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Visualizzazione dei post in ordine di pertinenza per la query bacteria. Ordina per data Mostra tutti i post
Visualizzazione dei post in ordine di pertinenza per la query bacteria. Ordina per data Mostra tutti i post

sabato 15 dicembre 2018

# gst: the complex world of Bacteria; collective oscillations via discontinuous transitions, chemical quorum sensing and brainlike bursts of electricity to communicate.

<< collective oscillations in cell populations can emerge suddenly with nonzero amplitude via a discontinuous transition. >>

Rosa Martinez-Corral, Jintao Liu, et al. Bistable emergence of oscillations in growing Bacillus subtilis biofilms. PNAS Sep 4, 2018;  115 (36) E8333-E8340.  doi: 10.1073/pnas.1805004115

https://www.pnas.org/content/115/36/E8333 

<< As in all communities, cohabiting bacteria need ways to exchange messages. Biologists have known for decades that bacteria can use chemical cues to coordinate their behavior. >>

AA << are now finding that bacteria in biofilms can also talk to one another electrically. Biofilms appear to use electrically charged particles to organize and synchronize activities across large expanses. This electrical exchange has proved so powerful that biofilms even use it to recruit new bacteria from their surroundings, and to negotiate with neighboring biofilms for their mutual well-being. >>

<< Step by step we find that all the things we think bacteria don’t do, they actually do, [..] It’s displacing us from our pedestal. >> Ned Wingreen.

Gabriel Popkin. Bacteria Use Brainlike Bursts of Electricity to Communicate. With electrical signals, cells can organize themselves into complex societies and negotiate with other colonies. Sep 5, 2017

https://twitter.com/QuantaMagazine/status/1071417372500783104

https://www.quantamagazine.org/bacteria-use-brainlike-bursts-of-electricity-to-communicate-20170905/

Also

Gurol M. Suel publ.

http://labs.biology.ucsd.edu/suel/index.html

FonT

intrigante qui l'idea di una Intelligenza Artificiale che, dalle relativamente comode e veloci osservazioni sull'evoluzione di colonie batteriche sotto differenti condizioni, sia in grado di circoscrivere pattern comportamentali di interesse per la modellizzazione (e previsione)  di comunita' altre ...

mercoledì 6 novembre 2019

# behav: 'run and tumble' behavior (among bacteria)

<< Bacteria in groundwater move in surprising ways. They can passively ride flowing groundwater, or they can actively move on their own in what scientists call "run and tumble" behavior.  >>

AA << noted a distinct run (movement in one direction) followed by a tumble (a sudden, random change in direction). By calculating the length and timing of these movements, they could develop a simple Continuous Time Random Walk (CTRW) model to predict how the bacteria would move. When compared to current models for bacterial remediation, the CTRW model was better at predicting bacterial transport in many circumstances. The CTRW model is the first step in developing and testing new reactive transport models that incorporate bacterial transport behavior.  >>

Rishi Parashar. Calculating 'run and tumble' behavior of bacteria in groundwater. Environmental Molecular Sciences Laboratory. Oct 31, 2019. 

https://m.phys.org/news/2019-10-behavior-bacteria-groundwater.html  

Xueke Yang, Rishi Parashar, et al. On Modeling Ensemble Transport of Metal Reducing Motile Bacteria. Scientific Reports volume 9, Article number: 14638. Oct 10, 2019. 

https://www.nature.com/articles/s41598-019-51271-0

giovedì 19 ottobre 2017

# gst: cooperating vs self-serving bacteria in transitional (noise) scenarios

AA << study a well-mixed, finite population consisting of two strains competing for the limited resources provided by an environment that randomly switches between states of abundance and scarcity >>

AA << consider two scenarios—one of pure resource competition, and one in which one strain provides a public good—and investigate how environmental randomness (external noise) coupled to demographic (internal) noise determines the population’s fixation properties and size distribution >>

Karl Wienand, Erwin Frey, Mauro Mobilia. Evolution of a Fluctuating Population in a Randomly Switching Environment. Phys. Rev. Lett. 119, 158301 Oct 11, 2017

https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.119.158301

AA << showed that a randomly changing environment can create a level playing field between self-serving bacteria and bacteria that work together >>

