# gst: intrinsic disorder bars intruders (from biomolecular condensates)

<< It was recently discovered that eukaryotic cells are host to a multiplicity of biomolecular condensates. These condensates typically contain protein and/or RNA components with intrinsically disordered regions (IDRs). While IDRs have been proposed and demonstrated to play many roles in condensate biology, (AA) suggest here an additional crucial role of IDRs, which is to exclude unwanted “intruders” from condensates. This exclusion effect arises from the large conformational entropy of IDRs; i.e., there is a high free-energy cost to occupying space that would otherwise be available to the IDRs. By combining polymer theory with sticker-spacer simulations, (They) show that the relevant insertion free energy increases with the concentration of IDRs in the condensate as well as with intruder size, attaining a linear scaling with surface area for large intruders. >>

AA << find that at realistic IDR concentrations, particles as small as the size of an average protein (4 nm in diameter) can be 97% excluded from condensates. To overcome this entropic barrier, molecules must interact favorably with condensate components to be recruited as clients. Application of the developed size-exclusion theory to biological condensates suggests that condensate IDRs may play a generic exclusionary role across organisms and types of condensates. >>️

Vladimir Grigorev, Ned S. Wingreen, Yaojun Zhang. Conformational Entropy of Intrinsically Disordered Proteins Bars Intruders from Biomolecular Condensates. PRX Life 3, 013011. Feb 14, 2025.

https://journals.aps.org/prxlife/abstract/10.1103/PRXLife.3.013011

Also: order, disorder, disorder & fluctuations, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, order, disorder, disorder & fluctuations, transitions

# life: oops! It would appear that Mr. Donald intends to open hunt for Academics as well ... maybe these people are penniless immigrants too?

<< A prominent US scientific society altered its website to remove references to diversity and equity ― terms targeted by the administration of US President Donald Trump. Articles about scientists who are members of under-represented groups also temporarily vanished from the site, although they have since reappeared. >>

<< In an e-mail, ASM (Am Soc for Microbiol) president Theresa Koehler told Nature that the organization had followed legal advice to review all of its webpages, in the hope of protecting its federally funded programmes. >>️

Humberto Basilio. ‘We are a target’: scientific society under pressure after Trump DEI crackdown. Nature. doi: 10.1038/ d41586-025-00372-0. Feb 7, 2025. 

https://www.nature.com/articles/d41586-025-00372-0

Also: A new exception within the FDA Cures Act Informed Consent, the intriguing concept of 'Minimal Risk Clinical Investigations'. FonT. Feb 1, 2024. 

https://flashontrack.blogspot.com/2024/02/life-new-exception-within-fda-cures-act.html 

Also: ️<< You should never be comfortable, man. Being comfortable fouled up a lot of musicians. >> Miles Davis. https://www.azquotes.com/quote/527910 

https://x.com/SVG__Collection/status/1886745080066695455

Also: oops, Mr. Donald, forms of power, virus, sars* covid* (aka 1or2achoos), dance, are you ready for all this, in https://www.inkgmr.net/kwrds.html 

Keywords: life, oops, Mr. Donald, forms of power, acad, virus, sars, covid, 1or2achoos, dance, are you ready for all this

# gst: rise and fall of a multicomponent droplet in a surrounding fluid along a bumpy path.

<< The coupling between mass transfer and hydrodynamic phenomena in two-phase flow is not straightforward due to the different effects that can be encountered. >>

Here, AA << consider the case of a two-component droplet (one miscible and one immiscible in water) released in a 2D rectangular domain filled with water. Mass transfer occurs between the miscible element and the surrounding water, which leads to a density inversion that directly affects the droplet trajectory through buoyancy. >>

Mirantsoa Aime Rasolofomanana, Romain Le Tellier, Herve Henry. Rise and fall of a multicomponent droplet in a surrounding fluid: Simulation study of a bumpy path. Phys. Rev. Fluids 10, 023601. Feb 5, 2025. 

https://journals.aps.org/prfluids/abstract/10.1103/PhysRevFluids.10.023601 

<< the coupling between the flow and the diffusion leads to a significant increase in the magnitude of the upward motion of the droplet before it starts to fall. >>️

arXiv: 2403.20040v2 [physics.flu-dyn]. Dec 18, 2024. 

https://arxiv.org/abs/2403.20040

Also: drop, droplet, droploid, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, drop, droplet, droploid 

