# brain: flies, mice and humans, comparable behaviors for balance and motor control

<< Comparative developmental genetics indicate insect and mammalian forebrains form and function in comparable ways. However, these data are open to opposing interpretations that advocate either a single origin of the brain and its adaptive modification during animal evolution; or multiple, independent origins of the many different brains present in extant Bilateria. Here, (AA) describe conserved regulatory elements that mediate the spatiotemporal expression of developmental control genes directing the formation and function of midbrain circuits in flies, mice, and humans. These circuits develop from corresponding midbrain-hindbrain boundary regions and regulate comparable behaviors for balance and motor control. (They) findings suggest that conserved regulatory mechanisms specify cephalic circuits for sensory integration and coordinated behavior common to all animals that possess a brain. >>

Jessika C. Bridi, Zoe N. Ludlow, et al. Ancestral regulatory mechanisms specify conserved midbrain circuitry in arthropods and vertebrates. PNAS. doi: 10.1073/ pnas.1918797117. Aug 3, 2020.

https://www.pnas.org/content/early/2020/07/31/1918797117  

Humans and flies employ very similar mechanisms for brain development and function. King's College London.  Aug 3, 2020.

https://phys.org/news/2020-08-humans-flies-similar-mechanisms-brain.html

Also

'mosca in bottiglia' in: 2066 - voli a casaccio. Notes. Oct 01, 2006.   (quasi-stochastic poetry)

https://inkpi.blogspot.com/2006/10/2066-voli-casaccio.html

Also

keyword 'flies' in FonT

https://flashontrack.blogspot.com/search?q=flies

# behav: persistent neuronal firing during flight in flies, like a pulsating gambler who has to decide quickly

<< A general principle of sensory systems is that they adapt to prolonged stimulation by reducing their response over time. >>

<< as opposed to most sensory and visual neurons, and in particular to the motion vision sensitive neurons in the brains of both flies and mammals, the descending neurons show little adaption during stimulus motion. (..) the optic-flow-sensitive descending neurons display persistent firing, or an after-effect, following the cessation of visual stimulation, consistent with the lingering calcium signal hypothesis. >>

AA results << show a combination of adaptation and persistent firing in the neurons that project to the thoracic ganglia and thereby control behavioral output. >>

Sarah Nicholas, Karin Nordstrom. Persistent Firing and Adaptation in Optic-Flow-Sensitive Descending Neurons. Curr Biol. doi: 10.1016/ j.cub.2020.05.019. May 28, 2020.

https://www.cell.com/current-biology/fulltext/S0960-9822(20)30658-8

Revealing how flies make decisions on the fly to survive. Flinders University. May 28, 2020

https://phys.org/news/2020-05-revealing-flies-decisions-survive.html

Also

the flexible mental maps of flies. FonT. Nov 21, 2019. 

https://flashontrack.blogspot.com/2019/11/brain-flexible-mental-maps-of-flies.html

<< Considerando invece l' immagine classica della "mosca nella bottiglia", >>  in: 2066 - voli a casaccio. Notes. (quasi-stochastic poetry). Oct 01, 2006.

https://inkpi.blogspot.com/2006/10/2066-voli-casaccio.html

# behav: the smart sleep of flies (Drosophila melanogaster)

<< Flies that cannot take to the air respond by sleeping more as they learn to adapt to their flightlessness, (..) The findings, (..) suggest that sleep may be an evolutionary tool that helps animals adapt to challenging new situations. >>

<< Fruit flies' sleep looks a lot like people's. Baby flies need a lot of sleep, but as they get older, their need for sleep diminishes. Flies become more alert with caffeine and drowsier with antihistamines. And if you keep a fly awake one day, it will sleep more the next. >>

Flies sleep when need arises to adapt to new situations. Washington University School of Medicine. May 8, 2020.

https://phys.org/news/2020-05-flies-situations.html

K. Melnattur, B. Zhang, P. J. Shaw. Disrupting flight increases sleep and identifies a novel sleep-promoting pathway in Drosophila. Sci Adv 

Vol. 6, no. 19, eaaz2166. doi: 10.1126/sciadv.aaz2166. May 8, 2020.

https://advances.sciencemag.org/content/6/19/eaaz2166.full

Also

keyword 'Drosophila' in FonT

https://flashontrack.blogspot.com/search?q=drosophila

keyword 'mosca' in Notes (quasi- stochastic poetry)

https://inkpi.blogspot.com/search?q=mosca