effect.html

(B) 

Apropos of "herd immunity" ... FonT. Mar 16, 2020. 

https://flashontrack.blogspot.com/2020/03/life-apropos-of-herd-immunity.html

(C) 

<< During 2020, most schools were never pro-actively closed to hinder virus spreading (with compulsory physical attendance required by law in Sweden and no option for distance or home learning)  >> 

<< Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives. >>️

<< The Swedish Strategy was also influential abroad, and became an argument in other countries including, among others, the United States (US), United Kingdom (UK) and Australia, to loosen restrictions >>️ 

<< Supporters of the natural herd-immunity strategy promoted a widespread “controlled” spread in society, to obtain herd-immunity without vaccination >>️ 

<< Email conversations and statements from the State Epidemiologist and others show that they at least speculated on the use of children to acquire herd-immunity, while at the same time publicly claiming children played a negligible role in transmission and did not become ill >> 

<< During 2020, however, Sweden had ten times higher COVID-19 death rates compared with neighbouring Norway. >>️️

️

Nele Brusselaers, David Steadson, et al. Evaluation of science advice during the COVID-19 pandemic in Sweden. Humanit Soc Sci Commun 9, 91. doi: 10.1057/ s41599-022-01097-5. Mar 22, 2022.  

https://www.nature.com/articles/s41599-022-01097-5

Also

keyword 'saliva' in Notes  (quasi-stochastic poetry)   

https://inkpi.blogspot.com/search?q=saliva

keyword 'saliva' in FonT   

https://flashontrack.blogspot.com/search?q=saliva

keyword 'virus' | 'sars-cov-2' | 'sars' in FonT   

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=sars-cov-2

https://flashontrack.blogspot.com/search?q=sars

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

Also

(here a homemade mask with a pre  antiviral spray mixture)

A funky, immediate approach of the sneezing from Wuhan (a relative safe barrier - this device is NOT a filter). FonT. Mar 20, 2020. 

https://flashontrack.blogspot.com/2020/03/life-funky-immediate-approach-of.html

keywords: ethnomedicine, saliva, saliva healers, herd immunity, virus, coronavirus, sars, mers, 2019ncov, sarscov2, covid19, 1or2achoos 

# life: apropos of 1or2achoos (from Wuhan), here is a triptych on the subject.

Apropos of 1or2achoos from Wuhan, here is a triptych on the subject. 

( by Rhiannon Williams. The White House is split over covid’s origins. MIT - The Download. Feb 28, 2023. 

https://mailchi.mp/technologyreview.com/the-download-839722 )

(img  https://wp.technologyreview.com/wp-content/uploads/2022/01/Unknown-1.jpeg )

(1)

<< The White House said there is no consensus within the Biden administration over the origins of the Covid-19 virus, a day after the disclosure of an Energy Department assessment that the pandemic most likely originated with a leak from a Chinese lab. >>

Josh Chin, Lindsay Wise, Annie Linskey. White House Says No Consensus on Covid Origin. Comments follow Energy Department assessment that pandemic likely started with leak from Chinese lab. WSJ. Feb. 27, 2023. 

https://www.wsj.com/articles/china-rejects-u-s-assertion-that-covid-originated-from-lab-leak-fe15df0c 

(2)

<< The U.S. Energy Department has concluded that the Covid pandemic most likely arose from a laboratory leak, according to a classified intelligence report recently provided to the White House and key members of Congress. The shift by the Energy Department, which previously was undecided on how the virus emerged, is noted in an update to a 2021 document by Director of National Intelligence Avril Haines’s office. >>

Michael R. Gordon, Warren P. Strobel. Lab Leak Most Likely Origin of Covid-19 Pandemic, Energy Department Now Says. U.S. agency’s revised assessment is based on new intelligence. WSJ. Feb. 26, 2023.

https://www.wsj.com/articles/covid-origin-china-lab-leak-807b7b0a

(3)