# gst: necklacelike pattern of vortex bound states

<< A vortex is a topological defect in the superconducting condensate when a magnetic field is applied to a type-II superconductor, (..). Because of the confinement of the quasiparticles by a vortex, it exhibits a circular-shaped pattern of bound states with discrete energy levels, (..) >>

 Here, AA << report a completely new type of vortex pattern which is necklacelike in an iron-based superconductor (..). (AA) theoretical analysis shows that this necklacelike vortex pattern arises primarily from selective off-shell interference between vortex bound states of opposite angular momenta in the presence of rotational symmetry breaking due to disorders. >>

<< This fascinating effect can be observed in a system with a small Fermi energy and wave vector, conditions fortuitously met in (Their) samples. (AA) results not only disclose a novel vortex structure, but also unravel a completely new quantum phenomenon in the superconducting condensate. >>️

Zhiyong Hou, Kailun Chen, et al. Necklacelike Pattern of Vortex Bound States. Phys. Rev. X 15, 011027. Feb 7, 2025.   https://journals.aps.org/prx/abstract/10.1103/PhysRevX.15.011027   arXiv: 2407.08547v1 [cond-mat.supr-con]. Jul 11, 2024.    https://arxiv.org/abs/2407.08547

Also: vortex, disorder, disorder & fluctuations, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, vortex, vortex bound states, symmetry breaking, disorder, disorder & fluctuations, necklacelike patterns

# gst: chaotic billiards inside mixed curvatures

<< The boundary of a billiard system dictates its dynamics, which can be integrable, mixed, or fully chaotic. >>️

This AA study << introduces two such billiards: a bean-shaped billiard and a peanut-shaped billiard, the latter being a variant of Cassini ovals. Unlike traditional chaotic billiards, these systems incorporate both focusing and defocusing regions along their boundaries, with no neutral segments. >>

AA << examine both classical and quantum dynamics of these billiards and observe a strong alignment between the two perspectives. For classical analysis, the billiard flow diagram and billiard map reveal sensitivity to initial conditions, a hallmark of classical chaos. In the quantum domain, (AA) use nearest-neighbour spacing distribution and spectral complexity as statistical measures to characterise chaotic behaviour. >>

<< Both classical and quantum mechanical analysis are in firm agreement with each other. One of the most striking quantum phenomena (They) observe is the eigenfunction scarring (both scars and super-scars). Scarring phenomena serve as a rich visual manifestation of quantum and classical correspondence, and highlight quantum suppression chaos at a local level. >>

Pranaya Pratik Das, Tanmayee Patra, Biplab Ganguli. Manifestations of chaos in billiards: the role of mixed curvature. arXiv: 2501.08839v1 [nlin.CD]. Jan 15, 2025.

https://arxiv.org/abs/2501.08839

Also: billiard, chaos, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, billiard, chaos

# gst: apropos of subdiffusive behaviors, the boomerang effect in classical stochastic models.

<< The phenomenon of Anderson localization, occurring in a disordered medium, significantly influences the dynamics of quantum particles. A fascinating manifestation of this is the “quantum boomerang effect” (QBE), observed when a quantum particle, propelled with a finite initial velocity, reverses its average trajectory, eventually halting at its starting point. >>

AA << uncover evidence of a similar effect in classical systems, characterized by the absence of typical diffusion processes. (Their) investigation encompasses both simplified probabilistic models and more complex phenomenological models that link classical with quantum mechanics. The results indicate that the boomerang effect is not confined to the quantum realm and may also be present in diverse systems exhibiting subdiffusive behavior. >>️

Santiago Zamora, Lisan M. M. Durao, et al. Boomerang effect in classical stochastic models. Phys. Rev. E 111, 024104. Feb 3, 2025.

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.111.024104 

Also: behav, particle, disorder, disorder & fluctuations, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, behavior, particles, disorder, disorder & fluctuations, stocasticity, boomerang effect

# life: apropos of singular bizarre synchronies and extreme syntheses

(●) Black Sabbath, Ozzy Osbourne, et al. Back to the Beginning. Birmingham Villa Park. Saturday Doors: 12:00

https://www.livenation.co.uk/back-to-the-beginning-tickets-adp1561055

(●) << Learn 2 chords and then get a good lawyer before learning the 3rd. >>. Tony Iommi

https://www.azquotes.com/quote/1522713 

Also: Ozzy, in FonT https://flashontrack.blogspot.com/search?q=ozzy

Also: music, jazz, dance, three balls, in https://www.inkgmr.net/kwrds.html 

Keywords: life, music, jazz, dance, three balls, Ozzy