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Visualizzazione post con etichetta sars. Mostra tutti i post

mercoledì 4 dicembre 2024

# life: apropos of saliva healers, herd immunity revisited and now hypothetically approachable even within NIH

<< President-elect Donald Trump is tapping Dr. Jay Bhattacharya, a Stanford University health researcher, to be the next director of the National Institutes of Health (NIH). >>
️
<< Bhattacharya was one of three authors of the document (#1). The declaration called for speeding herd immunity by allowing people at low risk to get infected while protecting those most vulnerable, like the elderly. >>

Rob Stein. Trump turns to critic of COVID mandates to run NIH. npr.org. 
Nov 26, 2024. 

<< The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk. We call this Focused Protection. >>
️
(#1) - Martin Kulldorff, Sunetra Gupta, Jay Bhattacharya. Great Barrington Declaration. Oct 4, 2020. https://gbdeclaration.org/

FonT
From my point of view 'herd immunity'  can be engineered if and only if, even in the case of sars-covid-19 or flu, simultaneous protection is used with an effective, easy available, antiviral drug.

In this regard, a non-compassionate but logical easy approach could be the indirect inhalation of alcohol ~70% already at the first signs of rhinorrhea, as follows:

(-) start self-treatment (spray plus cotton mask):

(-) outcomes

Ultimately, here it could hypothesize a case of historic, singular checkmate of 'one against all'. Anzicheforse?

Also: drop, saliva, sars* covid* (aka 1or2achoos), virus, ethno, Mr. Donald, POTUS, tit-for-tat, game, in https://www.inkgmr.net/kwrds.html 

Keywords: life, drop, saliva, saliva healers, herd immunity, sars, mers, 2019ncov, sarscov2, covid19, coronavirus, 1or2achoos, virus, ethno, ethnomedicine, Donald, POTUS, tit-for-tat, game

PS: I couldn't say why, but in certain contexts, the incipit of an answer that the physicist Enrico Fermi https://it.m.wikipedia.org/wiki/Enrico_Fermi  gave to a journalist always comes back to my mind: 'the physics that is done in our laboratory ...' . 

An example of exceptional, clear, even poetic analysis and synthesis skills (in only 8 words).


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mercoledì 6 marzo 2024

# life: apropos of 1or2achoos (from Wuhan (?)) ; CD8+ T cell and early mucosal IgA responses seem strongly associated with viral (SARS-CoV-2) control.

<< the earliest stages of SARS-CoV-2 infection remain poorly characterized. Wagstaffe et al. conducted a human SARS-CoV-2 infection challenge study, enabling analysis of the innate and adaptive immune responses during the early postexposure period. (..) Modeling of the immune response identified CD8+ T cell and early mucosal IgA responses as strongly associated with viral control, >> Claire Olingy.  ️

Helen R. Wagstaffe, Ryan S. Thwaites, et al. Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults. Sci Immunol. Vol 9, Issue 92. doi: 10.1126/ sciimmunol.adj9285. Feb 9, 2024. 

Also: aproposito di '1or2achoos' (da Wuhan (?)). FonT.  jul 13, 2022. 

Also: sars, covid, 1or2achoos, virus, in  https://www.inkgmr.net/kwrds.html

Keywords:  sars, covid, 1or2achoos, virus, mucosa, early viral control 


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martedì 5 marzo 2024

# life: Hollywood movies revisited, you'll have to be very careful, a cycle of panic and neglect (e.g. about an 'Entity X') is beginning to repeat.

<< Your Highnesses, Your Excellencies,
Dear colleagues and friends, (..).
I thank Your Highnesses for your hospitality, for your steadfast support for the World Health Organization and global health, and for the opportunity to address you today.  >>️

<< On the 12th of February 2018 – exactly six years ago – I stood on this stage and said the world was not prepared for a pandemic, and expressed my concern at that time that a pandemic could happen anytime. >>️

<< As you remember, less than two years later, in December 2019, the COVID-19 pandemic struck, and indeed, the world was not prepared. >>️

<< Today I stand before you, in the aftermath of COVID-19,
With millions of people dead,
With social, economic and political shocks that reverberate to this day, >>️

<< The cycle of panic and neglect is beginning to repeat. >>️

<< It may be caused by an influenza virus, or a new coronavirus, or it may be caused by a new pathogen we don’t even know about yet – what we call Disease X. >>️

WHO Director-General's speech at the World Governments Summit – 12 Feb 2024.️ WHO. 

Also: sars, covid, 1or2achoos, virus, in https://www.inkgmr.net/kwrds.html

Keywords: sars, covid, 1or2achoos, virus, disease X


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giovedì 14 aprile 2022

# life: a weird revisited from ethnomedicine inside an approach in epidemiology, the 'saliva healers' vs. 'herd immunity'.