<< Cooperating bacterial populations are more likely to survive in changing habitats >>

Fluctuating environments can help cooperating bacteria. Oct 12, 2017

https://m.phys.org/news/2017-10-fluctuating-environments-cooperating-bacteria.html

lunedì 19 agosto 2024

# gst: apropos of 'normal' (jazzy?) codes, bacteria encode hidden, free-floating genes outside their genome.

AA << show that bacteria break that rule and can create free-floating and ephemeral genes, raising the possibility that similar genes exist outside of our own genome. >>️

<< What this discovery upends is the notion that the chromosome has the complete set of instructions that cells use to produce proteins, (..) We now know that, at least in bacteria, there can be other instructions not preserved in the genome that are nonetheless essential for cell survival. (..) The DNA molecule is a fully functioning, free-floating, transient gene. >> Samuel Sternberg. 

Bacteria Encode Hidden Genes Outside Their Genome—Do We? Columbia University Irving Medical Center. Aug 8, 2024. 

Stephen Tang, Valentin Conte, et al. De novo gene synthesis by an antiviral reverse transcriptase. Science. doi: 10.1126/ science.adq0876. Aug 8, 2024. 

Also

Keywords: gst, codes, dna, rna, crispr, normal, jazz


lunedì 7 dicembre 2015

# rmx-s-behav: not to harm themselves

<< Bacteria-killing bacteria (“predatory bacteria”) (..) have been found to produce a protein “antidote” that protects them from their own weapons >>

<< Self-protection technique allows one bacterium to destroy others >>

<< Understanding how these predators attack bacteria could provide new ways of combatting antimicrobial resistance >>

http://www.bbsrc.ac.uk/news/health/2015/151202-pr-how-bacterial-predators-kill-other-bacteria/

Carey Lambert, Ian T. Cadby,  et al.  Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nature Communications, 2015; 6: 8884 DOI: 10.1038/NCOMMS9884

http://www.nature.com/ncomms/2015/151202/ncomms9884/full/ncomms9884.html

questo e' un esempio in natura dell'esistenza di sorta di "cappottino" prodotto da una entita' in grado di proteggersi dall'autolesione, dall'autopredazione.

domenica 9 gennaio 2022

# ecol: mycological jazz

<< "Mycological" draws conceptually from fungal networks in forests and their interactions. Inspired by the work of ecologist Suzanne Simard, author Michael Pollan, and mycologist Paul Stamets; Krolak saw many parallels between biological networks and the social network known as jazz, as well as, the acoustic networks created when musicians interact through their instruments. Aesthetically, the work is of the free and avant-garde traditions of jazz. Drawing inspiration from John Coltrane to Sonny Sharrock to Makaya McCraven, Krolak seeks to create a space for various elements to play out and find their own connections. >>

Mycological By Nicholas Krolak. All About Jazz. Jan 8, 2022. 


Also

Apropos of 'mycological jazz', a old  perplexity of mine, who knows why substantial funds were no longer allocated to sci research on viruses, bacteria, fungi (..) and their ecological 'jazzy interactions' ... ? 😏

keyword 'virus' | 'bacteria' | 'fungi' in FonT




Also

Much of intelligence (quasi-stochastic poetry). Notes. Dec 16, 2005.


keyword 'jazz' in FonT


keyword 'jazz' in Notes (quasi-stochastic poetry):


Keywords: jazz, viruses, bacteria, fungi, interactions, acad, scires, funds


venerdì 11 dicembre 2015

# rmx-s-behav: cooperative vs. opportunistic bacteria

<< bacteria, which do not actively contribute to metabolite production, can be excluded from the cooperative benefits. The research team demonstrated that cooperative cross-feeding interactions that grow on two-dimensional surfaces are protected from being exploited by opportunistic, non-cooperating bacteria. Under these conditions, non-cooperating bacteria are spatially excluded from the exchanged amino acids. This protective effect probably stabilizes cooperative cross-feeding interactions in the long-run. >>

