# gst: stitch together at both ends to selective formation of classes of bicyclic medium-sized ring compounds

AA << have discovered catalyst-controlled divergent reactions to synthesize three different classes of medium-sized bicyclic compounds from the same starting materials  >>

<< Intermolecular higher-order cycloaddition, in which two starting materials are 'stitched' together at both ends, provides great potential to build complex cyclic compounds from simple building blocks. Unfortunately, such transformations to prepare medium-sized rings are often plagued with competitive reaction pathways and low levels of site- and stereo-selectivity >>

<< The most significant aspect of this chemistry was that not one, but three different classes of bicyclic medium-sized ring compounds were obtained with high efficiency and stereo-selectivity from the same set of starting molecules.  >>

Divergent synthesis of bicyclic medium-sized ring structures. National University of Singapore. Oct 26, 2020.

https://phys.org/news/2020-10-divergent-synthesis-bicyclic-medium-sized.html

Li-Cheng Yang, Ya-Nong Wang, et al. Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions. Nat. Chem. 12, 860–868. doi: 10.1038/ s41557-020-0503-7. July 27, 2020. 

https://www.nature.com/articles/s41557-020-0503-7

# life: aprops of 1or2 achoo! from Wuhan (SARS-CoV-2), a mask build of 'nanofibers randomly land on a collector to create a sort of non-woven mesh'

<< Recently, students from BYU’s College of Engineering teamed up with Nanos Foundation to develop a nanofiber membrane that can be sandwiched between the cloth pieces in a homemade mask. While today’s typical cloth mask might block fewer than 50% of virus particles, the membrane — which can be made using simple, inexpensive materials — will be able to block 90 to 99% of particles, increasing effectiveness while preserving breathability. The membranes are made through a process called “electrospinning,” which involves dissolving a polymer plastic in a solution and then using an electrical current to move a droplet of the polymer downward through a needle. As the droplet accelerates, it stretches into a very small fiber that retains a static charge. >>

<< Those nanofibers randomly land on a collector to create a sort of non-woven mesh, >> Katie Varela.

Christie Allen. With innovative nanofiber membranes, cloth masks’  efficacy goes up to 99%. Oct 21, 2020.

https://news.byu.edu/intellect/with-new-byu-created-nanofiber-membranes-cloth-masks-efficacy-goes-up-to-99 

https://phys.org/news/2020-10-nanofiber-membranes-masks-efficacy.html   

Also

keyword 'virus' in FonT: 

https://flashontrack.blogspot.com/search?q=virus

keyword 'virus' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=virus

# astro: the effect of Yarkovsky acceleration to direct the asteroid Apophis (towards us, hypothetically)

<< A University of Hawai Institute for Astronomy (IfA) astronomer has revealed critical new findings linked to a large asteroid expected to pass extremely close to Earth. Dave Tholen and collaborators have announced the detection of Yarkovsky acceleration on the near-Earth asteroid Apophis. This acceleration arises from an extremely weak force on an object due to non-uniform thermal radiation. This force is particularly important for the asteroid Apophis, as it affects the probability of an Earth impact in 2068. >>

Massive asteroid subject of new findings. Oct 26, 2020. 

https://www.hawaii.edu/news/2020/10/26/new-massive-asteroid-findings

"2068" –Massive Asteroid Apophis on Path for Earth Impact. Oct 27, 2020.

https://dailygalaxy.com/2020/10/2068-massive-asteroid-apophis-on-path-for-earth-impact

Also

il ciottolo Apophis. Notes. May 05, 2006 (quasi-stochastic poetry). 

https://inkpi.blogspot.com/2006/05/2001-il-ciottolo-apophis.html

A wicked list in the dino-killing range; waiting for new entries. FonT. Jun 29, 2017. 

https://flashontrack.blogspot.com/2017/06/s-astro-wicked-list-in-dino-killing.html

A few hints of our presence. Notes. Oct 13, 2006 (quasi-stochastic poetry)

https://inkpi.blogspot.com/2006/10/2073-few-hints-of-our-presence.html

# life: deliver care remotely; can we trust AI Doctors?

<< Machine learning is taking medical diagnosis by storm. From eye disease, breast and other cancers, to more amorphous neurological disorders, AI is routinely matching physician performance, if not beating them outright.  Yet how much can we take those results at face value? When it comes to life and death decisions, when can we put our full trust in enigmatic algorithms—“black boxes” that even their creators cannot fully explain or understand? The problem gets more complex as medical AI crosses multiple disciplines and developers, including both academic and industry powerhouses such as Google, Amazon, or Apple, with disparate incentives. >>