(A) 
<< chiamati 'dottori della saliva' >>
️
A pain-suppressive effect. Notes (quasi-stochastic poetry). Nov 14, 2006.    


(B) 
Apropos of "herd immunity" ... FonT. Mar 16, 2020. 


(C) 
<< During 2020, most schools were never pro-actively closed to hinder virus spreading (with compulsory physical attendance required by law in Sweden and no option for distance or home learning)  >> 

<< Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives. >>️

<< The Swedish Strategy was also influential abroad, and became an argument in other countries including, among others, the United States (US), United Kingdom (UK) and Australia, to loosen restrictions >>️ 

<< Supporters of the natural herd-immunity strategy promoted a widespread “controlled” spread in society, to obtain herd-immunity without vaccination >>️ 

<< Email conversations and statements from the State Epidemiologist and others show that they at least speculated on the use of children to acquire herd-immunity, while at the same time publicly claiming children played a negligible role in transmission and did not become ill >> 

<< During 2020, however, Sweden had ten times higher COVID-19 death rates compared with neighbouring Norway. >>️️
️
Nele Brusselaers, David Steadson, et al. Evaluation of science advice during the COVID-19 pandemic in Sweden. Humanit Soc Sci Commun 9, 91. doi: 10.1057/ s41599-022-01097-5. Mar 22, 2022.  


Also

keyword 'saliva' in Notes  (quasi-stochastic poetry)   


keyword 'saliva' in FonT   


keyword 'virus' | 'sars-cov-2' | 'sars' in FonT   




keyword 'virus' in Notes (quasi-stochastic poetry):


Also

(here a homemade mask with a pre  antiviral spray mixture)

A funky, immediate approach of the sneezing from Wuhan (a relative safe barrier - this device is NOT a filter). FonT. Mar 20, 2020. 


keywords: ethnomedicine, saliva, saliva healers, herd immunity, virus, coronavirus, sars, mers, 2019ncov, sarscov2, covid19, 1or2achoos 








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venerdì 10 dicembre 2021

# life; apropos of #1or2achoos from Wuhan ...

Messrs. A, B, C & D state - between the lines, undertrack, at least a year late -

Commissione DuPre (Dubbio e Precauzione ) live streaming 8/12/2021 


that the official anti covid19 apparatus it appears to be a big, very big mess (i.e. 'un grande pastrokkio') ...

probably Messrs. A, B, C & D could be accused of being thieves, sexual maniacs, they could block their career and make their spouses do twenty years of precariousness ...

their future pensioners' allowance could be taken away or reduced ... 

as well as more ... 

I suppose & anzicheforse ...

luckily for everyone, the 'bushman  variant' of sarscov-2 (Covid-19 B.1.1.529 Omicron) 

Republic of Botswana - new covid 19 variant detected in Botswana -  Presidential covid-19 task force.


could save in short-term, perhaps, the world from this big trouble (i.e.  'grande impiccio').

Here there are three simple questions: 

(a) Why in anticipation of the 'great tea trolley disaster' (after SARS appearance in Nov 2002, Guangdong, China; after MERS in Nov 2012, Gedda, Saudi Arabia) spray forms of antiviral drugs (e.g. remdesivir,  remdesivir like) have not been prepared?


(b) Why in the meantime, hitech reusable anti-viral anti-bacterial fabrics not been studied and tested?

(c) Does it seem serious to propose a vaccine - to treat every six/eight months eight billion people inside a window of 15/30 days - to confine (sic) a mutant virus (one mutation every week) that is transmitted by air? 

Also 

the unmentionable GTTD - Great Tea Trolley Disaster, by Bristow


keyword 'virus' | 'sars-cov-2' | 'sars' in FonT: 




keyword 'virus' in Notes 
(quasi-stochastic poetry):


keyword 'bosciman*' | 'nomad*' in Notes
(quasi-stochastic poetry)





keyword 'bushmen' | 'nomads' in FonT 



keywords: virus, coronavirus, sars, mers, sars-cov-2, covid-19, 2019ncov, bushman  variant, B.1.1.529, Omicron, 1or2achoos, mask


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giovedì 29 luglio 2021

# life: apropos of fuzzy cooperation, Ralph fuzzy mixture vs. world fuzzy dance ...

<< In 2013, the American virologist Ralph Baric approached Zhengli Shi at a meeting. Baric was a top expert in coronaviruses, with hundreds of papers to his credit, and Shi, along with her team at the Wuhan Institute of Virology, had been discovering them by the fistful in bat caves. In one sample of bat guano, Shi had detected the genome of a new virus, called SHC014, that was one of the two closest relatives to the original SARS virus, but her team had not been able to culture it in the lab. >>️