http://www.ice.mpg.de/ext/1243.html

Samay Pande, Filip Kaftan, et al. Privatization of cooperative benefits stabilizes mutualistic cross-feeding interactions in spatially structured environments. The ISME Journal, 2015; DOI: 10.1038/ismej.2015.212

http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2015212a.html

venerdì 11 ottobre 2024

# evol: flip of the script when an entity invert code sequences

<< Jekyll and Hyde flip of the script when bacteria invert gene sequences. If a cell can diversify its own genome, this can be advantageous in the face of changing environmental conditions. Bacteria have been found that can alter encoded proteins by using the trick of sequence inversion inside genes. >>️

Chia-Chi Chang, Robert R. Jenq. Jekyll and Hyde flip of the script when bacteria invert gene sequences. Nature 634, 42-43. Sep 25, 2024. 

Chia-Chi Chang, Robert R. Jenq. Bacteria invert gene sequences to flip the script. Nature. Vol 634. Oct 3, 2024 (pdf)  https://media.nature.com/original/magazine-assets/d41586-024-02807-6/d41586-024-02807-6.pdf

Chanin RB, West PT, et al. Intragenic DNA inversions expand bacterial coding capacity. Nature. 2024 Oct; 634 (8032): 234-242. doi: 10.1038/s41586-024-07970-4. Sep 25, 2024. 

Also: evolution,  in https://www.inkgmr.net/kwrds.html 

Also

Also (quasi-stochastic poetry): 

Keywords: evolution, codes, DNA, RNA


venerdì 25 marzo 2016

# s-gene-biotech: the first designer minimal cell JCVI-syn3.0

<< "It doesn’t do anything magical rather than live, eat, and self-replicate,” Venter [@JCVenter]  says. But it is, he says, “the first designer organism in history" >>

Matthew Herper. After 20 Year Quest, Biologists Create Synthetic Bacteria With No Extra Genes. Mar 24, 2016 02:00 PM

http://www.forbes.com/sites/matthewherper/2016/03/24/bio-maverick-craig-venter-hacks-bacteria-to-have-tiniest-possible-genetic-code/

<<  JCVI-syn3.0 is a working approximation of a minimal cellular genome, a compromise between small genome size and a workable growth rate for an experimental organism. It retains almost all the genes that are involved in the synthesis and processing of macromolecules. Unexpectedly, it also contains 149 genes with unknown biological functions, suggesting the presence of undiscovered functions that are essential for life. >>

Clyde A. Hutchison III, Ray-Yuan Chuang, et al. Design and synthesis of a minimal bacterial genome. Science  25 Mar 2016: Vol. 351, Issue 6280, DOI: 10.1126/science.aad6253

http://science.sciencemag.org/content/351/6280/aad6253

venerdì 16 febbraio 2018

# epidem: they fall from the sky

<< Aerosolization of soil-dust and organic aggregates in sea spray facilitates the long-range transport of bacteria, and likely viruses across the free atmosphere. >>

The << results provide an explanation for enigmatic observations that viruses with very high genetic identity can be found in very distant and different environments. >>

Isabel Reche, Gaetano D’Orta, et al. Deposition rates of viruses and bacteria above the atmospheric boundary layer. The ISME Journal.
doi: 10.1038/s41396-017-0042-4. Jan 29,  2018.

https://www.nature.com/articles/s41396-017-0042-4

University of British Columbia.  Viruses - lots of them - are falling from the sky. Feb 6, 2018.

https://m.phys.org/news/2018-02-viruseslots-themare-falling-sky.html

giovedì 30 novembre 2023

# gene: bacteria and archaea CRISPR everywhere in nature

<< Single-celled bacteria and archaea use CRISPR systems to defend themselves against viruses known as bacteriophages. (..) Until now, researchers had identified six types of CRISPR system, designated I–VI. >>

AA << developed an algorithm called FLSHclust, which analyses genetic sequences in public databases. (..) By looking at the predicted function of the clusters, the researchers found around 130,000 genes associated in some way with CRISPR, 188 of which had never been seen before, >>️️

<< It’s a treasure trove for biochemists, >> Lennart Randau.

