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Visualizzazione dei post in ordine di pertinenza per la query chaos. Ordina per data Mostra tutti i post
Visualizzazione dei post in ordine di pertinenza per la query chaos. Ordina per data Mostra tutti i post

venerdì 10 febbraio 2023

# gst: apropos of transitions, a perpetual dance between states of meta-stability and chaos (in brain).


<< Hello! Today: new research is shining a light on how our brains flit between states of stability and chaos, depending on what we’re doing. >>

<< Our brains exist in a state somewhere between stability and chaos as they help us make sense of the world, according to recordings of brain activity taken from volunteers over the course of a week. >>

<< As we go from reading a book to chatting with a friend, for example, our brains shift from one semi-stable state to another—but only after chaotically zipping through multiple other states in a pattern that looks completely random. >>

<< Understanding how our brains restore some degree of stability after chaos could help us work out how to treat disorders at either end of this spectrum. Too much chaos is probably what happens when a person has a seizure, whereas too much stability might leave a person comatose. >>

Jessica Hamzelou. Neuroscientists listened in on people’s brains for a week. They found order and chaos. Rhiannon Williams. MIT Download. Feb 8, 2023.


<< The team (Avniel Ghuman, Maxwell Wang, et al.) found some surprising patterns in brain activity over the course of the week. Specific brain networks seemed to communicate with each other in what looked like a “dance,” with one region appearing to “listen” while the other “spoke,” say the researchers, who presented their findings at the Society for Neuroscience annual meeting in San Diego last year. >>

Jessica Hamzelou. MIT Tech Rev. Feb 7, 2023. 

Also 

keyword 'danza' in Notes
(quasi-stochastic poetry)

keyword 'dance' in FonT

keyword 'cervello' | 'brain' in Notes
(quasi-stochastic poetry)


keyword 'brain' in FonT

keyword 'chaos' | 'chaotic' in Font


keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)


<< Amico, qualunque  cosa suonerai . . . >>  Jelly Roll Morton. cit.: 2113 - soniche a ramulo. Jan 28, 2007


Keywords: gst, brain, transition, chaos, dance



venerdì 22 novembre 2024

# gst: protected chaos in a topological lattice.

<< The erratic nature of chaotic behavior is thought to erode the stability of periodic behavior, including topological oscillations. However, (AA) discover that in the presence of chaos, non-trivial topology not only endures but also provides robust protection to chaotic dynamics within a topological lattice hosting non-linear oscillators. >>

<< Despite the difficulty in defining topological invariants in non-linear settings, non-trivial topological robustness still persists in the parametric state of chaotic boundary oscillations. (AA) demonstrate this interplay between chaos and topology by incorporating chaotic Chua's circuits into a topological Su-Schrieffer-Heeger (SSH) circuit. >>

<< By extrapolating from the linear limit to deep into the non-linear regime, (AA) find that distinctive correlations in the bulk and edge scroll dynamics effectively capture the topological origin of the protected chaos. (Their)  findings suggest that topologically protected chaos can be robustly achieved across a broad spectrum of periodically-driven systems, thereby offering new avenues for the design of resilient and adaptable non-linear networks. >>️

Haydar Sahin, Hakan Akgün, et al. Protected chaos in a topological lattice. arXiv: 2411.07522v1 [cond-mat.mes-hall]. Nov 12, 2024.

Also: chaos, random, instability, transition, network, ai (artificial intell), in https://www.inkgmr.net/kwrds.html 

Keywords: gst, chaos, random,  instability, transition, network, AI, Artificial Intelligence


mercoledì 19 maggio 2021

# gst: a scenario in which System Theory meets Poetry, bird's-eye vistas into a primitive chaos

<< The notion of primitive chaos was proposed [J. Phys. Soc. Jpn. 79, 15002 (2010)] as a notion closely related to the fundamental problems of physics itself such as determinism, causality, free will, predictability, and irreversibility. In this letter, (AA) introduce the notion of bird's-eye view into the primitive chaos, and (they) find a new hierarchic structure of the primitive chaos. This means that if we find a chaos in a real phenomenon or a computer simulation, behind it, we can clearly realize the possibility of tremendous varieties of chaos in the hierarchic structure unless we can see them visually. >>

<< This fact provides a totally new method of viewing our world. >>️️

Yoshihito Ogasawara. Bird's-Eye View of Primitive Chaos. arXiv:2105.04796v2 [nlin.CD]. May 17, 2021. 