<< Shi Zhengli has spent years at the Wuhan Institute of Virology researching coronaviruses that live in bats. Her work has come under fire as the world tries to understand where covid-19 came from. >>

Jane Qiu. Meet the scientist at the center of the covid lab leak controversy.  MIT Tech Rev. Feb 9, 2022. 

https://www.technologyreview.com/2022/02/09/1044985/shi-zhengli-covid-lab-leak-wuhan/

Also

<< Qui l'approccio semplice, diretto, efficace che ho usato per la prevenzione ed eventuale gestione personale dell'entità coronavirus /  SARS-COV-2 (SARS: Severe Acute Respiratory Syndrome ) >>

(Here is the simple, direct, effective approach that I used for the prevention and possible personal management of the coronavirus entity)

# life: aproposito di '1or2achoos' (da Wuhan (?)) ... FonT. Jul 13, 2022. 

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Also

keyword 'virus' in FonT

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes 

(quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

Keywords:  virus, flu, coronavirus, 2019-ncov, 2019ncov, SARS-CoV-2, sarscov2, covid-19, covid19, 1or2achoos, mask

# life; the hypothesis of early treatment (at home) of the virus sars-cov-2

Figure 1 - Proposed maladaptive hyperinflammatory response to SARS-CoV-2 infection (Perico N, Cortinovis M, Suter F, Remuzzi G. (2022))

<< A few observational studies have tested NSAIDs [non-steroidal anti-inflammatory drugs] (especially  relatively selective COX-2 inhibitors), often as part of multipharmacological protocols, for early outpatient treatment of COVID-19. The findings from these studies are promising and point to a crucial role of NSAIDs for the at-home management of people with initial COVID-19 symptoms. >>

<< Celecoxib, ibuprofen, and nimesulide should be avoided in children younger than 12 years, whereas aspirin should be taken only under prescription and at the dose recommended by the family doctor. >>️

️

Norberto Perico, Monica Cortinovis, Fredy Suter, Giuseppe Remuzzi. Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents. The Lancet Infectious Diseases. doi: 10.1016/ S1473-3099(22)00433-9. Aug 25, 2022. 

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00433-9/fulltext

FonT

therefore the deadly infection by sars-cov-2 that has generated so much suffering,  pain, and dead everywhere it is recently hypothesized that it could easily be treated at home (an early treatment) with some success.

Also

keywords 'covid-19' and 'NSAIDs' in PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=covid-19+NSAIDs&filter=datesearch.y_1

Also

aproposito di '1or2achoos' (da Wuhan (?)) ... FonT. Jul 13  2022.

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Keywords: virus, coronavirus,  sarscov2, 2019ncov, covid19, 1or2achoos

# life: apropos of fuzzy cooperation, Ralph fuzzy mixture vs. world fuzzy dance ...

<< In 2013, the American virologist Ralph Baric approached Zhengli Shi at a meeting. Baric was a top expert in coronaviruses, with hundreds of papers to his credit, and Shi, along with her team at the Wuhan Institute of Virology, had been discovering them by the fistful in bat caves. In one sample of bat guano, Shi had detected the genome of a new virus, called SHC014, that was one of the two closest relatives to the original SARS virus, but her team had not been able to culture it in the lab. >>️

<< Baric had developed a way around that problem—a technique for “reverse genetics” in coronaviruses. Not only did it allow him to bring an actual virus to life from its genetic code, but he could mix and match parts of multiple viruses. He wanted to take the “spike” gene from SHC014 and move it into a genetic copy of the SARS virus he already had in his lab. The spike molecule is what lets a coronavirus open a cell and get inside it. The resulting chimera would demonstrate whether the spike of SHC014 would attach to human cells. >>️

<< Just as when you trade in part of a poker hand for fresh cards, there was no way of knowing whether the final chimeras would be stronger or weaker. >>

<< If you study a hundred different bat viruses, your luck may run out. >> Ralph Baric. 