Sara Reardon. ‘Treasure trove’ of new CRISPR systems holds promise for genome editing. Nature. doi: 10.1038/ d41586-023-03697-w. Nov 23, 2023. 

Han Altae-Tran, Soumya Kannan, Feng Zhang, et al. Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. 
Science, Vol 382, Issue 6673. doi: 10.1126/ science.adi1910. Nov 23, 2023. 


Keywords: genome, gene, crispr, crispr system, ai, artificial intelligence


venerdì 26 marzo 2021

# evol: ancient photosynthesis could be as old as life itself

<< the earliest bacteria had the tools to perform a crucial step in photosynthesis,  (..) The finding also challenges expectations for how life might have evolved on other planets. >>️

<< Photosystem II show patterns of evolution that are usually only attributed to the oldest known enzymes, which were crucial for life itself to evolve >> Tanai Cardona.️

<< enzymes capable of performing the key process in oxygenic photosynthesis -- splitting water into hydrogen and oxygen -- could actually have been present in some of the earliest bacteria. The earliest evidence for life on Earth is over 3.4 billion years old and some studies have suggested that the earliest life could well be older than 4.0 billion years old.  Like the evolution of the eye, the first version of oxygenic photosynthesis may have been very simple and inefficient; as the earliest eyes sensed only light, the earliest photosynthesis may have been very inefficient and slow. (..) that oxygen production was present at all so early on means in other environments, such as on other planets, the transition to complex life could have taken much less time. >>️

Photosynthesis could be as old as life itself. Imperial College London. Mar 24, 2021. 


Thomas Olivera, Patricia Sanchez-Baracaldo, et al. Time-resolved comparative molecular evolution of oxygenic photosynthesis.Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2021; 1862 (6): 148400. doi: 10.1016/ j.bbabio.2021.148400. Jun 1,  2021.


Also

Lewis M. Ward, Patrick M. Shih. Granick revisited: Synthesizing evolutionary and ecological evidence for the late origin of bacteriochlorophyll via ghost  lineages and horizontal gene transfer. PLoS ONE 16(1): e0239248. doi:10.1371/journal.pone.0239248. 
Jan 28, 2021. 



domenica 25 ottobre 2020

# gst: NikS, a small RNA molecule uses a sort of 'bet-hedging' strategy to survive and infect

<< More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer. Helicobacter pylori uses several 'virulence' factors that allow it to survive in the stomach and can lead to the development of disease. (AA) report that multiple of these factors are centrally regulated by a small RNA molecule called NikS.  >>

<< The fact that Helicobacter pylori can colonize such a hostile environment as the stomach so successfully is also due to a special genetic strategy: Like other pathogens, H. pylori uses a strategy known as phase variation to adapt as flexibly as possible to changes in its environment. Phase variation means that the bacteria constantly switch expression of a gene at random through genetic mutations, meaning that some bacteria in a population will always be ready to express the important gene when it becomes important—a sort of 'bet-hedging' strategy. >>

Robert Emmerich. Small RNA as a central player in infections. University of Würzburg. Oct 15, 2020. 


Sara K. Eisenbart, Mona Alzheimer, et al. A Repeat-Associated Small RNA Controls the Major Virulence Factors of Helicobacter pylori. Mol Cell. vol 80, issue 2, P210-226.E7. doi: 10.1016/ j.molcel.2020.09.009. Oct 15, 2020. 



giovedì 21 luglio 2016

# s-evol: swapping analogous genes among species

<< (..) about half of shared genes are interchangeable across species. >>

<< (..)  in unpublished experiments, the researchers have swapped yeast genes with analogous ones from Escherichia coli bacteria or with those from the plant Arabidopsis thaliana >>

<< About 60 percent of E. coli genes could stand in for their yeast counterparts >>

Tina Hesman Saey. Swapping  analogous  genes  no  problem  among  species. Yeast  survives  with  bacteria,  plant,  human  versions  of shared  genetic  material. July 19, 2016, 4:12pm.

https://www.sciencenews.org/article/swapping-analogous-genes-no-problem-among-species

Aashiq H. Kachroo et al. Deciphering common principles governing gene replaceability in yeast. The Allied Genetics Conference 2016, Orlando, Fla., July 15, 2016.

http://www.genetics2016.org/presenters/abstracts

venerdì 29 marzo 2019

# gst: programmed cell death (apoptosis) also in algae

<< bacteria that live on single-cellular algae can cause programmed cell death. "It is the first documentation of true apoptosis via bacterial pathogens in microorganisms like algae," >>  Rebecca Case.

