# life: a new exception within the FDA Cures Act Informed Consent, the intriguing concept of 'Minimal Risk Clinical Investigations'.

<< The Food and Drug Administration (FDA, the Agency, or we) is issuing a final rule to amend its regulations to implement a provision of the 21st Century Cures Act (Cures Act). This final rule allows an exception from the requirement to obtain informed consent when a clinical investigation poses no more than minimal risk to the human subject and includes appropriate safeguards to protect the rights, safety, and welfare of human subjects. The final rule permits an institutional review board (IRB) to waive or alter certain informed consent elements or to waive the requirement to obtain informed consent, under limited conditions, for certain FDA-regulated minimal risk clinical investigations. >>️

Institutional Review Board Waiver or Alteration of Informed Consent for Minimal Risk Clinical Investigations. A Rule by the Food and Drug Administration on 12/21/2023. federalregister.gov 

https://www.federalregister.gov/documents/2023/12/21/2023-27935/institutional-review-board-waiver-or-alteration-of-informed-consent-for-minimal-risk-clinical

FonT:  'Minimal Risk Clinical Investigations (MRCI)': here are intriguing both (i) the scientific formalization of the operational methods decided (case by case) by the FDA about MRCI and (ii) the possible strategies - if at least one exists - for avoiding the 'multitude of unaware' from this type of interception.

Also: Are you ready for all this?, in https://www.inkgmr.net/kwrds.html

Also: evitare (avoid), in Notes (quasi-stochastic poetry)  https://inkpi.blogspot.com/search?q=evitare

Also: avoid, in FonT https://flashontrack.blogspot.com/search?q=avoid

Also: Robert F. Kennedy's opinion on the issue https://twitter.com/RobertKennedyJr/status/1752126207821271080  

Keywords: life, FDA, informed consent, risk, minimal risk, minimal risk clinical investigations, avoidance, 1or2achoos, are you ready

# gst: analogy between quasi-2D and 3D liquid drops.

<< Liquid drops are everywhere around us and important in numerous technological applications. Here, (AA) demonstrate a quasi-two-dimensional (Q2D) analogy to the regular, often close to axisymmetric, three-dimensional (3D) drops. >>️

<< The Q2D drops are created by confining liquids between vertical walls, leading to formation of low aspect ratio capillary bridges that are deformed by gravity. When stationary, the Q2D drops adopt projected shapes that are analogous to 3D sessile drops, ranging from circular drops to puddles. >>️

<< When moving, the Q2D drops exhibit capillary and fluid mechanical behaviours analogous to 3D drops, including impacts and sliding on pseudo-surfaces. The Q2D drops also exhibit considerably more complex phenomena such as levitation, instabilities and pattern formation when subjected to external electric, magnetic and flow fields -- all seen also in regular 3D drops. >>️

<< 3D-Q2D analogy suggests that the diverse and often complicated phenomena observed in 3D drops can be studied in the Q2D geometry, >>

️

Tytti Kärki, Into Pääkkönen, et al. Quasi-Two-Dimensional Drops. arXiv: 2401.11845v1 [physics.flu-dyn]. Jan 22, 2024.

https://arxiv.org/abs/2401.11845

Also: drop, analogy, in https://www.inkgmr.net/kwrds.html

Keywords: gst, drop, droplet, droploid, analogy

# gst: intertwining order, disorder, and hierarchy

<< Nature hosts a wealth of materials showcasing intricate structures intertwining order, disorder, and hierarchy, delivering resilient multifunctionality surpassing perfect crystals or simplistic disordered materials. The engineering of such materials through nanoparticle assembly represents a burgeoning field, poised with potential to yield sustainable material systems rivaling or exceeding biological functionalities. >>

AA << review delineates the fundamental concept of complexity in the context of nanoscale materials. >>

Xiaoming Mao, Nicholas Kotov. Complexity, Disorder, and Functionality of Nanoscale Materials. arXiv: 2401.09567v1 [cond-mat.soft]. Jan 17, 2024. 

https://arxiv.org/abs/2401.09567

Also: nano, particle, order, disorder, in  https://www.inkgmr.net/kwrds.html

Keywords: nano, particle, order, disorder 

# gst: compression and fracture of ordered and disordered droplet rafts

AA << simulate a two-dimensional array of droplets being compressed between two walls. The droplets are adhesive due to an attractive depletion force. As one wall moves toward the other, the droplet array is compressed and eventually induced to rearrange. The rearrangement occurs via a fracture, where depletion bonds are quickly broken between a subset of droplets. >>

<< For monodisperse, hexagonally ordered droplet arrays, this fracture is preceded by a maximum force exerted on the walls, which drops rapidly after the fracture occurs. >>

<< In small droplet arrays a fracture is a single well-defined event, but for larger droplet arrays, competing fractures can be observed. These are fractures nucleated nearly simultaneously in different locations. >>

AA << also study the compression of bidisperse droplet arrays. The addition of a second droplet size further disrupts fracture events, showing differences between ideal crystalline arrays, crystalline arrays with a small number of defects, and fully amorphous arrays. >>

️

Pablo Eduardo Illing, Jean-Christophe Ono-dit-Biot, et al. Compression and fracture of ordered and disordered droplet rafts. Phys. Rev. E 109, 014610. Jan 17, 2024.