Also

Ludwig von Bertalanffy  (gst)  


keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)




martedì 9 luglio 2024

# gst: discontinuous transition to chaos in a canonical random neural network


AA << study a paradigmatic random recurrent neural network introduced by Sompolinsky, Crisanti, and Sommers (SCS). In the infinite size limit, this system exhibits a direct transition from a homogeneous rest state to chaotic behavior, with the Lyapunov exponent gradually increasing from zero. (AA)  generalize the SCS model considering odd saturating nonlinear transfer functions, beyond the usual choice 𝜙⁡(𝑥)=tanh⁡𝑥. A discontinuous transition to chaos occurs whenever the slope of 𝜙 at 0 is a local minimum [i.e., for 𝜙′′′⁢(0)>0]. Chaos appears out of the blue, by an attractor-repeller fold. Accordingly, the Lyapunov exponent stays away from zero at the birth of chaos. >>

In the figure 7 << the pink square is located at the doubly degenerate point (𝑔,𝜀)=(1,1/3). >>️️

Diego Pazó. Discontinuous transition to chaos in a canonical random neural network. Phys. Rev. E 110, 014201. July 1, 2024.

Also: chaos, random, network, transition, neuro, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, chaos, random, network, transition, neuro


venerdì 26 luglio 2024

# gst: Resonancelike emergence of chaos in complex networks of damped-driven nonlinear systems.

AA << solve a critical outstanding problem in this multidisciplinary research field: the emergence and persistence of spatiotemporal chaos in complex networks of damped-driven nonlinear oscillators in the significant weak-coupling regime, while they exhibit regular behavior when uncoupled. >>

They << uncover and characterize the basic physical mechanisms concerning both heterogeneity-induced and impulse-induced emergence, enhancement, and suppression of chaos in starlike and scale-free networks of periodically driven, dissipative nonlinear oscillators. >>️

Ricardo Chacon, Pedro J. Martínez. Resonancelike emergence of chaos in complex networks of damped-driven nonlinear systems. Phys. Rev. E 110, 014209. Jul 19, 2024. 

Also: network, chaos, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, network, resonance, chaos


venerdì 12 luglio 2024

# gst: apropos of the transition of order from chaos, a universal behavior near a critical point.

<< As the Reynolds number is increased, a laminar fluid flow becomes turbulent, and the range of time and length scales associated with the flow increases. Yet, in a turbulent reactive flow system, as we increase the Reynolds number, (AA) observe the emergence of a single dominant timescale in the acoustic pressure fluctuations, as indicated by its loss of multifractality. >>️

AA << study the evolution of short-time correlated dynamics between the acoustic field and the flame in the spatiotemporal domain of the system.   >>️

<< the susceptibility of the order parameter, correlation length, and correlation time diverge at a critical point between chaos and order. (AA) results show that the observed emergence of order from chaos is a continuous phase transition (..) the critical exponents characterizing this transition fall in the universality class of directed percolation. >>️

The << paper demonstrates how a real-world complex, nonequilibrium turbulent reactive flow system exhibits universal behavior near a critical point. >>️

Sivakumar Sudarsanan, Amitesh Roy, et al. Emergence of order from chaos through a continuous phase transition in a turbulent reactive flow system. Phys. Rev. E 109, 064214. Jun 20, 2024. 

Also: order, chaos, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, order, chaos, transition 


mercoledì 3 marzo 2021

# gst: labyrinth chaos: revisiting the elegant, chaotic and hyperchaotic walks

<< Labyrinth chaos was discovered by Otto Rossler and Rene' Thomas in their endeavour to identify the necessary mathematical conditions for the appearance of chaotic and hyperchaotic motion in continuous flows. Here, (AA) celebrate their discovery by considering a single labyrinth walks system and an array of coupled labyrinth chaos systems that exhibit complex, chaotic behaviour, reminiscent of chimera-like states, a peculiar synchronisation phenomenon. >>

 << As all Rossler’s pioneering contributions, labyrinth chaos still holds promise for very interesting further developments. Its simplicity and elegance, both in terms of symmetries, topology and feedback-circuit structure, makes it a good candidate to compare it with other nonlinear, cyclically coupled systems, such as the Arabesques, the Lotka-Voltera system and its variants, and the Arnold-Beltrami-Childress  model. >> 