<< This week, the two sides battled it out in a heated duel in one of the most prestigious science journals, Nature. >>

Shelly Fan. Can We Trust AI Doctors? Google Health and Academics Battle It Out. Oct 20, 2020. 

https://singularityhub.com/2020/10/20/can-we-trust-ai-doctors-google-health-and-academics-battle-it-out

Benjamin Haibe-Kains, George Alexandru Adam, et al. Transparency and reproducibility in artificial intelligence. Nature 586, E14–E16.  doi: 10.1038/ s41586-020-2766-y. Oct 15, 2020

https://www.nature.com/articles/s41586-020-2766-y

Emre Sezgin, Yungui Huang, et al. Readiness for voice assistants to support healthcare delivery during a health crisis and pandemic. npj Digit. Med. 3, 122. doi: 10.1038/ s41746-020-00332-0. Sep 16, 2020.

https://www.nature.com/articles/s41746-020-00332-0

# gst: NikS, a small RNA molecule uses a sort of 'bet-hedging' strategy to survive and infect

<< More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer. Helicobacter pylori uses several 'virulence' factors that allow it to survive in the stomach and can lead to the development of disease. (AA) report that multiple of these factors are centrally regulated by a small RNA molecule called NikS.  >>

<< The fact that Helicobacter pylori can colonize such a hostile environment as the stomach so successfully is also due to a special genetic strategy: Like other pathogens, H. pylori uses a strategy known as phase variation to adapt as flexibly as possible to changes in its environment. Phase variation means that the bacteria constantly switch expression of a gene at random through genetic mutations, meaning that some bacteria in a population will always be ready to express the important gene when it becomes important—a sort of 'bet-hedging' strategy. >>

Robert Emmerich. Small RNA as a central player in infections. University of Würzburg. Oct 15, 2020. 

https://phys.org/news/2020-10-small-rna-central-player-infections.html   

Sara K. Eisenbart, Mona Alzheimer, et al. A Repeat-Associated Small RNA Controls the Major Virulence Factors of Helicobacter pylori. Mol Cell. vol 80, issue 2, P210-226.E7. doi: 10.1016/ j.molcel.2020.09.009. Oct 15, 2020. 

https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30617-1

# ai-bot: use of soft labels with 'less than one'-shot task in AI learning models

<< Deep neural networks require large training sets but suffer from high computational cost and long training times. Training on much smaller training sets while maintaining nearly the same accuracy would be very beneficial. In the few-shot learning setting, a model must learn a new class given only a small number of samples from that class. One-shot learning is an extreme form of few-shot learning where the model must learn a new class from a single example. (AA)  propose the 'less than one'-shot learning task where models must learn N new classes given only M<N examples and (they) show that this is achievable with the help of soft labels. >>

Ilia Sucholutsky, Matthias Schonlau. 'Less Than One'-Shot Learning: Learning N Classes From M<N Samples. arXiv:2009.08449v1. Sep 17, 2020

https://arxiv.org/abs/2009.08449   

Karen Hao. A radical new technique lets AI learn with practically no data. Oct 16, 2020.  

https://www.technologyreview.com/2020/10/16/1010566/ai-machine-learning-with-tiny-data

FonT: sara' verosimilmente intrigante osservare come una 'macchina AI' sapra' esercitare sugli umani il potere di cooptazione ...

# chem: choose a molecule from an online 'Spotify' for chemistry and synthesize it with a desktop-sized bot

AA << have found a way to create new sets of instructions for robot chemists by harnessing the power of natural language processing. They developed a computer program called SynthReader to scan through scientific papers and recognize sections which outline procedures for organic and inorganic chemical synthesis. Synthreader automatically breaks those procedures down to simple instructions and stores them in a format the team call Chemical Description Language, or XDL, which is a new open source language for describing chemical and material synthesis. Those XDL files are chemical instructions which can in principle be read any chemical robot in. The team built an easy-to-use interface called ChemIDE to integrate with any robotic chemist system and allow the XDL instructions to be turned into chemicals. The only human input required is ensuring that the equipment the robot needs to make the molecules is set up correctly. >>

'Digital chemistry' breakthrough turns words into molecules. University of Glasgow. Oct 2, 2020. 

https://phys.org/news/2020-10-digital-chemistry-breakthrough-words-molecules.html   

S. Hessam M. Mehr, Matthew Craven, et al. A universal system for digitization and automatic execution of the chemical synthesis literature. Science. Vol. 370, Issue 6512, pp. 101-108. doi: 10.1126/ science.abc2986. Oct 2, 2020.

https://science.sciencemag.org/content/370/6512/101