<< In 2014, the NIH awarded a five-year, $3.75 million grant to EcoHealth Alliance to study the risk that more bat-borne coronaviruses would emerge in China, using the same kind of techniques Baric had pioneered. Some of that work was to be subcontracted to the Wuhan Institute of Virology. >>

<< Consider this hypothetical scenario, (..) An important gain-of-function experiment involving a virus with serious pandemic potential is performed in a well-regulated, world-class laboratory by experienced investigators, but the information from the experiment is then used by another scientist who does not have the same training and facilities and is not subject to the same regulations. In an unlikely but conceivable turn of events, what if that scientist becomes infected with the virus, which leads to an outbreak and ultimately triggers a pandemic >>  Anthony Fauci (director of the NIH’s National Institute of Allergy and Infectious Diseases) (2012).

️

<< Paul’s grilling of Fauci brought new scrutiny to the relationship between Ralph Baric’s lab at UNC and Zhengli Shi’s at WIV, with some narratives painting Baric as the Sith master of SARS and Shi as his ascendant apprentice. They did share resources—for example, Baric sent the transgenic mice with human lung receptors to Wuhan.  >>

️

<< During a hearing on May 11, 2021, Senator Rand Paul confronted Anthony Fauci over funding of bat-virus research by the National Institutes of Health. >>️

<< The NIH has still not fully explained its decision-making and did not reply to questions. Citing a pending investigation, it has declined to release copies of the grant that sent the Wuhan institute about $600,000 between 2014 and 2019. It has also revealed little about its new system for assessing gain-of-function risks, which is carried out by an anonymous review panel whose deliberations are not made public. >>️

️

Rowan Jacobsen. Inside the risky bat-virus engineering that links America to Wuhan. China emulated US techniques to construct novel coronaviruses in unsafe conditions. MIT TechRev. Jun 29, 2021. 

https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan

Also

<< " ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 4, 2008. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

<< in attesa del beffardo tsunami. >> in: 1619 - onda di carambola. Notes. Nov 29, 2004. (quasi-stochastic poetry).

️

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

keyword 'virus' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

keyword 'virus' in FonT 

https://flashontrack.blogspot.com/search?q=virus

keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=caos

https://inkpi.blogspot.com/search?q=caotico

FonT

no surprise, no amazement here, I know chickens behaviors. 

<< Ricordo che quando si era ragazzi, negli anni sessanta, ... >> in: 2157 - il pino di takata matsubara. Apr 1, 2011. Notes. 

https://inkpi.blogspot.com/2011/04/2157-il-pino-di-takata-matsubara.html

# life: inside the mysterious (i.e. secret) Yunnan cave, a key to the bizarre jump of the Chinese covid-19 virus

<< In 2004, deep in the wilderness of China’s Yunnan province, a group of scientists from the Wuhan Institute of Virology discovered a cave full of wild bats carrying hundreds of SARS-related viruses. Their work, published in a draft paper in 2005, ( Science. 2005 Oct 28;310(5748):676-9. Epub 2005 Sep 29.  https://www.ncbi.nlm.nih.gov/pubmed/16195424 ) unearthed the link between SARS (severe acute respiratory syndrome) and bats for the first time. >>

<< Now the virologist who led that study, Shi Zhengli, has revealed one of the strains found in that cave - the exact location of which is a closely guarded secret - is almost identical to the 2019-nCoV coronavirus which has so far killed at least 1,115 people and infected more than 45,000 worldwide. >>

<< Professor Shi ran the genome sequence of 2019-nCoV - now officially known as COVID-19 - through the bat-related virus database she built up over ten years and found it was a 96 per cent match to a virus found in the droppings of horseshoe bats. >>

Marnie O’Neill. Mysterious bat cave in Chinese wilderness could hold key to coronavirus. news.com.au Feb 13, 2020.