Vasileios Basios, Chris G. Antonopoulos, Anouchah Latifi. Labyrinth chaos: Revisiting the elegant, chaotic and hyperchaotic walks. arXiv: 2011.11009v1. Nov 22, 2020.






sabato 16 novembre 2024

# gst: apropos of transverse instabilities, from chimeras to extensive chaos

<< Populations of coupled oscillators can exhibit a wide range of complex dynamical behavior, from complete synchronization to chimera and chaotic states. We can thus expect complex dynamics to arise in networks of such populations. >>️

Here AA << analyze the dynamics of networks of populations of heterogeneous mean-field coupled Kuramoto-Sakaguchi oscillators, and show that the instability that leads to chimera states in a simple two-population model also leads to extensive chaos in large networks of coupled populations. >>️

Pol Floriach, Jordi Garcia-Ojalvo, Pau Clusella. From chimeras to extensive chaos in networks of heterogeneous Kuramoto oscillator populations. arXiv: 2407.20408v2 [nlin.CD]. Oct 11, 2024.

Also: chimera, instability, chaos, network, in 

Keywords: gst, chimera, instability, chaos, network


giovedì 1 agosto 2024

# game: hypothesis of a geometric design of chaotic attractors, on demand


AA << propose a method using reservoir computing to generate chaos with a desired shape by providing a periodic orbit as a template, called a skeleton. (They) exploit a bifurcation of the reservoir to intentionally induce unsuccessful training of the skeleton, revealing inherent chaos. The emergence of this untrained attractor, resulting from the interaction between the skeleton and the reservoir's intrinsic dynamics, offers a novel semi-supervised framework for designing chaos. >>️

Tempei Kabayama, Yasuo Kuniyoshi, et al. Designing Chaotic Attractors: A Semi-supervised Approach. arXiv: 2407.09545v1 [cs.NE]. Jun 27, 2024.

Also: game, chaos in https://www.inkgmr.net/kwrds.html 

Keywords: game, chaos, chaotic attractors


lunedì 10 giugno 2024

# gst: chaos controlled and disorder driven phase transitions by breaking permutation symmetry


<< Introducing disorder in a system typically breaks symmetries and can introduce dramatic changes in its properties such as localization. At the same time, the clean system can have distinct many-body features depending on how chaotic it is. >>

<< In this work the effect of permutation symmetry breaking by disorder is studied in a system which has a controllable and deterministic regular to chaotic transition. >>

<< Results indicate a continuous phase transition from an area-law to a volume-law entangled phase irrespective of whether there is chaos or not, as the strength of the disorder is increased. The critical disorder strength obtained by finite size scaling, indicate a strong dependence on whether the clean system is regular or chaotic to begin with. >>

<< Additionally, (AA) find that a relatively small disorder is seen to be sufficient to delocalize a chaotic system. >>

Manju C, Arul Lakshminarayan, Uma Divakaran. Chaos controlled and disorder driven phase transitions by breaking permutation symmetry. arXiv: 2406.00521v1 [quant-ph]. Jun 1, 2024. 

Also: transition, chaos, disorder, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, transition, chaos, disorder 

FonT: who is Manju C?



venerdì 30 marzo 2018

# gst: quantum chaos to approach the evolution of a dynamic system

<< A study on the evolution of dynamic systems [..] has unexpectedly led to a better understanding of the chaos in the quantum world >>

<< The tools needed to explore the rigidity of dynamic systems [..] far exceeded those currently available, forcing the team to learn from neighboring disciplines >>

<< As a by-product of this process, researchers have identified the applicability of this project to quantum mechanics, which has led them to formulate a new theorem of thermodynamic quantum chaos combining ideas from large networks. Large networks — such as Big Data, social networks, convolutional neural networks of Artificial Intelligence models — which, although commonly used today, do not yet have adequate theories to explain their operation >>

Shakes Gilles. Study of dynamical systems leads to better understanding of quantum chaos. March 27, 2018.

https://www.thetalkingdemocrat.com/2018/03/study-of-dynamical-systems-leads-to-better-understanding-of-quantum-chaos/

mercoledì 30 giugno 2021

# gst: weird Nature; randomly arranged nanowire networks seem to behave, at the edge of chaos, like cortical neuronal cultures

<< an artificial network of nanowires can be tuned to respond in a brain-like way when electrically stimulated. >>️