<< Baric had developed a way around that problem—a technique for “reverse genetics” in coronaviruses. Not only did it allow him to bring an actual virus to life from its genetic code, but he could mix and match parts of multiple viruses. He wanted to take the “spike” gene from SHC014 and move it into a genetic copy of the SARS virus he already had in his lab. The spike molecule is what lets a coronavirus open a cell and get inside it. The resulting chimera would demonstrate whether the spike of SHC014 would attach to human cells. >>️

<< Just as when you trade in part of a poker hand for fresh cards, there was no way of knowing whether the final chimeras would be stronger or weaker. >>

<< If you study a hundred different bat viruses, your luck may run out. >> Ralph Baric. 

<< In 2014, the NIH awarded a five-year, $3.75 million grant to EcoHealth Alliance to study the risk that more bat-borne coronaviruses would emerge in China, using the same kind of techniques Baric had pioneered. Some of that work was to be subcontracted to the Wuhan Institute of Virology. >>

<< Consider this hypothetical scenario, (..) An important gain-of-function experiment involving a virus with serious pandemic potential is performed in a well-regulated, world-class laboratory by experienced investigators, but the information from the experiment is then used by another scientist who does not have the same training and facilities and is not subject to the same regulations. In an unlikely but conceivable turn of events, what if that scientist becomes infected with the virus, which leads to an outbreak and ultimately triggers a pandemic >>  Anthony Fauci (director of the NIH’s National Institute of Allergy and Infectious Diseases) (2012).
️
<< Paul’s grilling of Fauci brought new scrutiny to the relationship between Ralph Baric’s lab at UNC and Zhengli Shi’s at WIV, with some narratives painting Baric as the Sith master of SARS and Shi as his ascendant apprentice. They did share resources—for example, Baric sent the transgenic mice with human lung receptors to Wuhan.  >>
️
<< During a hearing on May 11, 2021, Senator Rand Paul confronted Anthony Fauci over funding of bat-virus research by the National Institutes of Health. >>️

<< The NIH has still not fully explained its decision-making and did not reply to questions. Citing a pending investigation, it has declined to release copies of the grant that sent the Wuhan institute about $600,000 between 2014 and 2019. It has also revealed little about its new system for assessing gain-of-function risks, which is carried out by an anonymous review panel whose deliberations are not made public. >>️
️
Rowan Jacobsen. Inside the risky bat-virus engineering that links America to Wuhan. China emulated US techniques to construct novel coronaviruses in unsafe conditions. MIT TechRev. Jun 29, 2021. 


Also

<< " ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 4, 2008. (quasi-stochastic poetry)


<< in attesa del beffardo tsunami. >> in: 1619 - onda di carambola. Notes. Nov 29, 2004. (quasi-stochastic poetry).
️

keyword 'virus' in Notes (quasi-stochastic poetry)


keyword 'virus' in FonT 


keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)



FonT

no surprise, no amazement here, I know chickens behaviors. 

<< Ricordo che quando si era ragazzi, negli anni sessanta, ... >> in: 2157 - il pino di takata matsubara. Apr 1, 2011. Notes. 








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martedì 27 luglio 2021

# life: they ( NIH, Ralph Baric’s Univ.of North Carolina lab, Wuhan Instit.of Virology ) never created a supervirus, anzicheforse ...

<< 
In May, the coronavirus researcher Ralph Baric found himself at the center of the debate over gain-of-function research ( https://www.technologyreview.com/2021/06/29/1027290/gain-of-function-risky-bat-virus-engineering-links-america-to-wuhan ), in which scientists engineer new properties into existing viruses. And during a congressional hearing, Senator Rand Paul implied that the National Institutes of Health had been funding such research at both the Wuhan Institute of Virology and Baric’s University of North Carolina lab, and that the two labs had been collaborating to make “superviruses”. Baric released a statement clarifying the research in question did not qualify as gain-of-function, and none of the SARS-like coronaviruses he’d used in the experiments were closely related to SARS-CoV-2, yet that did little to quell questions about the role his research may have played in furthering scientists’ ability to modify coronaviruses in potentially dangerous ways. Baric believes such research is essential to the development of vaccines and other countermeasures against emerging viruses, a project he has been engaged in for more than 20 years. His research laid the groundwork for the first approved anti-covid drug and helped speed the development of the mRNA vaccines that have proved so pivotal. 
MIT Technology Review recently asked Baric to explain what constitutes a gain-of-function experiment, why such research exists, and whether it could have played any role in the pandemic. Read the full interview. ( https://www.technologyreview.com/2021/07/26/1030043/gain-of-function-research-coronavirus-ralph-baric-vaccines )
>>️

