<< A new “bursty growth” model for organelles—internal components of biological cells—helps explain observed size fluctuations. >>
<< Biologists have identified within cells many specialized structures called organelles that carry out crucial tasks, but how cells regulate the size and the number of organelles has remained a puzzle. Now, using simulations backed by experiments, biophysicists have demonstrated that cells appear to produce organelles through a seemingly erratic, or “bursty,” growth process, which enables them to control average organelle sizes and numbers while also constraining organelle size variations within any cell. The work helps to build up a more fundamental understanding of the mechanisms of cellular function. >>️
<< We wondered if organelle growth, far from being an orderly ‘brick-by-brick’ assembly, might occur in more random bursts, (..) The burst model can thus explain how cells balance organelle sizes and numbers while also keeping size fluctuations within a narrow window, >> Shankar Mukherji.
<< This “universal” behavior suggests that the burst mechanism underlies all organelle growth, despite the fact that each organelle has a unique building process. >>️
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Mark Buchanan. Organelle Building Codes. Physics 16, 3. Jan 6, 2023.
Kiandokht Panjtan Amiri, Asa Kalish, Shankar Mukherji. Robustness and Universality in Organelle Size Control. Phys. Rev. Lett. 130, 018401. Jan 6, 2023.
Also
keyword 'growth' in FonT
keyword 'erratico' | 'erratica' in Notes
(quasi-stochastic poetry)
keyword 'erratic' in FonT
Keywords: gst, cell, cell assembly, growth, erratic growth, transition