<< If the signal stimulating the network was too low, then the pathways were too predictable and orderly and did not produce complex enough outputs to be useful. If the electrical signal overwhelmed the network, the output was completely chaotic and useless for problem solving. The optimal signal for producing a useful output was at the edge of this chaotic state. >>️

<< Some theories in neuroscience suggest the human mind could operate at this edge of chaos, or what is called the critical state, (..) Some neuroscientists think it is in this state where we achieve maximal brain performance. (..) What's so exciting about this result is that it suggests that these types of nanowire networks can be tuned into regimes with diverse, brain-like collective dynamics, which can be leveraged to optimize information processing. >> Zdenka Kuncic.️

<< In the nanowire network the junctions between the wires allow the system to incorporate memory and operations into a single system. This is unlike standard computers, which separate memory (RAM) and operations (CPUs). >>

<< These junctions act like computer transistors but with the additional property of remembering that signals have traveled that pathway before. As such, they are called 'memristors', >> Joel Hochstetter.
'Edge of chaos' opens pathway to artificial intelligence discoveries. University of Sydney. Jun 29, 2021.


Joel Hochstetter, Ruomin Zhu, et al. Avalanches and edge-of-chaos learning in neuromorphic nanowire networks. Nat Commun 12, 4008. doi: 10.1038/ s41467-021-24260-z. Jun 29, 2021.





martedì 5 aprile 2022

# gst: the solitary route to chimera states.

AA << show how solitary states in a system of globally coupled FitzHugh-Nagumo oscillators can lead to the emergence of chimera states. By a numerical bifurcation analysis of a suitable reduced system in the thermodynamic limit (they) demonstrate how solitary states, after emerging from the synchronous state, become chaotic in a period-doubling cascade. Subsequently, states with a single chaotic oscillator give rise to states with an increasing number of incoherent chaotic oscillators. In large systems, these chimera states show extensive chaos. (AA) demonstrate the coexistence of many of such chaotic attractors with different Lyapunov dimensions, due to different numbers of incoherent oscillators. >>

<<  While it is well known that self-organized wave patterns typically coexist within an interval of possible different wave numbers (..)(AA) show here the coexistence of coherence-incoherence patterns with different numbers of incoherent oscillators, which are in fact coexisting chaotic attractors with different Lyapunov dimensions. The incoherent oscillators in these coexisting attractors show extensive chaos of different dimensions. The total share of incoherent oscillators in a chimera state is a macroscopic quantity. Hence, within the range of such shares, where stable chimera states exist, (AA) find, for large systems, an increasing number of coexisting attractors with their numbers of incoherent oscillators increasing as well. (They) showed that, varying the coupling parameter, this extensive scenario is linked to the thermodynamic limit of the solitary regime, where the range of admissible numbers of incoherent oscillators shrinks down to one single oscillator in an infinitely large system. For this case, the emergence of the chaotic motion of the single incoherent oscillator could be shown in a period doubling cascade. >>

Leonhard Schulen, Alexander Gerdes, et al. The solitary route to chimera states. arXiv:2204.00385v1 [nlin.CD]. Apr 1, 2022.


Also

keyword 'FitzHugh-Nagumo oscillators' in APS | PubMed



keyword 'chaos' | 'chaotic' in Font



keyword 'caos' | 'caotico' in Notes (quasi-stochastic poetry)



keywords: gst, solitons, solitary states, period-doubling cascade, chaos, Lyapunov dimension, FitzHugh-Nagumo oscillator, chimera state, dynamical systems.







sabato 29 marzo 2025

# gst: apropos of multiple delays, transitions to intermittent chaos in quorum sensing-inspired dynamics.

<< This study analyses the dynamical consequences of heterogeneous temporal delays within a quorum sensing-inspired (QS-inspired) system, specifically addressing the differential response kinetics of two subpopulations to signalling molecules. >>️

<< The analysis reveals the critical role of multiple, dissimilar delays in modulating system dynamics and inducing bifurcations. Numerical simulations, conducted in conjunction with analytical results, reveal the emergence of periodic self-sustained oscillations and intermittent chaotic behaviour. These observations emphasise the intricate relationship between temporal heterogeneity and the stability landscape of systems exhibiting QS-inspired dynamics. This interplay highlights the capacity for temporal variations to induce complex dynamical transitions within such systems. >>️

AA << findings show that the presence of multiple delays, particularly when characterised by significant disparities in magnitude, can dramatically alter the system’s stability features and promote the emergence of complex nonlinear oscillatory behaviour. >>️

<< Upon explicitly incorporating distinct delays for different state-components, (AA) have shown how temporal factors can dramatically influence system stability and give rise to a spectrum of complex dynamical behaviours, including intermittent chaos. >>

Anahí Flores, Marcos A. González, Víctor F. Breña-Medina. Transitions to Intermittent Chaos in Quorum Sensing Dynamics. arXiv: 2503.14363v2 [nlin.CD]. Mar 19, 2025.