Study shows first evidence bacterial-induced apoptosis in algae. University of Alberta.  Mar 21, 2019.

https://m.phys.org/news/2019-03-evidence-bacterial-induced-apoptosis-algae.html    

Anna R. Bramucci, Rebecca J. Case.
Phaeobacter inhibens induces apoptosis-like programmed cell death in calcifying Emiliania huxleyi. Scientific Reports. Volume 9, Article number: 5215 (2019) March 21.

https://www.nature.com/articles/s41598-018-36847-6  

domenica 13 dicembre 2015

# s-lab: rapid detection of biomarkers: birefringence

<< (..) a new diagnostic method. It is based on Birefringence, the ability of substances to change the polarisation state of light. With this method, doctors around the world can easily, rapidly and reliably detect malaria, Ebola or HIV to name only a few >>

https://www.ethz.ch/en/news-and-events/eth-news/news/2015/12/diagnostics-with-birefringence.html

Jijo J. Vallooran, Stephan Handschin, et al. Lipidic Cubic Phases as a Versatile Platform for the Rapid Detection of Biomarkers, Viruses, Bacteria, and Parasites. Advanced Functional Materials, 2015, December 4; DOI: 10.1002/adfm.201503428

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201503428/abstract

lunedì 8 aprile 2019

# epidem: silent invasions, the case of Candida auris.

<< Bacteria are rebelling  >>

<< The germ, a fungus called Candida auris, preys on people with weakened immune systems, and it is quietly spreading across the globe. >>

Matt Richtel,  Andrew Jacobs. DEADLY GERMS, LOST CURES. A Mysterious Infection, Spanning the Globe in a Climate of Secrecy. The rise of Candida auris embodies a serious and growing public health threat: drug-resistant germs. NYT. April 6, 2019.

https://www.nytimes.com/2019/04/06/health/drug-resistant-candida-auris.html

<< The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. >>

Matthew C. Fisher, Nichola J. Hawkins, et al.  Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science  May 18, 2018
Vol. 360, Issue 6390, pp. 739-742  doi: 10.1126/science.aap7999

http://science.sciencemag.org/content/360/6390/739

FonT

Per nostra - di noi umani - fortuna oggi si puo' analizzare, studiare ed eventualmente manipolare in modo fine il codice genetico di virus, batteri, etc. grazie alla tecnica CRISPR, tecnica a suo tempo (e per molto tempo) considerata di nessuna importanza da entita' di alta- altissima luminescenza ...

Eric S. Lander. The Heroes of CRISPR.
Cell. 14 January 2016, Vol.164(1): 18–28, doi:10.1016/j.cell.2015.12.041

http://www.sciencedirect.com/science/article/pii/S0092867415017055

Also: "CRISPR"

https://flashontrack.blogspot.com/search?q=crispr

https://www.ncbi.nlm.nih.gov/m/pubmed/?term=crispr

venerdì 18 agosto 2023

# gst: emergence of self-organizing zigzag patterns among (magnetic) particles suspended in a liquid


<< When molecules or bacteria organize into a long-range pattern, researchers want to understand how the microscopic interactions lead to the macroscopic order. (AA) observed such self-organization in magnetic particles suspended in a liquid and subjected to an oscillating magnetic field. Through experiments and simulations, the team showed that the resulting zigzag pattern is explained by the fluid flow generated around the oscillating particles, not by any details of the particles or the applied field. Similar zigzag patterns have also been seen in charged colloids subjected to oscillating electric fields, so the explanation may cover a range of particle systems. The researchers also believe that understanding and controlling the effect could lead to useful applications in microfluidics devices. >>️

David Ehrenstein. Self-Organized Zigzags from Fluid Flow. Physics 16, 138. Aug 11, 2023.