https://www.news.com.au/lifestyle/health/health-problems/mysterious-bat-cave-in-chinese-wilderness-could-hold-key-to-coronavirus/news-story/530063aeb9de7020e626f1c4839b9777

Also

Zhou, P., Yang, X., Wang, X. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. doi: 10.1038/s41586-020-2012-7. Jan 29, 2020.

https://www.nature.com/articles/s41586-020-2012-7

Human uses of bats (also in chinese traditional medicine). Wikipedia. Last edited 11 days ago by Enwebb.

https://en.m.wikipedia.org/wiki/Human_uses_of_bats

Bat as food. Wikipedia. Last edited 7 days ago by Enwebb.

https://en.m.wikipedia.org/wiki/Bat_as_food

# life: a tiny pill against two unfavorable hypotheses on serial coronavirus pandemics - to avoid the socio-economic psycho-behavioral fallout caused by 1or2achoos (e.g. from Wuhan)

<< Pfizer Inc. said it has begun human safety testing of a new pill to treat the coronavirus that could be used at the first sign of illness. If it succeeds in trials, the pill could be prescribed early in an infection to block viral replication before patients get very sick. The drug binds to an enzyme called a protease (Pfizer’s oral protease inhibitor, code-named PF-07321332,) to keep the virus from replicating. >>

<< In lab tests, it worked against many coronaviruses, including the original SARS virus and MERS. Additionally, the coronavirus protease doesn’t mutate much, which means the therapy is likely to work equally well against numerous variant strains, >>

️

<< This is really a potential game changer, >>️  Mikael Dolsten️

Robert Langreth. Pfizer Begins Human Trials of New Pill to Treat Coronavirus. 

Mar 23, 2021 17:38 CET. 

https://www.bloomberg.com/news/articles/2021-03-23/pfizer-begins-human-trials-of-new-pill-to-treat-coronavirus

Christie Aschwanden. Five reasons why COVID herd immunity is probably impossible. Nature 591, 520-522. doi: 10.1038/ d41586-021-00728-2. Mar 18, 2021. 

https://www.nature.com/articles/d41586-021-00728-2

Angela L. Rasmussen, Saskia V. Popescu. SARS-CoV-2 transmission without symptoms.  Science, 2021; 371 (6535): 1206-1207 doi: 10.1126/ science.abf9569   

https://science.sciencemag.org/content/371/6535/1206

Also

keyword 'virus' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

# life: Hollywood movies revisited, you'll have to be very careful, a cycle of panic and neglect (e.g. about an 'Entity X') is beginning to repeat.

<< Your Highnesses, Your Excellencies,

Dear colleagues and friends, (..).

I thank Your Highnesses for your hospitality, for your steadfast support for the World Health Organization and global health, and for the opportunity to address you today.  >>️

<< On the 12th of February 2018 – exactly six years ago – I stood on this stage and said the world was not prepared for a pandemic, and expressed my concern at that time that a pandemic could happen anytime. >>️

<< As you remember, less than two years later, in December 2019, the COVID-19 pandemic struck, and indeed, the world was not prepared. >>️

<< Today I stand before you, in the aftermath of COVID-19,

With millions of people dead,

With social, economic and political shocks that reverberate to this day, >>️

<< The cycle of panic and neglect is beginning to repeat. >>️

<< It may be caused by an influenza virus, or a new coronavirus, or it may be caused by a new pathogen we don’t even know about yet – what we call Disease X. >>️

WHO Director-General's speech at the World Governments Summit – 12 Feb 2024.️ WHO. 

https://www.who.int/director-general/speeches/detail/who-director-general-s-speech-at-the-world-governments-summit---12-february-2024   

Also: sars, covid, 1or2achoos, virus, in https://www.inkgmr.net/kwrds.html

Keywords: sars, covid, 1or2achoos, virus, disease X

# life: they ( NIH, Ralph Baric’s Univ.of North Carolina lab, Wuhan Instit.of Virology ) never created a supervirus, anzicheforse ...