Also: intermittency, pause, silence, transitionchaos, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, intermittency, pause, silence, transitions, chaos 

martedì 24 ottobre 2017

# gst: it would use chaos to compute efficiently

<< When you’re really harried, you probably feel like your head is brimful of chaos. You’re pretty close. Neuroscientists say your brain operates in a regime termed the “edge of chaos,” and it’s actually a good thing. It’s a state that allows for fast, efficient analog computation of the kind that can solve problems that grow vastly more difficult as they become bigger in size >>

<< A micrograph shows the construction of a Mott memristor composed of an 8-nanometer-thick layer of niobium dioxide between two layers of titanium nitride >>

Samuel K. Moore. Memristor-Driven Analog Compute Engine Would Use Chaos to Compute Efficiently. Oct  9, 2017

https://spectrum.ieee.org/nanoclast/semiconductors/devices/memristordriven-analog-compute-engine-would-use-chaos-to-compute-efficiently

FonT

"When you’re really harried" ... only?

mercoledì 12 febbraio 2025

# gst: chaotic billiards inside mixed curvatures


<< The boundary of a billiard system dictates its dynamics, which can be integrable, mixed, or fully chaotic. >>️

This AA study << introduces two such billiards: a bean-shaped billiard and a peanut-shaped billiard, the latter being a variant of Cassini ovals. Unlike traditional chaotic billiards, these systems incorporate both focusing and defocusing regions along their boundaries, with no neutral segments. >>

AA << examine both classical and quantum dynamics of these billiards and observe a strong alignment between the two perspectives. For classical analysis, the billiard flow diagram and billiard map reveal sensitivity to initial conditions, a hallmark of classical chaos. In the quantum domain, (AA) use nearest-neighbour spacing distribution and spectral complexity as statistical measures to characterise chaotic behaviour. >>

<< Both classical and quantum mechanical analysis are in firm agreement with each other. One of the most striking quantum phenomena (They) observe is the eigenfunction scarring (both scars and super-scars). Scarring phenomena serve as a rich visual manifestation of quantum and classical correspondence, and highlight quantum suppression chaos at a local level. >>

Pranaya Pratik Das, Tanmayee Patra, Biplab Ganguli. Manifestations of chaos in billiards: the role of mixed curvature. arXiv: 2501.08839v1 [nlin.CD]. Jan 15, 2025.

Also: billiard, chaos, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, billiard, chaos


martedì 1 aprile 2025

# epidem: societal self-regulation appears to induce complex infection dynamics and chaos.


<< Classically, endemic infectious diseases are expected to display relatively stable, predictable infection dynamics. Accordingly, basic disease models such as the susceptible-infected-recovered-susceptible model display stable endemic states or recurrent seasonal waves. However, if the human population reacts to high infection numbers by mitigating the spread of the disease, then this delayed behavioral feedback loop can generate infection waves itself, driven by periodic mitigation and subsequent relaxation. >>

AA << show that such behavioral reactions, together with a seasonal effect of comparable impact, can cause complex and unpredictable infection dynamics, including Arnold tongues, coexisting attractors, and chaos. >>

<< Importantly, these arise in epidemiologically relevant parameter regions where the costs associated to infections and mitigation are jointly minimized. By comparing (Their) model to data, (AA) find signs that COVID-19 was mitigated in a way that favored complex infection dynamics. (AA)  results challenge the intuition that endemic disease dynamics necessarily implies predictability and seasonal waves and show the emergence of complex infection dynamics when humans optimize their reaction to increasing infection numbers. >>️

Joel Wagner, Simon Bauer, et al.  Societal self-regulation induces complex infection dynamics and chaos. Phys. Rev. Research 7, 013308. Mar 24, 2025.