Gaspard Junot, Marco De Corato, Pietro Tierno. Large Scale Zigzag Pattern Emerging from Circulating Active Shakers. Phys. Rev. Lett. 131, 068301. Aug 11, 2023. 

Also: particle, self-assembly, chiral, behav, in: https://www.inkgmr.net/kwrds.html  

Keywords: gst, behavior, particle, self-assembly, self-organization, chiral, active shakers, squirmers, alternating chirality


giovedì 25 ottobre 2018

# tech: it repels everything with some beneficial exceptions

<< Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions. >>

Researchers design "smart" surfaces to repel everything but targeted beneficial exceptions. McMaster University. Oct 24, 2018

https://phys.org/news/2018-10-smart-surfaces-repel-beneficial-exceptions.html

Tohid Didar. Researchers design "smart" surfaces, creating promise for safer implants and more accurate diagnostic tests. Oct 24, 2018.

https://www.eng.mcmaster.ca/news/researchers-design-smart-surfaces-creating-promise-safer-implants-and-more-accurate-diagnostic

venerdì 7 gennaio 2022

# evol: viruses as a facilitator / driver of horizontal gene transfer among eukaryotes


<< Gene exchange between viruses and their hosts acts as a key facilitator of horizontal gene transfer and is hypothesized to be a major driver of evolutionary change. Our understanding of this process comes primarily from bacteria and phage co-evolution, but the mode and functional importance of gene transfers between eukaryotes and their viruses remain anecdotal. >>

AA << systematically characterized viral–eukaryotic gene exchange across eukaryotic and viral diversity, identifying thousands of transfers and revealing their frequency, taxonomic distribution and projected functions. Eukaryote-derived viral genes, abundant in the Nucleocytoviricota, highlighted common strategies for viral host-manipulation, including metabolic reprogramming, proteolytic degradation and extracellular modification. Furthermore, viral-derived eukaryotic genes implicate genetic exchange in the early evolution and diversification of eukaryotes, particularly through viral-derived glycosyltransferases, which have impacted structures as diverse as algal cell walls, trypanosome mitochondria and animal tissues. These findings illuminate the nature of viral–eukaryotic gene exchange and its impact on the evolution of viruses and their eukaryotic hosts. >>️

Irwin, N.A.T., Pittis, A.A., Richards, T.A. et al. Systematic evaluation of horizontal gene transfer between eukaryotes and viruses. Nat Microbiol. doi: 10.1038/ s41564-021-01026-3. Dec 31, 2021. 


<< We knew from individual examples that viral genes have played a role in the evolution of eukaryotes. Even humans have viral genes, which are important for our development and brain function, (..)  We wanted to understand more broadly how HGT (horizontal gene transfer) has affected viruses and eukaryotes from across the tree of life. >> Nicholas Irwin. ️

<< We were interested to find that certain groups of viruses, especially those that infect single-celled eukaryotes, acquire a lot of genes from their hosts, (..)  By studying the function of these genes we were able to make predictions about how these viruses affect their hosts during infection. >> Patrick Keeling.

<< Many of these viral-derived genes appear to have repeatedly affected the structure and form of different organisms, from the cell walls of algae to the tissues of animals, (..) This suggests that host-virus interactions may have played an important role in driving the diversity of life we see today. >> Nicholas Irwin. ️

<< These transfers not only have evolutionary consequences for both virus and host, but could have important health implications, >> Patrick Keeling.️

<< we think that this work serves as an interesting reminder that viruses have also contributed to the evolution of life on Earth, >>️ Nicholas Irwin. 
New research shows gene exchange between viruses and hosts drives evolution. University of British Columbia. Jan 5, 2022.


Also

Nonlinear effects in shaping human evolution, the role of viruses. Jan 15, 2019. 


keyword 'evolution'  in FonT


keyword 'evolution' | 'evoluzione'  in Notes (quasi-stochastic poetry)



Keywords: evolution, virus, gene exchange, horizontal gene transfer, HGT