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.109.014610

Also: drop, defect, fracture, crack, in https://www.inkgmr.net/kwrds.html

Also:  raft   https://flashontrack.blogspot.com/search?q=raft  

zattera (quasi-stochastic poetry) https://inkpi.blogspot.com/2005/04/1864-onda-di-liberazione.html  

randa (quasi-stochastic poetry) https://inkpi.blogspot.com/search?q=randa

Keywords: gst, drop, droplet, raft, defect, fracture, crack

# behav: mechanics of fire ant rafts as an active self-healing membrane

<< The unique ability of fire ants to form a raft to survive flooding rain has enchanted biologists as well as researchers in other disciplines. (..) a three-dimensional aggregation of fire ants exhibits viscoelasticity with respect to external compression and shearing among numerous unusual mechanical properties. >>️

AA << study the ant raft in its natural form, i.e., composing no more than two layers. This allowed to focus on the cracks that are unique to membranes and see how their patterns are influenced by the fact that these ants are mobile and can self-repair the damage to keep their raft from disintegration. >>️

They << show that vertical and horizontal shaking can also prompt fire ants to aggregate.  (..)  the pull force expedites the alignment of fire ants, in analogy to the effect of an electric field on liquid crystal polymers. >>️

<< One major finding is that the raft can exhibit zero Poisson's ratio without resorting to specific geometry structures. This is enabled by the active recruitment of ants from the top layer to the bottom layer to keep the raft from disintegrating. >>️

️

Chung-Hao Chen, Ting-Heng Hsieh, et al. Formation and mechanics of fire ant rafts as an active self-healing membrane. Phys. Rev. E 109, 014607. Jan 9, 2024. 

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.109.014607

David Ehrenstein. Material Properties of Fire-Ant Rafts. Physics 17, s5. Jan 9. 2024. 

https://physics.aps.org/articles/v17/s5

Also:  raft   https://flashontrack.blogspot.com/search?q=raft  

zattera (quasi-stochastic poetry) https://inkpi.blogspot.com/2005/04/1864-onda-di-liberazione.html  

randa (quasi-stochastic poetry) https://inkpi.blogspot.com/search?q=randa

Also: behav, behavior, in  https://www.inkgmr.net/kwrds.html

Keywords behavior, behaviour, ant, raft, self-healing

# gst: self-repelling species could self-organize.

<< Catalytically active particles form clusters when they respond not only to their own chemical targets but to those of other catalysts, too. >>️

AA  << show that the phenomenon of self-organization depends strongly on the network topology. >>️

They << modeled a three-species system (..) systems where each species responds chemotactically only to its own substrate cannot self-organize unless one species is self-attracting. >>️

<< Next, they developed a model that allowed species to respond to both their substrates and their products. Pair interactions between different species in this more complex model drove an instability that spread throughout the three-species system, causing the catalysts to clump together. Surprisingly, this self-organization process occurred even among particles that were individually self-repelling. >>️

Rachel Berkowitz. Self-Repelling Species Still Self-Organize. Physics 16, s128. Sept 19, 2023. 

https://physics.aps.org/articles/v16/s128

Vincent Ouazan-Reboul, Ramin Golestanian, Jaime Agudo-Canalejo. Network effects lead to self-organization in metabolic cycles of self-repelling catalysts. Phys. Rev. Lett. 131, 128301. Sep 19, 2023. 

http://dx.doi.org/10.1103/PhysRevLett.131.128301

Also: self-assembly, network, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, self-assembly, network,  topology.

# gst: the hypothesis of a new type of rogue waves.

<< Much attention of researchers has been paid in the recent decades to the study of rogue waves. Various mechanisms of formation of these waves were suggested. The occurrence of rogue waves is most often investigated on the basis of the mechanisms of modulation instability and superposition of waves. In both cases, an evolution of rogue waves takes place against the background of a wave field, which is reflected in the definitions of such waves. In this report, the localized waves developed in the absence of the background wave fields are considered. At the same time, their dynamics corresponds to the dynamics of rogue waves that ”appear from nowhere and disappear without a trace”. >>️

<< The waves of this type are distinguished by the fact that their dynamics occur on the zero background. This implies that rogue waves presented here are formed solely due to the nonlinear focusing. >>️

N.V. Ustinov. New type of rogue waves. arXiv:2310.17254v1 [nlin.SI]. Oct 26, 2023.  

https://arxiv.org/abs/2310.17254

Chaos, Solitons & Fractals V. 179, Feb 2024, 114467. https://www.sciencedirect.com/science/article/abs/pii/S0960077924000183

Also: waves, in https://www.inkgmr.net/kwrds.html

Keywords: gst, waves, rogue waves