# gst: intrinsic disorder bars intruders (from biomolecular condensates)

<< It was recently discovered that eukaryotic cells are host to a multiplicity of biomolecular condensates. These condensates typically contain protein and/or RNA components with intrinsically disordered regions (IDRs). While IDRs have been proposed and demonstrated to play many roles in condensate biology, (AA) suggest here an additional crucial role of IDRs, which is to exclude unwanted “intruders” from condensates. This exclusion effect arises from the large conformational entropy of IDRs; i.e., there is a high free-energy cost to occupying space that would otherwise be available to the IDRs. By combining polymer theory with sticker-spacer simulations, (They) show that the relevant insertion free energy increases with the concentration of IDRs in the condensate as well as with intruder size, attaining a linear scaling with surface area for large intruders. >>

AA << find that at realistic IDR concentrations, particles as small as the size of an average protein (4 nm in diameter) can be 97% excluded from condensates. To overcome this entropic barrier, molecules must interact favorably with condensate components to be recruited as clients. Application of the developed size-exclusion theory to biological condensates suggests that condensate IDRs may play a generic exclusionary role across organisms and types of condensates. >>️

Vladimir Grigorev, Ned S. Wingreen, Yaojun Zhang. Conformational Entropy of Intrinsically Disordered Proteins Bars Intruders from Biomolecular Condensates. PRX Life 3, 013011. Feb 14, 2025.

https://journals.aps.org/prxlife/abstract/10.1103/PRXLife.3.013011

Also: order, disorder, disorder & fluctuations, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, order, disorder, disorder & fluctuations, transitions

# gst: necklacelike pattern of vortex bound states

<< A vortex is a topological defect in the superconducting condensate when a magnetic field is applied to a type-II superconductor, (..). Because of the confinement of the quasiparticles by a vortex, it exhibits a circular-shaped pattern of bound states with discrete energy levels, (..) >>

 Here, AA << report a completely new type of vortex pattern which is necklacelike in an iron-based superconductor (..). (AA) theoretical analysis shows that this necklacelike vortex pattern arises primarily from selective off-shell interference between vortex bound states of opposite angular momenta in the presence of rotational symmetry breaking due to disorders. >>

<< This fascinating effect can be observed in a system with a small Fermi energy and wave vector, conditions fortuitously met in (Their) samples. (AA) results not only disclose a novel vortex structure, but also unravel a completely new quantum phenomenon in the superconducting condensate. >>️

Zhiyong Hou, Kailun Chen, et al. Necklacelike Pattern of Vortex Bound States. Phys. Rev. X 15, 011027. Feb 7, 2025.   https://journals.aps.org/prx/abstract/10.1103/PhysRevX.15.011027   arXiv: 2407.08547v1 [cond-mat.supr-con]. Jul 11, 2024.    https://arxiv.org/abs/2407.08547

Also: vortex, disorder, disorder & fluctuations, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, vortex, vortex bound states, symmetry breaking, disorder, disorder & fluctuations, necklacelike patterns

# gst: apropos of subdiffusive behaviors, the boomerang effect in classical stochastic models.

<< The phenomenon of Anderson localization, occurring in a disordered medium, significantly influences the dynamics of quantum particles. A fascinating manifestation of this is the “quantum boomerang effect” (QBE), observed when a quantum particle, propelled with a finite initial velocity, reverses its average trajectory, eventually halting at its starting point. >>

AA << uncover evidence of a similar effect in classical systems, characterized by the absence of typical diffusion processes. (Their) investigation encompasses both simplified probabilistic models and more complex phenomenological models that link classical with quantum mechanics. The results indicate that the boomerang effect is not confined to the quantum realm and may also be present in diverse systems exhibiting subdiffusive behavior. >>️

Santiago Zamora, Lisan M. M. Durao, et al. Boomerang effect in classical stochastic models. Phys. Rev. E 111, 024104. Feb 3, 2025.

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.111.024104 

Also: behav, particle, disorder, disorder & fluctuations, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, behavior, particles, disorder, disorder & fluctuations, stocasticity, boomerang effect

# gst: criticality and multistability in quasi-2D turbulence

       Fig. 1(a) Helmholtz resonators

<< Two-dimensional (2D) turbulence, despite being an idealization of real flows, is of fundamental interest as a model of the spontaneous emergence of order from chaotic flows. The emergence of order often displays critical behavior, whose study is hindered by the long spatial and temporal scales involved. >>

Here AA << experimentally study turbulence in periodically driven nanofluidic channels with a high aspect ratio using superfluid helium. (They) find a multistable transition behavior resulting from cascading bifurcations of large-scale vorticity and critical behavior at the transition to quasi-2D turbulence consistent with phase transitions in periodically driven many-body systems. >>

AA << demonstrate that quasi-2D turbulent systems can undergo an abrupt change in response to a small change in a control parameter, consistent with predictions for large-scale atmospheric or oceanic flows. >>️

Filip Novotny, Marek Talir, et al. Critical behavior and multistability in quasi-two-dimensional turbulence. arXiv: 2406.08566v1 [physics.flu-dyn]. Jun 12, 2024.

https://arxiv.org/abs/2406.08566

Also: order, disorder, disorder & fluctuations, turbulence, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, order, disorder, disorder & fluctuations, criticality, turbulence, transition