<< 

In May, the coronavirus researcher Ralph Baric found himself at the center of the debate over gain-of-function research ( https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan ), in which scientists engineer new properties into existing viruses. And during a congressional hearing, Senator Rand Paul implied that the National Institutes of Health had been funding such research at both the Wuhan Institute of Virology and Baric’s University of North Carolina lab, and that the two labs had been collaborating to make “superviruses”. Baric released a statement clarifying the research in question did not qualify as gain-of-function, and none of the SARS-like coronaviruses he’d used in the experiments were closely related to SARS-CoV-2, yet that did little to quell questions about the role his research may have played in furthering scientists’ ability to modify coronaviruses in potentially dangerous ways. Baric believes such research is essential to the development of vaccines and other countermeasures against emerging viruses, a project he has been engaged in for more than 20 years. His research laid the groundwork for the first approved anti-covid drug and helped speed the development of the mRNA vaccines that have proved so pivotal. 

MIT Technology Review recently asked Baric to explain what constitutes a gain-of-function experiment, why such research exists, and whether it could have played any role in the pandemic. Read the full interview. ( https://www.technologyreview.com/2021/07/26/1030043/gain-of-function-research-coronavirus-ralph-baric-vaccines )

>>️

Rowan Jacobsen. Why researchers need to tinker with viruses. The Download from MIT Technology Review newsletters@technologyreview.com  

The Download from MIT (mail). Jun 26, 2021 14:12

Also

<< ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 04, 2008. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

keyword 'virus' in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=virus

keyword 'virus' in FonT 

https://flashontrack.blogspot.com/search?q=virus

# life: apropos of 'dancing at a fixed point'

the last interview to Dr Albert Bourla (Pfizer) about the annual (or maybe semi-annual (?)) shot reiteration of the vaccine against #sars-cov-2   remember to me the 'homoclinic dynamics' that I cited at the 13th Meeting of the Internat Epidemiol Associat - IEA (Sydney, 1993) ... after a large trajectories started at zero point (i.e.  the fixed point), the final point of the dynamic returns at the same zero point ...

<< People will be likely to need to have annual Covid vaccinations for many years to come, the head of Pfizer [Dr Albert Bourla ] has told the BBC >>️

Fergus Walsh. Pfizer boss: Annual Covid jabs for years to come. Dec 2, 2021. 

https://www.bbc.com/news/health-59488848

Who knows if there is a convincing reason that explains why to treat a virus with a high frequency of mutations one should prefer a vaccine approach instead of an antiviral drug ...

to find: 'antiviral drugs covid-19'  

https://pubmed.ncbi.nlm.nih.gov/?term=antiviral+drugs+covid-19&filter=datesearch.y_1

Apropos of 'homoclinic orbits' ...

<< the reinjection of the departing trajectories in the vicinity of an unstable fixed point of the saddle-focus type [..] is frequently associated with the emergence of orbits of a rather exceptional type known as 'homoclinic orbits'. These are trajectories that leave the fixed point but come back to it; in other words, they tend to the same limit when time t goes to +∞ as well as to -∞ . [..]. Homoclinic orbits are very sensitive to variation of parameter [parms] values and are generally destroyed if the [parms] do not satisfy a strict equality (in the terminology of [..] they are structurally unstable). However, for nearby values of the [parms] their disappearance leaves a very rich structure of orbit in phase space, some of which behave chaotically. >>️

Nicolis G., Prigogine I. Exploring complexity. Freeman, NY (1989): 130-131.

https://www.amazon.com/Exploring-Complexity-Introduction-Gregoire-Nicolis/dp/0716718596

Apropos of: [+∞ , -∞] plus infinity, minus infinity; 