Rowan Jacobsen. Why researchers need to tinker with viruses. The Download from MIT Technology Review newsletters@technologyreview.com  
The Download from MIT (mail). Jun 26, 2021 14:12

Also

<< ... e Da-Li' si sparse pell' aere un fantasmatico ente supersintetico supercompresso ... >> in: ️2153 - cracker tendenziali (around a matter-sucking maelstrom). Notes. Apr 04, 2008. (quasi-stochastic poetry)


keyword 'virus' in Notes (quasi-stochastic poetry)


keyword 'virus' in FonT 




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sabato 17 aprile 2021

# life: apropos of '1or2achoos' (from Wuhan), 'Shame on us', by Jay.

<< The year 2003 was an ominous one for emerging infectious diseases. A pair of deadly influenza strains had leapt from birds to humans in Hong Kong and the Netherlands. And a new coronavirus was spreading around the world causing a mysterious illness that became known as severe acute respiratory syndrome, or SARS. Many experts feared they were watching the start of a global pandemic. Fortunately, the worst-case scenario never materialized. But it was a close-enough call for Robert Webster, a leading authority on avian influenza, to start urging scientists and policymakers to prepare for the next outbreak. One of his top recommendations: develop and stockpile drugs that target a wide range of viral pathogens. Drug researchers did not heed his call. After the SARS threat subsided, interest evaporated — and the world paid the price. “The scientific community really should have developed universal antivirals against SARS,” says Webster, now an emeritus member of St Jude Children’s Research Hospital in Memphis, Tennessee. “Then we would have had something in the stockpile for the emergence of COVID,” which is a caused by SARS-CoV-2, a close relative of the virus responsible for SARS. Another warning shot came in 2012, when Middle East respiratory syndrome (MERS) — caused by another relative of SARS-CoV-2 — started spreading through a handful of countries. Still, the drug shelves remained largely bare — a fact that Jay Bradner, president of the Novartis Institutes for BioMedical Research in Cambridge, Massachusetts, regards as “regrettable”. >>️

<< Shame on us, (..) We can be better prepared. >> Jay Bradner.️

<< We need an arsenal, >> Kara Carter.

<< It’s hard to convince a company to make a drug against something that doesn’t exist. >>️  Timothy Sheahan.

<< There’s a lot of work that needs to be done, (..) We don’t want to have another year like 2020, (..) and we don’t have to, if we do the work in advance. >> Nat Moorman.️
️
Elie Dolgin. The race for antiviral drugs to beat COVID — and the next pandemic. Despite dire warnings, a stockpile of ready compounds to fight viral pandemics was sorely lacking. Can drugmakers finally do the right thing? Nature 592, 340-343. doi: 10.1038/ d41586-021-00958-4. Apr 14, 2021. 


Also

keyword 'virus' | 'sars-cov-2' in FonT: 



keyword 'virus' in Notes (quasi-stochastic poetry):


apropos of "herd immunity" ... , FonT,  Mar 16, 2020.





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mercoledì 24 marzo 2021

# life: a tiny pill against two unfavorable hypotheses on serial coronavirus pandemics - to avoid the socio-economic psycho-behavioral fallout caused by 1or2achoos (e.g. from Wuhan)

<< Pfizer Inc. said it has begun human safety testing of a new pill to treat the coronavirus that could be used at the first sign of illness. If it succeeds in trials, the pill could be prescribed early in an infection to block viral replication before patients get very sick. The drug binds to an enzyme called a protease (Pfizer’s oral protease inhibitor, code-named PF-07321332,) to keep the virus from replicating. >>

<< In lab tests, it worked against many coronaviruses, including the original SARS virus and MERS. Additionally, the coronavirus protease doesn’t mutate much, which means the therapy is likely to work equally well against numerous variant strains, >>
️
<< This is really a potential game changer, >>️  Mikael Dolsten️

Robert Langreth. Pfizer Begins Human Trials of New Pill to Treat Coronavirus. 
Mar 23, 2021 17:38 CET. 


Christie Aschwanden. Five reasons why COVID herd immunity is probably impossible. Nature 591, 520-522. doi: 10.1038/ d41586-021-00728-2. Mar 18, 2021. 


Angela L. Rasmussen, Saskia V. Popescu. SARS-CoV-2 transmission without symptoms.  Science, 2021; 371 (6535): 1206-1207 doi: 10.1126/ science.abf9569   


Also

keyword 'virus' in FonT: 


keyword 'virus' in Notes (quasi-stochastic poetry):



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