Also: virus, sars* covid* (aka 1or2achoos), waves, chaos, in https://www.inkgmr.net/kwrds.html 

Keywords: epidemiology, virus, sars, covid-19, chaos

lunedì 14 ottobre 2019

# gst: chaotic dynamics modulate complex systems, even in the presence of extrinsic and intrinsic noise

AA << find that chaotic dynamics modulates gene expression and up-regulates certain families of low-affinity genes, even in the presence of extrinsic and intrinsic noise. Furthermore, this leads to an increase in the production of protein complexes and the efficiency of their assembly. Finally, (AA) show how chaotic dynamics creates a heterogeneous population of cell states, and describe how this can be beneficial in multi-toxic environments. >>

Mathias L. Heltberg, Sandeep Krishna, Mogens H. Jensen. On chaotic dynamics in transcription factors and the associated effects in differential gene regulation.  Nature Comm. volume 10, Article number: 71 Jan 8, 2019.   https://www.nature.com/articles/s41467-018-07932-1  

<< Chaos in bodily regulation can optimize our immune system according to a recent discovery made by researchers at the University of Copenhagen's Niels Bohr Institute. The discovery may prove to be of great significance for avoiding serious diseases such as cancer and diabetes.  >>

Chaos in the body tunes up your immune system. Niels Bohr Institute.
Jan 16, 2019.   https://m.medicalxpress.com/news/2019-01-chaos-body-tunes-immune.html

Also

'l'immaginifico "tracciante ... che svagola nella macina ...'    in:  2149 - onda di predazione (to knock seals off the ice). Notes. Dec 17, 2007.    https://inkpi.blogspot.com/2007/12/2149-onda-di-predazione-to-knock-seals.html

Also

never boring with chaos and tit-for-tat theories. F.on.T. Jun 12, 2016.  https://flashontrack.blogspot.com/2016/06/s-gst-never-boring-with-chaos-and-tit.html

lunedì 3 febbraio 2025

# gst: limit cycles and chaos in planar hybrid systems.

<< The main inspiration of (this AA) work is the paper of Llibre and Teixeira (Nonlinear Dyn. 91, No. 1, 249-255, 2018) about Filippov systems formed by two linear centers and having x = 0 as discontinuity line. One of the main conclusions of the paper is that such systems cannot have limit cycles. Actually, either it does not have periodic orbits or every orbit is periodic. Therefore, its dynamics is relatively simple. Inspired by this work and the raising notion of hybrid systems, (AA) wondered what could happen if we allow jumps on the discontinuity line. As a result, (They) discovered not only that limit cycles are allowed with arbitrarily small “perturbations” in the jump, (..), but also that such systems allow chaotic dynamics. Therefore, (AA) conclude that hybrid systems with simple formulation can have rich dynamics. (They) also observe that a complete characterization of the dynamics of X ∈ Xn depends on the characterization of its first return map, which is a piecewise polynomial map on the real line. This, together with the fact that the systems studied here are a generalization of the Filippov systems (..), illustrates that hybrid systems can be seen as a three-fold bridge connecting continuous, piecewise continuous and discrete dynamical systems. >>️

Jaume Llibre, Paulo Santana. Limit cycles and chaos in planar hybrid systems. arXiv: 2407.05151v2 [math.DS]. Oct 1, 2024. 

Also: chaos, transition, in https://www.inkgmr.net/kwrds.html 

Keywords: gst, limit cycles, chaos, transitions, small perturbations, jumps  


lunedì 3 settembre 2018

# gst: a chaos-inducing approach against superbugs evolution

<< The CHAOS [Controlled Hindrance of Adaptation of OrganismS] method takes advantage of this effect, pulling multiple genetic levers in order to build up stress on the bacterial cell and eventually trigger a cascading failure, leaving the bug more vulnerable to current treatments. The technique does not alter the bug's DNA itself, only the expression of individual genes, similar to the way a coded message is rendered useless without the proper decryption. >>

<< We now have a way to cut off the evolutionary pathways of some of the nastiest bugs and potentially prevent future bugs from emerging at all, >> Peter Otoupal

Chaos-inducing genetic approach stymies antibiotic-resistant superbugs. University of Colorado at Boulder. Sept 3, 2018.

https://m.phys.org/news/2018-09-chaos-inducing-genetic-approach-stymies-antibiotic-resistant.html 

<< While individual perturbations improved fitness during antibiotic exposure, multiplexed perturbations caused large fitness loss in a significant epistatic fashion. >>

Peter B. Otoupal, William T. Cordell, et al. Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis. Comm  Biol 1 (129) Sept 3, 2018

https://www.nature.com/articles/s42003-018-0135-2