<< In modern mysticism, the infinity symbol has become identified with a variation of the ouroboros, an ancient image of a snake eating its own tail that has also come to symbolize the infinite, [..] >> 

https://en.m.wikipedia.org/wiki/Infinity_symbol

Also 

Onda omoclina. Notes. Tuesday, Jan  11, 2005 (quasi-stochastic poetry)

<< ed assistere al mutar dell' onda omoclina / (..) >>

️

https://inkpi.blogspot.com/2005/01/1639b-onda-omoclina.html

Also

Inchingolo GM.  Cultural transitions and epidemiology.  Proceedings of the 13th Scientific Meeting of the International Epidemiological Association - IEA, Sydney, Australia, Sept 26-29, 1993: 129.   Med Hypotheses 1994; 43(4): 201-206.

https://pubmed.ncbi.nlm.nih.gov/7838001/

Also

Onda di carambola. Notes. Nov  29, 2004. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

keywords: life, dance, fixed point, homoclinic orbits, instability, chaos,  virus, coronavirus, sars-cov-2,  covid19, 2019ncov, drugs, antiviral drug, vaccine, jabs, Covid jabs.

# life: simnotrelvir, a Chinese pill anti covid-19

<< A drug called simnotrelvir speeds up recovery from mild to moderate COVID-19 by about 1.5 days, relieving symptoms such as fever, cough and runny nose.  >>

<< Whether it can help people who are at high risk of hospitalization and death from COVID-19 is still unclear. >>️️

Saima Sidik. Potent new pill provides COVID relief for the masses. Nature. doi: 10.1038/d41586-024-00117-5. Jan 17,  2024. 

https://www.nature.com/articles/d41586-024-00117-5

Bin Cao, Yeming Wang, et al. Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. N Engl J Med 2024; 390:230-241. doi: 10.1056/NEJMoa2301425. Jan 18, 2024.

https://www.nejm.org/doi/10.1056/NEJMoa2301425

FonT: if it is (another) 'pastroky', you can redirect yourself towards an alcohol plus peroxide solution... just to put the classic patch on it. 

Also:  a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia. FonT. Oct 4, 2023. 

https://flashontrack.blogspot.com/2023/10/life-proposito-di-1or2achoos-da-wuhan.html

Also: 1or2achoos, sars, covid, virus, pastroky, in:   https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life: Black Death way revisited, the hypothesis, by Parag.

<< Good afternoon to everyone online and in the room. (..) Since yesterday, Denmark, Estonia, Lithuania, Netherlands and Nigeria have all reported their first cases. All these cases have links to Italy. 24 cases have been exported from Italy to 14 countries, and 97 cases have been exported from Iran to 11 countries. >>  

Tedros Adhanom Ghebreyesus.

WHO Director-General's opening remarks at the media briefing on COVID-19. WHO. Feb 28, 2020.

https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---28-february-2020

<< A striking overlap exists between the path of today's viral spread and the path of the Black Death in the 1300s. >>

<< It is, of course, far too soon to make such dire predictions about Covid-19. But a striking overlap exists between the path of today's viral spread and the path that emerged in the 1300s. >>

<< The 14th-century plague is said to have originated in northwestern China, with bacteria contracted from marmots. Hebei Province bore the brunt of China’s plague fatalities, with 5 million of its residents perishing in the 1330s. Making its way westward via Silk Road merchants and caravans, the plague took several years to reach Persia, where it killed the Khan overlord Abu Said as well as half the population. In 1347, it entered Europe via Italy’s port of Genoa. >>

<< Now compare that to what we’re seeing today with Covid-19. This time around, the source of illness may have been pangolins or bats instead of marmots. It started in Wuhan, which just happens to be Hebei's capital. The coronavirus reached Iran in a couple of weeks, and so far has infected hundreds of people, even the country’s deputy health minister. Next to Iran, the next worst outbreak is in Italy, with more than 300 cases and rising quickly- and likely spreading through Europe exactly as the plague did centuries ago. >>

<< It is, perhaps no coincidence that, in the past two decades, China has been the origin of SARS, the swine flu, and now the Covid-19 coronavirus. Nor should we be surprised that Iran and Italy have emerged, once more, as waypoints for pandemic spread. What do Iran and Italy have in common today? They are two major anchors of China’s Belt and Road Initiative- also known as the 21st century’s new Silk Roads. >>

Parag Khanna. IDEAS. Covid-19 Is Traveling Along the New Silk Road. Wired. Feb 28, 2020.

https://www.wired.com/story/covid-19-is-traveling-along-the-new-silk-road/

Also

keyword 'virus' by FonT

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' by Notes

https://inkpi.blogspot.com/search?q=virus

# life: a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia

a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia di inizio dei 6 flu|covid che ho contratto dal gen2020 ad oggi con i relativi tempi di 'smorzamento' dell'infezione, trattati nebulizzando una miscela di alcool e H2O2 ( https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html )

(1) 2020.04.11-16:04 ~12h (non vaccinato)

(2) 2021.09.01-07:40 ~12h (non vaccinato)

(3) 2022.06.11-08:26 18-36h (+1mese post vaccino, 3dosi)

(4) 2022.12.24-07:52 ~24h 

(5) 2023.02.28-12:09 ~24h 

(6) 2023.04.08-09:32 24-36h 

I tempi necessari per 'spegnere' questi  flu|covid sono tutti notevolmente inferiori (~80%) rispetto alle pregresse forme di flu che ho contratto delle quali ho memoria.

Invece non ho altre parole da aggiungere per commentare i diversi argomenti associabili a '1or2achoos' dal febbraio 2020 ad oggi.

Potrei (e.g. expectedepidemic, lockdown, greenpass, indicatori, statistiche, accademieacucciabili, sadichepredazioni, bucodibilancio, pastroky, ...) nelle bizzarre forme della poetica quasistocastica ( https://inkpi.blogspot.com/ ), ma mi astengo.

Anche: "Ricordo che quando si era ragazzi". in: "il pino di takata matsubara". Notes. Apr 1, 2011. https://inkpi.blogspot.com/2011/04/2157-il-pino-di-takata-matsubara.html

Anche: "e Da-Li' si sparse pell'aere". in: "cracker tendenziali". Notes. Apr 4, 2008. https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

Anche: "in attesa del beffardo tsunami". in: "onda di carambola". Notes. Nov 29, 2004. 

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

Anche: "aproposito di '1or2achoos' (da Wuhan (?)) ...". FonT. Jul 13, 2022. https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Anche: 1or2achoos, sars, covid, virus, pastroky, in: 

https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life: aprops of 1or2 achoo! from Wuhan (SARS-CoV-2), a mask build of 'nanofibers randomly land on a collector to create a sort of non-woven mesh'

<< Recently, students from BYU’s College of Engineering teamed up with Nanos Foundation to develop a nanofiber membrane that can be sandwiched between the cloth pieces in a homemade mask. While today’s typical cloth mask might block fewer than 50% of virus particles, the membrane — which can be made using simple, inexpensive materials — will be able to block 90 to 99% of particles, increasing effectiveness while preserving breathability. The membranes are made through a process called “electrospinning,” which involves dissolving a polymer plastic in a solution and then using an electrical current to move a droplet of the polymer downward through a needle. As the droplet accelerates, it stretches into a very small fiber that retains a static charge. >>

<< Those nanofibers randomly land on a collector to create a sort of non-woven mesh, >> Katie Varela.

Christie Allen. With innovative nanofiber membranes, cloth masks’  efficacy goes up to 99%. Oct 21, 2020.

https://news.byu.edu/intellect/with-new-byu-created-nanofiber-membranes-cloth-masks-efficacy-goes-up-to-99 

https://phys.org/news/2020-10-nanofiber-membranes-masks-efficacy.html   

Also

keyword 'virus' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus